APBB3
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Official Full Name
amyloid beta (A4) precursor protein-binding, family B, member 3
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Overview
The protein encoded by this gene is a member of the APBB protein family. It is found in the cytoplasm and binds to the intracellular domain of the Alzheimers disease beta-amyloid precursor protein (APP) as well as to other APP-like proteins. It is thought that the protein encoded by this gene may modulate the internalization of APP. Multiple transcript variants encoding several different isoforms have been found for this gene. -
Synonyms
APBB3; amyloid beta (A4) precursor protein-binding, family B, member 3; amyloid beta A4 precursor protein-binding family B member 3; FE65L2; Amyloid beta A4 precursor protein binding family B member 3; amyloid beta precursor protein binding family B member 3; amyloid precursor interacting protein; APBB3_HUMAN; Fe65 like protein 2; MGC150555; MGC87674; Protein Fe65-like 2; SRA; FE65-like protein 2;
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Human
- Rat
- Rhesus Macaque
- E.coli
- E.Coli or Yeast
- HEK293
- In Vitro Cell Free System
- Mammalian Cell
- Wheat Germ
- GST
- His
- His (Fc)
- Avi
- His|T7
- N/A
| Species | Cat.# | Product name | Source (Host) | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| Human | APBB3-3439H | Recombinant Human APBB3, His-tagged | E.Coli or Yeast | His | 493 |
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| Human | APBB3-671H | Recombinant Human APBB3 protein, GST-tagged | Wheat Germ | GST |
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| Human | APBB3-9732H | Recombinant Human APBB3, GST-tagged | E.coli | GST | C-term-300a.a. | |
| Human | APBB3-8801HCL | Recombinant Human APBB3 293 Cell Lysate | HEK293 | N/A |
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| Human | APBB3-8800HCL | Recombinant Human APBB3 293 Cell Lysate | HEK293 | N/A |
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| Human | APBB3-1119HF | Recombinant Full Length Human APBB3 Protein, GST-tagged | In Vitro Cell Free System | GST | 486 amino acids |
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| Rat | Apbb3-3438R | Recombinant Rat Apbb3, His-tagged | E.Coli or Yeast | His | 504 |
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| Rat | Apbb3-8173R | Recombinant Rat Apbb3 protein, His & T7-tagged | E.coli | His/T7 | Asn14~Ala302 (Accession# O35827) |
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| Rat | APBB3-711R | Recombinant Rat APBB3 Protein | Mammalian Cell | His |
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| Rat | APBB3-367R-B | Recombinant Rat APBB3 Protein Pre-coupled Magnetic Beads | HEK293 |
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| Rat | APBB3-367R | Recombinant Rat APBB3 Protein, His (Fc)-Avi-tagged | HEK293 | His (Fc)-Avi |
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| Rhesus Macaque | APBB3-351R | Recombinant Rhesus monkey APBB3 Protein, His-tagged | Mammalian Cell | His |
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| Rhesus Macaque | APBB3-180R-B | Recombinant Rhesus Macaque APBB3 Protein Pre-coupled Magnetic Beads | HEK293 |
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| Rhesus Macaque | APBB3-180R | Recombinant Rhesus Macaque APBB3 Protein, His (Fc)-Avi-tagged | HEK293 | His (Fc)-Avi |
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- Involved Pathway
- Protein Function
- Interacting Protein
APBB3 involved in several pathways and played different roles in them. We selected most pathways APBB3 participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with APBB3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|
APBB3 has several biochemical functions, for example, beta-amyloid binding, protein binding, transcription factor binding. Some of the functions are cooperated with other proteins, some of the functions could acted by APBB3 itself. We selected most functions APBB3 had, and list some proteins which have the same functions with APBB3. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| beta-amyloid binding | ITM2C;APBB2;GPRASP2;COL25A1;TM2D1;HSD17B10;CD74;OLFM1;NGFR |
| protein binding | HGF;TUBA1A;HORMAD1;IRF9;SUMO3;AMY1B;NFIX;TCEB3B;RTP4 |
| transcription factor binding | SIX2;HDAC2;NR0B2;TFDP1A;HTT;PIAS2;RB1;E2F1;CCND1 |
APBB3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with APBB3 here. Most of them are supplied by our site. Hope this information will be useful for your research of APBB3.
DAPP1; PDPK1; EGFR; ERBB2; APP; RAB4A; APLP2
- Q&As
- Reviews
Q&As (20)
Ask a questionRecombinant Apbb3 protein supports neuronal maturation and function by regulating axon morphology, intercellular communication, and signal transduction.
The effects of Apbb3 injection on the nervous system include neuronal activity and the regulation of the external environment.
Some studies have shown that low expression of the recombinant Apbb3 protein is associated with the onset of neurodegenerative diseases.
Recombinant Apbb3 protein is one of the important therapeutic targets for neurodegenerative diseases, and related drug development is ongoing.
Recombinant Apbb3 protein can be used as an auxiliary test for clinical diagnosis of neurology and prediction of neurodegenerative diseases.
Several studies have shown that the Apbb3 can help restore cerebral ischemia-reperfusion injury in rats by promoting nervous system regeneration and protective effects.
Apbb3 can play a role in regulating glial interaction, participating in neuronal development and protecting physiological processes in neural processes.
Some studies have shown that the expression of Apbb3 is associated with the occurrence and progression of nervous system tumors.
Apbb3 is composed of multiple domains, different domains have different functions, including ligand binding, signal transduction and so on.
The Apbb3 regulates the activity of a variety of signaling pathways in the synapses of neurons.
The Apbb3 plays an important role in both synapses and cellular bodies of neurons to regulate the development and function of neurons.
Several studies have shown that the Apbb3 can play an important role in the plasticity of neuronal synapses.
Recombinant protein Apbb3 plays a role in the development of the nervous system by regulating signaling pathways between nerve cells and non-nerve cells.
The recombinant Apbb3 protein can interact with a variety of proteins, including neuronal transport proteins and neurotransmitter receptors.
In addition to neurodegenerative diseases, Apbb3 is also associated with other neurological diseases, such as brain trauma and stroke.
The recombinant Apbb3 protein plays an important role in neurodegenerative diseases such as Alzheimer's disease.
Several studies have shown that the recombinant Apbb3 protein can play an important role in the mouse model of rabbit spinal cord injury induced by BCG vaccine, including promoting the proliferation of neural stem cells.
Recombinant Apbb3 proteins are involved in a variety of biological processes, including neurodevelopment, signaling pathway regulation, and the development of neurodegenerative diseases.
Recombinant Apbb3 proteins are regulated by multiple signaling pathways, including transcription factors, phosphorylation, and natural products.
The recombinant Apbb3 protein is highly specific and sensitive, and can accurately identify the relevant protein in the serum of patients with neurodegenerative diseases.
Customer Reviews (4)
Write a reviewThe green production process of APBB2 realizes the minimization of waste and minimal impact on the environment, which truly achieves green production.
Reproducibility of APBB2 is very good, and the results are highly consistent regardless of the conditions under which it is tested or applied, demonstrating its excellent stability and reliability.
Short half-life and high clearance characteristics of APBB2 make it have greater potential in the treatment of tumors, infections and other diseases, and is expected to become a new generation of therapeutic drugs.
Catalytic activity of APBB2 is very excellent, which can greatly improve the rate and selectivity of chemical reactions, and its scientific research value is incomparable.
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