|Official Full Name||adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 2|
|Background||APPL2 is an isoform of APPL1 with 54% identity in their protein sequences. APPL2 has a role in cell proliferation and embryonic development. Recently, it was shown that APPL2 regulates FSH signaling and acts as a negative regulator in adiponectin signalin|
|Synonyms||APPL2; adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 2; DCC-interacting protein 13-beta; DIP13B; FLJ10659; DIP13 beta; adapter protein containing PH domain, PTB domain and leucine zipper motif 2|
|Species||Cat.#||Product name||Source (Host)||Tag||Protein Length||Price|
appl2 involved in several pathways and played different roles in them. We selected most pathways appl2 participated on our site, such as EGFR1 Signaling Pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with appl2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
|Pathway Name||Pathway Related Protein|
|EGFR1 Signaling Pathway||RALBB; RALBP1; ERRFI1; PITPNAA; MTA2; DNM1; STXBP1A; EPPK1; CEACAM1; GRB7|
appl2 has several biochemical functions, for example, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by appl2 itself. We selected most functions appl2 had, and list some proteins which have the same functions with appl2. You can find most of the proteins on our site.
|protein binding||LIN9; SPRR2A; FPR1; ATRNL1; NECAB2; LSM8; ARMC7; PPP1R8; SPSB4; WIPF2|
appl2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with appl2 here. Most of them are supplied by our site. Hope this information will be useful for your research of appl2.
APPL1; SUV39H2; RAB22A; MAPRE3; RAB5C