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Official Full Name amine oxidase, copper containing 2 (retina-specific)
Background Copper amine oxidases catalyze the oxidative conversion of amines to aldehydes and ammonia in the presence of copper and quinone cofactor. This gene shows high sequence similarity to copper amine oxidases from various species ranging from bacteria to mammals. The protein contains several conserved motifs including the active site of amine oxidases and the histidine residues that likely bind copper. It may be a critical modulator of signal transmission in retina, possibly by degrading the biogenic amines dopamine, histamine, and putrescine. This gene may be a candidate gene for hereditary ocular diseases. Alternate splicing results in multiple transcript variants.
Synonyms AOC2; amine oxidase, copper containing 2 (retina-specific); retina-specific copper amine oxidase; DAO2; RAO; Amine oxidase [copper containing]; Amine oxidase copper containing 2 (retina specific); Amine oxidase copper containing 2; Retina specific copper amine oxidase; SSAO; semicarbazide-sensitive amine oxidase
    • Species :
    • Human
    • Mouse
    • Zebrafish
    • Source :
    • E.coli
    • HEK293
    • HEK293T
    • Mammalian Cell
    • Wheat Germ
    • Tag :
    • GST
    • His
    • Myc/DDK
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human AOC2-4669H Recombinant Human AOC2 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
    Human AOC2-640H Recombinant Human AOC2 protein, GST-tagged Wheat Germ GST
    Human AOC2-8822HCL Recombinant Human AOC2 293 Cell Lysate HEK293 N/A
    Human AOC2-8823HCL Recombinant Human AOC2 293 Cell Lysate HEK293 N/A
    Human AOC2-9704H Recombinant Human AOC2, His-tagged E.coli His
    Mouse Aoc2-1652M Recombinant Mouse Aoc2 Protein, Myc/DDK-tagged HEK293T Myc/DDK
    Mouse AOC2-1723M Recombinant Mouse AOC2 Protein Mammalian Cell His
    Zebrafish AOC2-2213Z Recombinant Zebrafish AOC2 Mammalian Cell His

    aoc2 involved in several pathways and played different roles in them. We selected most pathways aoc2 participated on our site, such as Glycine, serine and threonine metabolism, Tyrosine metabolism, Phenylalanine metabolism, which may be useful for your reference. Also, other proteins which involved in the same pathway with aoc2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Glycine, serine and threonine metabolism MAOA; SRR; AGXT2; PHGDH; CHDH; PSAT1; THA1; DAO; AGXTB; ALAS1
    Tyrosine metabolism AOX2P; TH; TPO; HPDB; MIF; FAH; COMTA; ALDH3B2; HGD; AOX3L1
    Phenylalanine metabolism MAOA; TAT; IL4I1; GM4952; ALDH3B2; GOT2B; MIF; HPDA; GOT2; HPDB
    beta-Alanine metabolism MLYCD; ALDH7A1; SRM; ALDH3A1; ALDH3A2; ALDH1A3; ALDH3B2; ALDH2; HADHAB; ALDH9A1B
    Metabolic pathways TGDS; CYP27B1; MGAT3A; GALCA; Acsm2a; PI4KB; CEPT1; CYP26B1; CERS5; EXT1A

    aoc2 has several biochemical functions, for example, aliphatic-amine oxidase activity, aminoacetone:oxygen oxidoreductase(deaminating) activity, copper ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by aoc2 itself. We selected most functions aoc2 had, and list some proteins which have the same functions with aoc2. You can find most of the proteins on our site.

    Function Related Protein
    aliphatic-amine oxidase activity AOC3; AOC2
    aminoacetone:oxygen oxidoreductase(deaminating) activity AOC3; AOC2
    copper ion binding CCC2; PAM; MT3; LOXL4; DBH; TP53; MT1; LOXL1; SOD1; AOC3
    electron carrier activity UGDH; CYCSB; AOX1; ASPH; ALDH4A1; PHGDH; MAOB; GLRX; AKR1A1; COX7A2A
    phenethylamine:oxygen oxidoreductase (deaminating) activity AOC3; AOC2
    primary amine oxidase activity VCAM1; AOC3; AOC2; MAOA; MAOB; ABP1; AOC1
    quinone binding ABP1; VKORC1L1; SQRDL; AMOTL1; VKORC1; NDUFS2; HHIPL1; TP53I3; AOC3; ETFDH
    tryptamine:oxygen oxidoreductase (deaminating) activity AOC2; AOC3

    aoc2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with aoc2 here. Most of them are supplied by our site. Hope this information will be useful for your research of aoc2.

    Imamura, Y; Kubota, R; et al. Human retina-specific amine oxidase (RAO): cDNA cloning, tissue expression, and chromosomal mapping. GENOMICS 40:277-283(1997).

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