APBB2
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Official Full Name
amyloid beta (A4) precursor protein-binding, family B, member 2
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Overview
The protein encoded by this gene interacts with the cytoplasmic domains of amyloid beta (A4) precursor protein and amyloid beta (A4) precursor-like protein 2. This protein contains two phosphotyrosine binding (PTB) domains, which are thought to function in signal transduction. Polymorphisms in this gene have been associated with Alzheimers disease. Alternative splicing results in multiple transcript variants. -
Synonyms
APBB2; amyloid beta (A4) precursor protein-binding, family B, member 2; amyloid beta A4 precursor protein-binding family B member 2; Fe65 like; FE65L; FE65L1; MGC35575; Amyloid beta (A4) precursor protein-binding, family B, member 2 (Fe65 like); Amyloid beta A4 precursor protein binding family B member 2; APBB 2; APBB2_HUMAN; Fe65 like protein; FE65L 1; Protein Fe65-like 1; Rirl 1; Rirl1; TR2 L; TR2L; Zfra; Zinc finger like protein; Fe65-like 1; OTTHUMP00000218167; OTTHUMP00000218168; OTTHUMP00000218169; OTTHUMP00000218170; OTTHUMP00000218869; OTTHUMP00000218871; OTTHUMP00000218876; OTTHUMP00000218877; OTTHUMP00000218879;
Species | Cat.# | Product name | Source (Host) | Tag | Protein Length | Price |
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Human | APBB2-8172H | Recombinant Human APBB2 protein, His & GST-tagged | E.coli | His/GST | Asp413~Pro758 (Accession# Q92870) | |
Human | APBB2-670H | Recombinant Human APBB2 protein, GST-tagged | Wheat Germ | GST | ||
Human | APBB2-8802HCL | Recombinant Human APBB2 293 Cell Lysate | HEK293 | N/A |
- Involved Pathway
- Protein Function
- Interacting Protein
APBB2 involved in several pathways and played different roles in them. We selected most pathways APBB2 participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with APBB2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name | Pathway Related Protein |
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APBB2 has several biochemical functions, for example, beta-amyloid binding, protein binding, transcription factor binding. Some of the functions are cooperated with other proteins, some of the functions could acted by APBB2 itself. We selected most functions APBB2 had, and list some proteins which have the same functions with APBB2. You can find most of the proteins on our site.
Function | Related Protein |
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beta-amyloid binding | APBB3;HSD17B10;NGFR;ITM2C;APOEA;GPRASP2;APBA2;FBXO2;PION |
protein binding | USP37;FAM212A;AASDHPPT;SLC22A6;CEP170L;ZBTB44;HPS1;APBB1;LRRC29 |
transcription factor binding | ZFPM1;PSMD4;YWHAZ;GNPTAB;PAX6;TRAPPC2;TAF7L;CAMTA2;JUNBB |
APBB2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with APBB2 here. Most of them are supplied by our site. Hope this information will be useful for your research of APBB2.
EGFR; APP; APLP2; HTT
- Q&As
- Reviews
Q&As (20)
Ask a questionIt is not known whether there is a direct relationship between APBB2 s and genetic factors, but complex genetic and environmental interactions may be involved.
The therapeutic effect of APBB2 may be dose-dependent, but the specific dose-response relationship needs further study.
The effect of APBB2 varies from patient to patient and may have some impact on daily life, but the specific situation needs to be evaluated on an individual basis.
Evaluating the efficacy of APBB2 usually requires clinical trials and animal studies to observe its impact on disease models and therapeutic efficacy.
APBB2 may have some potential as a target for new drug development, but further studies and validation are needed.
There is no clear link between the APBB2 and other brain diseases, but future research may reveal more.
The efficacy of recombinant APBB2 protein may vary over time, possibly due to factors such as its metabolism, clearance and receptor regulation in vivo.
The synthesis of APBB2 usually requires the introduction of APBB2 gene into the appropriate expression system through genetic engineering technology, and then obtained through expression and purification.
There may be a risk of recognition by the immune system and an immune response when treated with the APBB2, but this needs to be assessed on a case-by-case basis.
There have been no definite reports of side effects. However, more safety assessments are needed in research and clinical applications.
At present, there is no clear evidence that the APBB2 is used in the treatment of Alzheimer's disease, but the protein may have some potential applications in related research.
There are no clear reports of similar s with similar roles to APBB2, but future studies may uncover related proteins.
There are no confirmed reports of drugs related to APBB2 in clinical trials, but there may be future advances in related research.
APBB2 can be delivered through drug routes, such as injection, but the specific pathway needs to be further validated and optimized.
No clear replacement for the APBB2 has yet been found, but future research may reveal proteins with similar functions.
The estimated cost and time of developing APBB2 will involve many factors, including the strength of researchers, funds and technology, and it is difficult to give a specific estimate.
The APBB2 can serve as an important tool for studying nervous system function and related diseases, helping to gain insight into their mechanisms and search for potential treatments.
APBB2 has potential clinical applications in the treatment of neurosystem-related diseases, such as Alzheimer's disease.
APBB2 may influence nervous system function by regulating neuronal activity and synaptic function.
Although recombinant APBB2 protein may have some potential in the treatment of neurosystem-related diseases, its role in the treatment of other neurosystem-related diseases needs further investigation.
Customer Reviews (3)
Write a reviewLabeling effect of APBB2 showed excellent performance in Western blot, which can be used for fluorescence labeling.
Reproducibility of this APBB2 is very good, which can reduce unnecessary repeated experiments and improve experimental efficiency.
APBB2 produced by them is easy to preserve and has no problem in long-term preservation.
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