Recombinant Human APPL2 protein, GST-tagged
Cat.No. : | APPL2-726H |
Product Overview : | Human APPL2 full-length ORF ( AAH33731.1, 1 a.a. - 664 a.a.) recombinant protein with GST-tag at N-terminal. |
- Specification
- Gene Information
- Related Products
Description : | The protein encoded by this gene is one of two effectors of the small GTPase RAB5A/Rab5, which are involved in a signal transduction pathway. Both effectors contain an N-terminal Bin/Amphiphysin/Rvs (BAR) domain, a central pleckstrin homology (PH) domain, and a C-terminal phosphotyrosine binding (PTB) domain, and they bind the Rab5 through the BAR domain. They are associated with endosomal membranes and can be translocated to the nucleus in response to the EGF stimulus. They interact with the NuRD/MeCP1 complex (nucleosome remodeling and deacetylase /methyl-CpG-binding protein 1 complex) and are required for efficient cell proliferation. A chromosomal aberration t(12;22)(q24.1;q13.3) involving this gene and the PSAP2 gene results in 22q13.3 deletion syndrome, also known as Phelan-McDermid syndrome. [provided by RefSeq, Oct 2011] |
Source : | Wheat Germ |
Species : | Human |
Tag : | GST |
Molecular Mass : | 100.9 kDa |
AA Sequence : | MPAVDKLLLEEALQDSPQTRSLLSV FEEDAGTLTDYTNQLLQAMQRVYGA QNEMCLATQQLSKQLLAYEKQNFAL GKGDEEVISTLHYFSKVVDELNLLH TELAKQLADTMVLPIIQFREKDLTE VSTLKDLFGLASNEHDLSMAKYSRL PKKKENEKVKTEVGKEVAAARRKQH LSSLQYYCALNALQYRKQMAMMEPM IGFAHGQINFFKKGAEMFSKRMDSF LSSVADMVQSIQVELEAEAEKMRVS QQELLSVDESVYTPDSDVAAPQINR NLIQKAGYLNLRNKTGLVTTTWERL YFFTQGGNLMCQPRGAVAGGLIQDL DNCSVMAVDCEDRRYCFQITTPNGK SGIILQAESRKENEEWICAINNISR QIYLTDNPEAVAIKLNQTALQAVTP ITSFGKKQESSCPSQNLKNSEMENE NDKIVPKVTASLPEAEELIAPGTPI QFDIVLPATEFLDQNRGSRRTNPFG ETEDESFPEAEDSLLQQMFIVRFLG SMAVKTDSTTEVIYEAMRQVLAARA IHNIFRMTESHLMVTSQSLRLIDPQ TQVSRANFELTSVTQFAAHQENKRL VGFVIRVPESTGEESLSTYIFESNS EGEKICYAINLGKEIIEVQKDPEAL AQLMLSIPLTNDGKYVLLNDQPDDD DGNPNEHRGAESEA |
Applications : | Enzyme-linked Immunoabsorbent Assay; Western Blot (Recombinant protein); Antibody Production; Protein Array |
Notes : | Best use within three months from the date of receipt of this protein. |
Storage : | Store at -80 centigrade. Aliquot to avoid repeated freezing and thawing. |
Storage Buffer : | 50 mM Tris-HCI, 10 mM reduced Glutathione, pH=8.0 in the elution buffer. |
Gene Name : | APPL2 adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 2 [ Homo sapiens ] |
Official Symbol : | APPL2 |
Synonyms : | APPL2; adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 2; DCC-interacting protein 13-beta; DIP13B; FLJ10659; DIP13 beta; adapter protein containing PH domain, PTB domain and leucine zipper motif 2; |
Gene ID : | 55198 |
mRNA Refseq : | NM_001251904 |
Protein Refseq : | NP_001238833 |
MIM : | 606231 |
UniProt ID : | Q8NEU8 |
Products Types
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◆ Lysates | ||
APPL2-8771HCL | Recombinant Human APPL2 293 Cell Lysate | +Inquiry |
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For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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