AOC2
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Official Full Name
amine oxidase, copper containing 2 (retina-specific)
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Overview
Copper amine oxidases catalyze the oxidative conversion of amines to aldehydes and ammonia in the presence of copper and quinone cofactor. This gene shows high sequence similarity to copper amine oxidases from various species ranging from bacteria to mammals. The protein contains several conserved motifs including the active site of amine oxidases and the histidine residues that likely bind copper. It may be a critical modulator of signal transmission in retina, possibly by degrading the biogenic amines dopamine, histamine, and putrescine. This gene may be a candidate gene for hereditary ocular diseases. Alternate splicing results in multiple transcript variants. -
Synonyms
AOC2; amine oxidase, copper containing 2 (retina-specific); retina-specific copper amine oxidase; DAO2; RAO; Amine oxidase [copper containing]; Amine oxidase copper containing 2 (retina specific); Amine oxidase copper containing 2; Retina specific copper amine oxidase; SSAO; semicarbazide-sensitive amine oxidase;
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Human
- Mouse
- Zebrafish
- E.coli
- HEK293
- HEK293T
- In Vitro Cell Free System
- Mammalian Cell
- Mammalian cells
- Wheat Germ
- Flag
- GST
- His
- His (Fc)
- Avi
- Myc
- DDK
- N/A
- N
- Involved Pathway
- Protein Function
- Interacting Protein
- AOC2 Related Articles
AOC2 involved in several pathways and played different roles in them. We selected most pathways AOC2 participated on our site, such as Glycine, serine and threonine metabolism, Tyrosine metabolism, Phenylalanine metabolism, which may be useful for your reference. Also, other proteins which involved in the same pathway with AOC2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Glycine, serine and threonine metabolism | DAO.1;MAOA;AGXTA;GRHPRA;GAMT;DAO.3;PIPOX;AGXTB;GLDC |
| Tyrosine metabolism | TAT;HPDB;TYRP1;ADH2-2;AOX3L1;AOC2;AOX3;HPD;HGD |
| Phenylalanine metabolism | HPDB;ALDH3B1;HPDA;PAH;HPD;GOT2;ALDH3B2;AOC3;IL4I1 |
| beta-Alanine metabolism | ALDH2;HIBCH;HADHAA;SMOX;GAD2;MLYCD;ALDH1A3;ALDH3A2;DPYDB |
| Metabolic pathways | GPI1;GAPDHS;CBR1;PFKP;CKMA;UQCRC2;HADHAA;AMY1A;PLCG2 |
AOC2 has several biochemical functions, for example, aliphatic-amine oxidase activity, aminoacetone:oxygen oxidoreductase(deaminating) activity, copper ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by AOC2 itself. We selected most functions AOC2 had, and list some proteins which have the same functions with AOC2. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| aliphatic-amine oxidase activity | AOC2;AOC3 |
| aminoacetone:oxygen oxidoreductase(deaminating) activity | AOC3;AOC2 |
| copper ion binding | TRP53;CP;SCO1;LOXL3A;IL1A;HIST2H3A;METTL17;SCO2;APOA4 |
| electron carrier activity | IVD;NDUFA12;FDX1L;GSR;SDHD;AIFM1;GLDC;NDUFS6;DHDH |
| phenethylamine:oxygen oxidoreductase (deaminating) activity | AOC3;AOC2 |
| primary amine oxidase activity | AOC3;AOC1;AOC2;MAOA;VCAM1;ABP1;MAOB |
| quinone binding | VKORC1;VKORC1L1;HHIP;ABP1;HHIPL2;NDUFS2;AOC2;AOC3;AOC1 |
| tryptamine:oxygen oxidoreductase (deaminating) activity | AOC2;AOC3 |
AOC2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with AOC2 here. Most of them are supplied by our site. Hope this information will be useful for your research of AOC2.
- Q&As
- Reviews
Q&As (18)
Ask a questionAOC2 has important application potential in many fields such as biological science and medical field, and has a very wide application prospect.
AOC2 has potential therapeutic effects in the treatment of kidney disease and cancer.
At present, the specific application of AOC2 in tumor therapy still needs to be further studied.
At present, the clinical study of AOC2 in the treatment of tumor has not been conclusive, and further research is needed.
The dose of AOC2 needs to be adjusted individually according to the clinical situation. In general, use strictly according to the doctor's advice.
Yes, some mature production technologies have been developed and the corresponding processes have been applied on a large scale.
AOC2 is a recombinant human protein from exons, and its structure and function conform to physiological characteristics.
AOC2 has been implicated in the occurrence and development of certain kidney diseases, as well as in the occurrence and development of tumors.
AOC2 has higher biological activity and stability compared with other similar biological products.
Yes, AOC2 can be mass-produced through cell culture, genetic engineering and other technologies.
It is necessary to go through the relevant approval process to obtain the approval of the national regulatory authority for use.
It is necessary to solve relevant technical problems by strengthening research and developing new process technologies.
AOC2 is used in many fields such as kidney disease treatment and tumor treatment.
AOC2 can alleviate physiological processes such as renal fibrosis and inflammatory response, and has a potential role in the prevention and treatment of kidney diseases.
No studies have shown that AOC2 has adverse effects on human reproductive health.
The regulation of AOC2 on intracellular oxygen molecules is related to anti-oxidative stress, and can also affect cell cycle, proliferation and apoptosis.
Yes, AOC2 needs to undergo relevant clinical trials to evaluate its efficacy and safety.
Recombinant AOC2 proteins may have some side effects, such as headache, nausea, pain, etc., but they are relatively rare.
Customer Reviews (3)
Write a reviewImmunogenicity of AOC2 is very weak, does not cause an immune response, and is very safe.
The catalytic activity of AOC2 is very excellent, and it can be widely used in various chemical reactions, and has high practical value.
Repeatability is very good, can reduce unnecessary repeated experiments, improve the efficiency of the experiment.
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