ARAF

  • Official Full Name

    v-raf murine sarcoma 3611 viral oncogene homolog

  • Overview

    A-Raf, B-Raf and c-Raf (Raf-1) are the main effectors recruited by GTP-bound Ras to activate the MEK-MAP kinase pathway. Activation of c-Raf is the best understood and involves phosphorylation at multiple activating sites including Ser338, Tyr341, Thr491,
  • Synonyms

    ARAF; v-raf murine sarcoma 3611 viral oncogene homolog; ARAF1, v raf murine sarcoma 3611 viral oncogene homolog 1; serine/threonine-protein kinase A-Raf; Oncogene ARAF1; proto-oncogene Pks; proto-oncogene A-Raf-1; Ras-binding protein DA-Raf; v-raf murine;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Antibody
  • Protein Pre-coupled Magnetic Beads
  • Human
  • Mouse
  • Zebrafish
  • E.coli
  • HEK293
  • HEK293T
  • In Vitro Cell Free System
  • Insect Cell
  • Mamanlian cells
  • Mammalian Cell
  • Wheat Germ
  • Flag
  • GST
  • His
  • His (Fc)
  • Avi
  • Myc
  • DDK
  • MYC
  • Myc|DDK
  • N/A
  • N
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human ARAF-186H Recombinant Human ARAF protein, His-tagged E.coli His
Human ARAF-504H Active Recombinant Human ARAF (YY301, 302DD) Mutation Protein, GST/His-tagged Insect Cell GST/His
Human ARAF-32H Recombinant Human ARAF protein, GST-tagged Insect Cell GST
Human ARAF-398H Recombinant Human ARAF protein, MYC/DDK-tagged HEK293 Myc/DDK
Human ARAF-187H Recombinant Human ARAF protein, GST-tagged E.coli GST
Human ARAF-738H Recombinant Human ARAF protein, GST-tagged Wheat Germ GST
Human ARAF-105HCL Recombinant Human ARAF cell lysate N/A
Human ARAF-239H Recombinant Human ARAF Protein, His-tagged E.coli N-His
Human ARAF-3790H Recombinant Human ARAF Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human ARAF-7139HFL Recombinant Full Length Human ARAF protein, Flag-tagged Mamanlian cells Flag
Human ARAF-26034TH Recombinant Human ARAF N/A
Human ARAF-1524HF Recombinant Full Length Human ARAF Protein, GST-tagged In Vitro Cell Free System GST
Mouse ARAF-1831M Recombinant Mouse ARAF Protein Mammalian Cell His
Mouse ARAF-654M Recombinant Mouse ARAF Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse Araf-823M Recombinant Mouse Araf Protein, MYC/DDK-tagged HEK293T MYC/DDK
Mouse ARAF-654M-B Recombinant Mouse ARAF Protein Pre-coupled Magnetic Beads HEK293
Zebrafish ARAF-11758Z Recombinant Zebrafish ARAF Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • ARAF Related Articles
  • ARAF Related Research Area

ARAF involved in several pathways and played different roles in them. We selected most pathways ARAF participated on our site, such as ErbB signaling pathway, FoxO signaling pathway, Vascular smooth muscle contraction, which may be useful for your reference. Also, other proteins which involved in the same pathway with ARAF were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
ErbB signaling pathwayPRKCB;ELK1;CAMK2A;PRKCBB;NRAS;AKT2;MAPK8B;SHC3;MAPK8A
FoxO signaling pathwayFOXO1;PDPK1B;PIK3R1;PRMT1;MDM2;PIK3R2;G6PC2;SOD2;BRAF
Vascular smooth muscle contractionMAPK3;RHOAB;CALD1B;CALD1;ACTG2;AVPR1B;PRKCBA;CALM3;PRKCD
Natural killer cell mediated cytotoxicityIFNA12;NCR3;PIK3CA;PRKCA;Ifna11;VAV3;RAET1L;MAP2K1;LCP2
Long-term potentiationHRAS;ITPR1;CALM1;CALML5;GRIA2;CAMK2B;MAP2K1;MAPK3;CALM2
Serotonergic synapseCYP4X1;GNG10;PRKACG;GNG4;TRPC1;PRKCA;GNAI1;SLC18A1;MAOA
Long-term depressionPLCB1;MAPK3;GRIA1;GNAI2;KRAS;GNAO1;GNA13;PRKG1;HRAS
Regulation of actin cytoskeletonPXN;PPP1R12A;ARHGEF7A;ITGB2L;FGF11;PPP1R12C;NRAS;ITGA2B;ABI2B
Insulin signaling pathwayPPP1CAB;PRKAR2A;PRKAR2AB;FBP2;GSK3B;PPP1R3CA;PRKAA2;PIK3R3A;RPS6KB1
Progesterone-mediated oocyte maturationIGF1RA;GNAI2A;MAPK14A;MAPK9;PIK3CG;CCNA1;IGF1R;RAF1;MAP2K1
AlcoholismHIST1H2BK;HIST1H4E;GNAI3;H3F3C;SLC6A3;ARAF;GRIN2C;MAOB;HIST1H4B
Hepatitis CPPP2R2C;IRF1;PPP2R2D;TBK1;TP53;PPP2CA;LDLR;IFIT1;SCARB1
Pathways in cancerTPM3;FGF21;IL6;MMP1;BID;FGF10;TCEB2;PRKACB;SMO
Proteoglycans in cancerKRAS;THBS1;MAPK12;WNT7A;HOXD10;NANOG;WNT8A;DDX5;TGFB1
Colorectal cancerRALGDS;PIK3R2;MLH1;BCL2;APC;FOS;PIK3R5;MAPK1;PIK3CA
Renal cell carcinomaHIF1A;FLCN;EP300;AHA-1;TGFB2;PAK7;MAP2K2;SLC2A1;VEGFA
Pancreatic cancerARAF;CDC42;IKBKB;AKT1;TGFBR1;RALGDS;STAT3;NFKB1;RAC2
Endometrial cancerPIK3CD;PDPK1;PIK3R3;PIK3CG;APC2;TP53;AKT2;SOS1;CTNNA3
GliomaCAMK2G;PDGFB;AKT1;CALM4;PLCG1;CAMK2A;MAP2K2;CALML5;PRKCB
Prostate cancerHSP90AB1;CCND1;BRAF;FGFR2;AKT1;PDGFRA;Pdgfa&Pdgfb;SRD5A2;PIK3R3
MelanomaFGF4;FGF11;Pdgfa&Pdgfb;MAP2K1;FGF12;PIK3R1;PIK3R3;FGF19;FGF1
Bladder cancerMMP1A;E2F3;RASSF1;UPK3A;DAPK2;RAF1;KRAS;CCND1;CDH1
Chronic myeloid leukemiaPIK3CG;MAPK3;CCND1;RAF1;PIK3R5;SMAD4;PIK3R1;GRB2;HRAS
Acute myeloid leukemiaPIK3R1;NRAS;STAT5B;JUP;PIK3CB;TCF7;MAPK3;SOS1;BAD
Non-small cell lung cancerPIK3R2;PIK3R5;PLCG1;PIK3R1;MAPK3;RASSF5;SOS1;GRB2;AKT1

ARAF has several biochemical functions, for example, ATP binding, metal ion binding, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by ARAF itself. We selected most functions ARAF had, and list some proteins which have the same functions with ARAF. You can find most of the proteins on our site.

Function Related Protein
ATP bindingDNAJA2;SYN2;BLM;PRKY;MAP4K6;CAMKK1B;ABCA7;PLK4;AURKA
metal ion bindingATP2C2;PARN;SOBPB;SDHD;GMPR;PDZRN3B;CALM4;SHRPRBCK1R;ZIC2B
protein bindingMAF;CHD8;NOL4;C22orf23;ZBED3;KIAA1530;SLX4;ARHGAP24;YOD1
protein kinase activityPAK1;FYNA;ULK1A;NEK1;PAK4;EPHB2B;EK1;ERBB4A;MAP3K11
protein serine/threonine kinase activityTTBK2;TNIK;PKN2;RAF1;LRRK2;SMOK3B;STK16;CDK14;PLK2
receptor signaling protein activityARAF;DOK2;FCGR1A;cgr2b;DOK1;RGS12;DAXX;BAG4;KLK1B4

ARAF has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ARAF here. Most of them are supplied by our site. Hope this information will be useful for your research of ARAF.

MAP2K2; YWHAZ; HSP90AB1; YWHAG

Yu, L; Yu, CJ; et al. Structural analysis of galactoarabinan from duckweed. CARBOHYDRATE POLYMERS 117:807-812(2015).
Sumiyoshi, M; Nakamura, A; et al. Increase in Cellulose Accumulation and Improvement of Saccharification by Overexpression of Arabinofuranosidase in Rice. PLOS ONE 8:-(2013).
  • Q&As
  • Reviews

Q&As (24)

Ask a question
Are there any specific cancer types where dysregulation of the ARAF protein is commonly observed? 02/19/2023

Dysregulation of the ARAF protein is predominantly found in certain cancer types, including melanoma, colorectal cancer, lung cancer, and thyroid cancer. Mutations or alterations in the ARAF gene can occur, resulting in its dysregulated activity and contributing to the development and progression of these cancers.

Are there any specific cancer types where dysregulation of the ARAF protein is commonly observed? 02/19/2023

Dysregulation of the ARAF protein is predominantly found in certain cancer types, including melanoma, colorectal cancer, lung cancer, and thyroid cancer. Mutations or alterations in the ARAF gene can occur, resulting in its dysregulated activity and contributing to the development and progression of these cancers.

Are there any known drugs that target the ARAF protein? 02/14/2023

Yes, several small molecule inhibitors that target the ARAF protein have been developed, such as sorafenib and RAF265. These drugs are primarily used in targeted cancer therapies and are designed to inhibit abnormal ARAF signaling in cancer cells.

Is the ARAF protein known to have any non-cancer-related functions? 10/04/2022

Although the ARAF protein is primarily studied in the context of cancer and signaling pathways, it is also believed to have non-cancer-related functions. It may be involved in processes like neuronal development, cardiac function, and immune responses. Further research is needed to fully understand the breadth of its functions.

Is the ARAF protein known to have any non-cancer-related functions? 10/04/2022

Although the ARAF protein is primarily studied in the context of cancer and signaling pathways, it is also believed to have non-cancer-related functions. It may be involved in processes like neuronal development, cardiac function, and immune responses. Further research is needed to fully understand the breadth of its functions.

Can the ARAF protein be targeted for drug development? 08/01/2021

Yes, the ARAF protein can be targeted for drug development. Small molecule inhibitors that specifically block the kinase activity of ARAF have been developed and studied as potential anti-cancer agents. These inhibitors aim to selectively inhibit abnormal ARAF signaling in cancer cells, while sparing normal cells.

How does the ARAF protein interact with other proteins in the MAPK/ERK pathway? 07/01/2021

The ARAF protein interacts with other proteins in the MAPK/ERK pathway to transmit signals and activate downstream effectors. It can form complexes with upstream proteins, such as growth factor receptors, to initiate signaling cascades. Additionally, it can interact with other kinases, scaffolding proteins, and adaptors to coordinate and amplify the signaling events.

How does the ARAF protein interact with other proteins in the MAPK/ERK pathway? 07/01/2021

The ARAF protein interacts with other proteins in the MAPK/ERK pathway to transmit signals and activate downstream effectors. It can form complexes with upstream proteins, such as growth factor receptors, to initiate signaling cascades. Additionally, it can interact with other kinases, scaffolding proteins, and adaptors to coordinate and amplify the signaling events.

How can research on the ARAF protein contribute to the development of novel therapeutic strategies? 12/24/2018

Research on the ARAF protein can provide insights into its role in cancer development and signaling pathways. By understanding the molecular mechanisms of ARAF activation and its interactions with other proteins, novel therapeutic strategies can be developed. This knowledge can inform the design of more effective ARAF inhibitors, combination therapies, or alternative approaches to target ARAF dysregulation in cancer cells.

How can research on the ARAF protein contribute to the development of novel therapeutic strategies? 12/24/2018

Research on the ARAF protein can provide insights into its role in cancer development and signaling pathways. By understanding the molecular mechanisms of ARAF activation and its interactions with other proteins, novel therapeutic strategies can be developed. This knowledge can inform the design of more effective ARAF inhibitors, combination therapies, or alternative approaches to target ARAF dysregulation in cancer cells.

How is the ARAF protein implicated in cancer development? 04/21/2018

The ARAF protein can contribute to cancer development through different mechanisms. Activating mutations in the ARAF gene can lead to aberrant activation of the MAPK/ERK signaling pathway, promoting uncontrolled cell growth, survival, and metastasis. Additionally, dysregulation of ARAF signaling can affect other cellular processes and contribute to tumor progression.

Does the ARAF protein have any role in normal development or tissue homeostasis? 03/04/2018

Yes, the ARAF protein plays a role in normal cellular processes and tissue homeostasis. It is involved in various developmental pathways and tissue-specific signaling cascades, contributing to normal growth, differentiation, and maintenance of tissues and organs.

Are there any ongoing clinical trials targeting the ARAF protein? 09/24/2017

There are ongoing clinical trials investigating the effectiveness and safety of ARAF inhibitors in cancer treatment. These trials are evaluating the potential of ARAF inhibitors as targeted therapies in specific cancer types and patient populations.

Are there any known diseases associated with mutations in the ARAF gene? 06/26/2017

Yes, mutations in the ARAF gene have been identified in some rare genetic disorders. For example, germline ARAF mutations have been linked to Noonan syndrome, a genetic condition characterized by abnormal facial features, heart defects, short stature, and developmental delays.

Are there any ongoing clinical trials targeting the ARAF protein for cancer treatment? 06/01/2017

Currently, there are no clinical trials specifically targeting the ARAF protein for cancer treatment listed on clinical trial databases like ClinicalTrials.gov. However, there may be preclinical studies or ongoing research investigating the potential of targeting ARAF in cancer therapy.

Are there any ongoing clinical trials targeting the ARAF protein for cancer treatment? 06/01/2017

Currently, there are no clinical trials specifically targeting the ARAF protein for cancer treatment listed on clinical trial databases like ClinicalTrials.gov. However, there may be preclinical studies or ongoing research investigating the potential of targeting ARAF in cancer therapy.

How common are ARAF mutations in cancer patients? 04/28/2017

ARAF mutations are relatively rare compared to other genes in the MAP kinase pathway, such as BRAF or KRAS. The frequency of ARAF mutations in cancer patients varies depending on the cancer type. For example, ARAF mutations are found in approximately 1-2% of melanomas and less frequently in other cancer types.

How common are ARAF mutations in cancer patients? 04/28/2017

ARAF mutations are relatively rare compared to other genes in the MAP kinase pathway, such as BRAF or KRAS. The frequency of ARAF mutations in cancer patients varies depending on the cancer type. For example, ARAF mutations are found in approximately 1-2% of melanomas and less frequently in other cancer types.

Are there any known side effects or limitations associated with targeting the ARAF protein for therapy? 01/07/2017

Targeting the ARAF protein for therapy can have potential side effects and limitations. Since ARAF is involved in various cellular processes, inhibiting its activity can impact normal cell functions and lead to adverse effects. Additionally, resistance mechanisms can arise, rendering ARAF inhibitors less effective over time. Careful monitoring and combination therapies may be necessary to minimize side effects and overcome resistance.

Are there any known side effects or limitations associated with targeting the ARAF protein for therapy? 01/07/2017

Targeting the ARAF protein for therapy can have potential side effects and limitations. Since ARAF is involved in various cellular processes, inhibiting its activity can impact normal cell functions and lead to adverse effects. Additionally, resistance mechanisms can arise, rendering ARAF inhibitors less effective over time. Careful monitoring and combination therapies may be necessary to minimize side effects and overcome resistance.

What are the potential clinical applications of targeting the ARAF protein? 12/16/2016

Targeting the ARAF protein could have potential clinical applications in cancer therapy. Mutations or dysregulation of the ARAF gene have been found in certain cancers, and inhibiting ARAF activity with specific inhibitors may help control tumor growth or sensitize cancer cells to other treatment modalities.

Can the ARAF protein be targeted for personalized medicine approaches? 11/28/2016

Yes, the ARAF protein can be targeted in personalized medicine approaches. By identifying specific mutations or dysregulation in the ARAF gene, treatment strategies can be tailored to individual patients. This allows for the selection of therapeutic options that specifically target the abnormal ARAF signaling in each patient's cancer, potentially improving treatment outcomes.

Can the ARAF protein be targeted for personalized medicine approaches? 11/28/2016

Yes, the ARAF protein can be targeted in personalized medicine approaches. By identifying specific mutations or dysregulation in the ARAF gene, treatment strategies can be tailored to individual patients. This allows for the selection of therapeutic options that specifically target the abnormal ARAF signaling in each patient's cancer, potentially improving treatment outcomes.

Can the ARAF protein be used as a biomarker for certain diseases? 10/14/2016

The ARAF protein itself is not commonly used as a biomarker for disease diagnosis or prognosis. However, the presence or activity of ARAF, along with other components of the MAPK/ERK signaling pathway, may be assessed in certain cancer types to guide treatment decisions or assess treatment response.

Customer Reviews (8)

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Reviews
01/17/2023

    Its unique characteristics contribute to obtaining clear and detailed structural information, enabling researchers to unravel the intricate complexities of protein interactions and conformational changes.

    08/17/2022

      The high-quality ARAF protein available from reliable manufacturers ensures accurate detection and quantification of ANO4 protein levels in samples, providing valuable insights into its biological roles and signaling pathways.

      05/24/2022

        In addition to their expertise, the manufacturer's technical support team can assist in troubleshooting and optimizing the handling and application of the ARAF protein.

        10/28/2021

          Its reliable and accurate performance ensures dependable results, contributing to the advancement of scientific knowledge in various disciplines.

          10/26/2020

            In WB experiments, ARAF protein exhibits exceptional performance, making it an ideal tool for studying ANO4 protein expression, regulation, and potential functional changes.

            09/04/2020

              ARAF protein demonstrates great utility in protein electron microscopy structure analysis.

              04/19/2020

                By relying on the ARAF protein and the manufacturer's exceptional technical support, researchers can confidently pursue their experimental goals while knowing they have access to reliable resources and expert guidance.

                04/15/2016

                  The use of ARAF protein in this technique allows researchers to explore the intricate three-dimensional structure of the protein at a molecular level.

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