ARAF

  • Official Full Name

    v-raf murine sarcoma 3611 viral oncogene homolog
  • Overview

    A-Raf, B-Raf and c-Raf (Raf-1) are the main effectors recruited by GTP-bound Ras to activate the MEK-MAP kinase pathway. Activation of c-Raf is the best understood and involves phosphorylation at multiple activating sites including Ser338, Tyr341, Thr491,
  • Synonyms

    ARAF;v-raf murine sarcoma 3611 viral oncogene homolog;ARAF1, v raf murine sarcoma 3611 viral oncogene homolog 1;serine/threonine-protein kinase A-Raf;Oncogene ARAF1;proto-oncogene Pks;proto-oncogene A-Raf-1;Ras-binding protein DA-Raf;v-raf murine

Recombinant Proteins

  • Human
  • Zebrafish
  • Mouse
  • E.coli
  • Mammalian Cells
  • Insect Cells
  • HEK293
  • Wheat Germ
  • In Vitro Cell Free System
  • His
  • GST
  • DDK
  • Myc
  • Non
  • Avi
  • Fc
  • Flag
Cat.# Product name Source (Host) Species Tag Protein Length Price
ARAF-186H Recombinant Human ARAF protein, His-tagged E.coli Human His 225 - 324 aa
ARAF-187H Recombinant Human ARAF protein, GST-tagged E.coli Human GST 225-324 a.a.
ARAF-11758Z Recombinant Zebrafish ARAF Mammalian Cells Zebrafish His
ARAF-1831M Recombinant Mouse ARAF Protein Mammalian Cells Mouse His
ARAF-32H Recombinant Human ARAF protein, GST-tagged Insect Cells Human GST 209-end a.a.
ARAF-398H Recombinant Human ARAF protein, MYC/DDK-tagged HEK293 Human DDK&Myc
ARAF-504H Active Recombinant Human ARAF (YY301, 302DD) Mutation Protein, GST/His-tagged Insect Cells Human GST&His aRAF (GST-282-606(end)-His)
ARAF-738H Recombinant Human ARAF protein, GST-tagged Wheat Germ Human GST
ARAF-105HCL Recombinant Human ARAF cell lysate Human Non
ARAF-1524HF Recombinant Full Length Human ARAF Protein, GST-tagged In Vitro Cell Free System Human GST Full L. 606 amino acids
ARAF-239H Recombinant Human ARAF Protein, His-tagged E.coli Human His Gln349-Pro606
ARAF-26034TH Recombinant Human ARAF Human Non 282-606 a.a.
ARAF-3790H Recombinant Human ARAF Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293 Human DDK&Myc
ARAF-654M Recombinant Mouse ARAF Protein, His (Fc)-Avi-tagged HEK293 Mouse Avi&Fc&His
ARAF-654M-B Recombinant Mouse ARAF Protein Pre-coupled Magnetic Beads HEK293 Mouse
ARAF-7139HFL Recombinant Full Length Human ARAF protein, Flag-tagged Mammalian Cells Human Flag Full L.
Araf-823M Recombinant Mouse Araf Protein, MYC/DDK-tagged HEK293 Mouse DDK&Myc

    Involved Pathway

    ARAF involved in several pathways and played different roles in them. We selected most pathways ARAF participated on our site, such as ErbB signaling pathway,FoxO signaling pathway,Vascular smooth muscle contraction, which may be useful for your reference. Also, other proteins which involved in the same pathway with ARAF were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Endometrial cancer MAP2K1,CTNNA2,BRAF,MAPK1,TCF7,FOXO3,ILK,ERBB2,PIK3CD,CDH1
    Long-term potentiation GRIN2A,CALM4,CAMK2A,CAMK2G,GRIN1,CALML3,GRIN2C,PLCB1,CALM3,CAMK2B
    Bladder cancer DAPK3,IL-8,VEGFA,CDKN2A,MAPK3,CCND1,MMP9,THBS1,MDM2,EGF
    Colorectal cancer GSK3B,TCF7L2,AKT2,BRAF,RALGDS,AKT1,MAPK8,BIRC5,PIK3R2,PIK3CD
    Pathways in cancer F2RL3,GNAI3,ARNT2,PLCG2,AXIN1,FGF19,CASP9,TPM3,STAT3,NFKB1
    Natural killer cell mediated cytotoxicity TNFRSF10C,PIK3R5,IFNA1,ULBP1,ZAP70,NCR1,PAK1,LCP2,HLA-E,KLRC4-KLRK1
    Insulin signaling pathway PHKA1,CALM2,PRKAG3,PRKCI,SOCS3,RPS6,PRKCZ,CALM1A,PRKAR2AB,PRKAB1
    Regulation of Actin Cytoskeleton PAK1,ACTN2B,BRAF,ITGA11A,GSN,GSNB,RHOAD,FGF21,LIMK1A,WASF1
    Progesterone-mediated oocyte maturation HSP90AA1.2,MAPK12A,GNAIA,CPEB2,MAPK12B,CDC25B,IGF1RB,MAPK8A,HSP90AA1,ANAPC1

    Protein Function

    ARAF has several biochemical functions, for example, ATP binding,metal ion binding,protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by ARAF itself. We selected most functions ARAF had, and list some proteins which have the same functions with ARAF. You can find most of the proteins on our site.

    Function Related Protein
    protein kinase activity CAMK2G1,NEK2,STK24B,SNRKA,DCLK3,GSK3AA,PRKCBA,EPHA1,STK24A,EPHB4A
    protein serine/threonine kinase activity ADCK1,CAMKK1B,CPNE3,SGK3,STK35L,SRPK1B,CAMK2A,PRKD2,TAOK1,MAPKAPK2
    protein binding NHLH2,ABCD1,APP,KLC3,HDHD3,HES1,FUBP1,PLDN,Tnfrsf22,CEACAM6
    receptor signaling protein activity BAG1,cgr2b,NSMAF,DOK4,RGS12,FLRT3,FLRT1,PLCE1,KLK1B3,KLK1B4
    ATP binding AK3,ATAD3A,BMX,TTBK2,ZAK,MAPKAPK2A,PRKY,TOR1L3,UBA5,NTRK2
    metal ion binding ZNF239,NRXN1A,B3GNT1,CYP2AA4,ZNF74,NUDT15,ZKSCAN3,HIVEP2,ZMYND12,FBP1

    Interacting Protein

    ARAF has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ARAF here. Most of them are supplied by our site. Hope this information will be useful for your research of ARAF.

    MAP2K2;YWHAZ;HSP90AB1;YWHAG

    Resources

    Research Area

    References

    • Sumiyoshi, M; Nakamura, A; et al. Increase in Cellulose Accumulation and Improvement of Saccharification by Overexpression of Arabinofuranosidase in Rice. PLOS ONE 8:-(2013).
    • Yu, L; Yu, CJ; et al. Structural analysis of galactoarabinan from duckweed. CARBOHYDRATE POLYMERS 117:807-812(2015).

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