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APPL2

  • Official Full Name

    adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 2

  • Overview

    APPL2 is an isoform of APPL1 with 54% identity in their protein sequences. APPL2 has a role in cell proliferation and embryonic development. Recently, it was shown that APPL2 regulates FSH signaling and acts as a negative regulator in adiponectin signalin
  • Synonyms

    APPL2; adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 2; DCC-interacting protein 13-beta; DIP13B; FLJ10659; DIP13 beta; adapter protein containing PH domain, PTB domain and leucine zipper motif 2;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Antibody
  • Human
  • Mouse
  • Zebrafish
  • E.coli
  • HEK293
  • HEK293T
  • In Vitro Cell Free System
  • Insect Cell
  • Mammalian Cell
  • Wheat Germ
  • GST
  • His
  • Myc
  • DDK
  • N/A
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human APPL2-726H Recombinant Human APPL2 protein, GST-tagged Wheat Germ GST
Human APPL2-1002H Recombinant Human APPL2 Insect Cell N/A
Human APPL2-1003H Recombinant Human APPL2, His-tagged E.coli His
Human APPL2-28348TH Recombinant Human APPL2, His-tagged E.coli His
Human APPL2-8771HCL Recombinant Human APPL2 293 Cell Lysate HEK293 N/A
Human APPL2-4331H Recombinant Human APPL2 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human APPL2-1231HF Recombinant Full Length Human APPL2 Protein, GST-tagged In Vitro Cell Free System GST 664 amino acids
Human APPL2-28350TH Recombinant Human APPL2 N/A
Mouse Appl2-1668M Recombinant Mouse Appl2 Protein, Myc/DDK-tagged HEK293T Myc/DDK
Zebrafish APPL2-6803Z Recombinant Zebrafish APPL2 Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • APPL2 Related Articles

APPL2 involved in several pathways and played different roles in them. We selected most pathways APPL2 participated on our site, such as EGFR1 Signaling Pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with APPL2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
EGFR1 Signaling PathwayERRFI1;CRKL;ELF3;AP2A1;SH3BGRL;KRT7;TNK2;EPS8;RALBB

APPL2 has several biochemical functions, for example, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by APPL2 itself. We selected most functions APPL2 had, and list some proteins which have the same functions with APPL2. You can find most of the proteins on our site.

Function Related Protein
protein bindingH2-AB1;ACTR8;ASMTL;BCL11B;HIST1H2AM;ITGB7;MED8;CRIPT;MFAP4

APPL2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with APPL2 here. Most of them are supplied by our site. Hope this information will be useful for your research of APPL2.

APPL1; SUV39H2; RAB22A; MAPRE3; RAB5C

Cheng, KKY; Lam, KSL; et al. TRAF6-mediated ubiquitination of APPL1 enhances hepatic actions of insulin by promoting the membrane translocation of Akt. BIOCHEMICAL JOURNAL 455:207-216(2013).
King, GJ; Stockli, J; et al. Membrane Curvature Protein Exhibits Interdomain Flexibility and Binds a Small GTPase. JOURNAL OF BIOLOGICAL CHEMISTRY 287:40996-41006(2012).
  • Q&As
  • Reviews

Q&As (33)

Ask a question
Can APPL2 interact with other proteins involved in insulin signaling? 12/04/2022

Yes, APPL2 can interact with various proteins involved in insulin signaling, including IRS1 (insulin receptor substrate 1), AKT (protein kinase B), and AMPK (AMP-activated protein kinase). These interactions help regulate insulin signaling and downstream metabolic processes.

How does APPL2 contribute to insulin signaling? 10/19/2022

APPL2 acts as a scaffolding protein that interacts with insulin receptor and other signaling molecules to facilitate proper insulin signaling and glucose metabolism.

Can APPL2 influence cellular energy metabolism? 07/04/2022

Yes, APPL2 can influence cellular energy metabolism by regulating glucose uptake, glycogen synthesis, and fatty acid oxidation. It interacts with key signaling molecules in metabolic pathways to modulate energy homeostasis.

Can APPL2 be used as a diagnostic biomarker? 06/24/2022

APPL2 has shown potential as a biomarker in certain diseases, such as breast cancer. However, further research is needed to determine its diagnostic utility across various conditions.

Is APPL2 associated with any diseases? 02/14/2022

APPL2 has been implicated in several diseases, including cancer, insulin resistance, and neurodevelopmental disorders. Its dysregulation is often observed in these conditions.

Can APPL2 affect insulin secretion from pancreatic beta cells? 12/08/2021

Yes, APPL2 has been shown to play a role in insulin secretion from pancreatic beta cells. It interacts with proteins involved in insulin granule trafficking and exocytosis, contributing to regulated insulin secretion.

Can APPL2 be targeted for therapeutic purposes? 11/19/2021

While there are no current therapeutics targeting APPL2 specifically, understanding its role in various diseases may provide insights for developing targeted therapies in the future.

Are there any animal models or knockout studies related to APPL2? 06/09/2021

Yes, animal models and knockout studies have been conducted to investigate the role of APPL2 in various biological processes and diseases. For example, APPL2 knockout mice have shown altered insulin signaling and glucose metabolism. These models provide valuable insights into the function of APPL2 in vivo.

Does APPL2 play a role in autophagy? 01/27/2021

Yes, APPL2 is involved in the regulation of autophagy. It interacts with components of the autophagy machinery and can modulate autophagy induction and autophagosome formation. APPL2's role in autophagy suggests its involvement in cellular recycling and maintenance processes.

Are there any known interacting partners of APPL2? 10/28/2020

APPL2 can interact with multiple proteins, including receptors, kinases, and scaffolding proteins, such as insulin receptor, AKT, and Rab5. These interactions contribute to its role in signaling and vesicle trafficking.

Are there any known small molecules or compounds that can regulate APPL2 activity? 05/07/2020

Currently, there are no known small molecules or compounds specifically targeting APPL2 activity. Future studies may uncover potential modulators of APPL2 function that could be utilized for therapeutic purposes.

Can APPL2 serve as a biomarker for any diseases? 03/16/2020

Currently, there are no established biomarkers utilizing APPL2. However, ongoing research may identify specific disease contexts in which APPL2 expression levels or activity could be used as a potential biomarker.

Does APPL2 have any role in cellular stress response? 02/24/2020

APPL2 has been implicated in cellular stress response pathways, such as the unfolded protein response (UPR) and oxidative stress response. It modulates the signaling and cellular adaptations that occur during stress conditions.

Is APPL2 expression regulated in a tissue-specific manner? 01/18/2020

Yes, APPL2 expression can be regulated in a tissue-specific manner. It is expressed in various tissues, including adipose tissue, liver, skeletal muscle, and brain. APPL2 levels may vary in different tissues depending on metabolic and physiological conditions.

What are the downstream effects of APPL2 dysregulation in cancer? 01/02/2020

Dysregulation of APPL2 in cancer can lead to enhanced cell proliferation, survival, and invasion. It can also impact tumor growth, metastasis, and response to therapy.

Can APPL2 influence cell migration and invasion? 12/19/2019

Yes, APPL2 can influence cell migration and invasion. It has been shown to regulate cell migration in various cellular contexts, including cancer cell migration and immune cell migration. APPL2's interactions with signaling molecules involved in cell motility contribute to these processes.

How does APPL2 contribute to vesicle trafficking? 08/26/2019

APPL2 interacts with proteins involved in vesicle trafficking, such as Rab5, and regulates endosomal trafficking, exocytosis, and endocytosis. It influences membrane and protein dynamics within cells.

Does APPL2 play a role in neuronal development? 07/27/2019

Yes, APPL2 is involved in neuronal development and synaptic plasticity. It modulates neurotransmitter release and receptor trafficking, contributing to neuronal function and connectivity.

Are there any known genetic mutations or polymorphisms in the APPL2 gene? 07/02/2019

Genetic mutations or polymorphisms in the APPL2 gene have not been extensively studied. Further research is needed to explore potential genetic variations and their effects on APPL2 function and disease susceptibility.

Are there any diseases or disorders associated with APPL2 dysfunction? 05/07/2019

APPL2 dysfunction has been implicated in various diseases and disorders. It has been associated with insulin resistance, obesity, type 2 diabetes, cardiovascular diseases, and certain types of cancer. Understanding APPL2's role in these conditions may offer potential therapeutic targets.

Are there any drugs targeting APPL2? 03/30/2019

Currently, there are no drugs specifically targeting APPL2. However, given its involvement in disease processes, it remains a potential target for future therapeutic interventions.

Does APPL2 interact with other signaling pathways besides insulin signaling? 08/13/2018

Yes, APPL2 can interact with several signaling pathways besides insulin signaling, including the mTOR (mechanistic target of rapamycin) pathway, Wnt signaling, and ERK (extracellular signal-regulated kinase) signaling. These interactions suggest that APPL2 may have broader regulatory roles beyond insulin signaling.

Does APPL2 have any role in immune response? 05/29/2018

APPL2 has been implicated in immune response regulation. It can modulate cytokine production and immune cell function by interacting with signaling molecules involved in immune signaling pathways. APPL2's function in immune response may have implications for various immunological conditions and diseases.

Is APPL2 expression regulated by any factors or signaling pathways? 04/16/2018

Yes, APPL2 expression can be regulated by various factors, including growth factors, cytokines, and cellular stress. Signaling pathways like the PI3K/AKT pathway can also modulate APPL2 expression.

Which signaling pathways does APPL2 regulate? 03/21/2018

APPL2 is involved in various signaling pathways, including insulin signaling, growth factor signaling, and neuronal development pathways.

Is APPL2 involved in DNA repair processes? 12/02/2017

APPL2 has been implicated in DNA repair processes. It interacts with proteins involved in DNA damage repair pathways and can modulate DNA repair and genomic stability. APPL2's involvement in DNA repair suggests its role in maintaining genome integrity.

How is APPL2 involved in neuronal development? 07/03/2017

APPL2 is involved in various aspects of neuronal development. It has been implicated in neurite outgrowth and axon guidance, as well as synaptic plasticity and neurotransmission. APPL2 interacts with proteins involved in these processes, contributing to proper neuronal development and function.

Does APPL2 have any known functional domains? 06/10/2017

Yes, APPL2 contains multiple functional domains, including a phosphotyrosine-binding (PTB) domain, a pleckstrin homology (PH) domain, and a leucine zipper (LZ) domain, which contribute to its interactions and functionalities.

Does APPL2 have any isoforms? 06/09/2017

Yes, APPL2 has two known isoforms produced by alternative splicing, known as APPL2a and APPL2b. These isoforms can differ in their cellular localization and functions.

Does APPL2 have any role in adipocyte biology? 06/02/2017

Yes, APPL2 is involved in adipocyte biology. It can modulate adipogenesis (the process of adipocyte differentiation) and lipid metabolism. APPL2 expression may affect adipose tissue function and whole-body energy balance.

How is APPL2 involved in insulin resistance? 05/13/2017

APPL2 can regulate insulin sensitivity by modulating insulin receptor signaling and glucose uptake. Dysregulated APPL2 expression or function can contribute to insulin resistance and impaired glucose homeostasis.

Can APPL2 affect cellular proliferation and survival? 12/05/2016

Yes, APPL2 can affect cellular proliferation and survival. It interacts with proteins involved in cell cycle regulation, apoptosis, and DNA damage response pathways. APPL2's involvement in these processes suggests its potential role in cell growth and survival control.

Can APPL2 regulate cell polarity and organization? 07/13/2016

Yes, APPL2 can regulate cell polarity and organization. It interacts with polarity proteins and contributes to cell polarity establishment and maintenance. APPL2's function in cell polarity suggests its role in cellular organization and tissue development.

Customer Reviews (4)

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Reviews
12/27/2020

    In addition to its scientific advantages, the manufacturer of the APPL2 protein stands out for their exceptional support and assistance.

    11/05/2020

      Their technical expertise and prompt customer service have been instrumental in resolving any challenges or questions I encountered throughout my research journey.

      11/11/2018

        Its ability to modulate the activity of essential signaling pathways involved in these processes makes it a valuable tool for unraveling their complexities.

        07/15/2016

          It can be effectively employed in in vitro and in vivo studies, offering insights into the intricate mechanisms underlying angiogenesis, lipid metabolism, and cardiovascular diseases.

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