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ARHGAP19

  • Official Full Name

    Rho GTPase activating protein 19

  • Overview

    Members of the ARHGAP family, such as ARHGAP19, encode negative regulators of Rho GTPases (see RHOA; MIM 165390), which;are involved in cell migration, proliferation, and differentiation, actin remodeling, and G1 cell cycle progression;(Lv et al., 2007 (PubMed 17454002)).
  • Synonyms

    ARHGAP19; Rho GTPase activating protein 19; rho GTPase-activating protein 19; FLJ00194; MGC14258; putative RhoGAP protein; rho-type GTPase-activating protein 19; MGC138804; MGC138805; DKFZp313K217;

  • Cell & Tissue Lysates
  • Recombinant Proteins
  • Protein Pre-coupled Magnetic Beads
  • Chicken
  • Human
  • Rhesus Macaque
  • E.coli
  • HEK293
  • Mammalian Cell
  • His
  • His (Fc)
  • Avi
  • His|SUMO
  • N/A
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human ARHGAP19-8742HCL Recombinant Human ARHGAP19 293 Cell Lysate HEK293 N/A
Human ARHGAP19-1015H Recombinant Human ARHGAP19 Protein (1-494 aa), His-SUMO-tagged E.coli His/SUMO 1-494 aa
Rhesus Macaque ARHGAP19-390R Recombinant Rhesus monkey ARHGAP19 Protein, His-tagged Mammalian Cell His
Rhesus Macaque ARHGAP19-219R Recombinant Rhesus Macaque ARHGAP19 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rhesus Macaque ARHGAP19-219R-B Recombinant Rhesus Macaque ARHGAP19 Protein Pre-coupled Magnetic Beads HEK293
Chicken ARHGAP19-2124C Recombinant Chicken ARHGAP19 Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein

ARHGAP19 involved in several pathways and played different roles in them. We selected most pathways ARHGAP19 participated on our site, such as Rho GTPase cycle, Signal Transduction, Signaling by Rho GTPases, which may be useful for your reference. Also, other proteins which involved in the same pathway with ARHGAP19 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Rho GTPase cycleARHGAP26;ARHGAP25;ARHGAP18;RHOT2;RALBP1;RHOT1B;ARHGEF17;ARHGAP4;ARHGAP44
Signal TransductionOXER1;PMCH;ARAP2;KREMEN1;MYO7A;QRFPR;CBY1;PDK4;ARHGAP28
Signaling by Rho GTPasesARHGAP29B;ARHGAP33;RHOT1B;NOXO1;ARHGAP22;LIN7B;TAGAPB;ARHGAP6;ARHGAP36

ARHGAP19 has several biochemical functions, for example, GTPase activator activity. Some of the functions are cooperated with other proteins, some of the functions could acted by ARHGAP19 itself. We selected most functions ARHGAP19 had, and list some proteins which have the same functions with ARHGAP19. You can find most of the proteins on our site.

Function Related Protein
GTPase activator activityAGAP2;RAP1GAP;RGS4;GIT2B;ARHGAP12;ASAP1A;ERRFI1;ARFGAP1;USP6NL

ARHGAP19 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ARHGAP19 here. Most of them are supplied by our site. Hope this information will be useful for your research of ARHGAP19.

ATXN3

  • Q&As
  • Reviews

Q&As (13)

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Does ARHGAP19 have any known alternative splice variants? 08/17/2022

As of now, there are no known alternative splice variants of ARHGAP19 documented in scientific literature or databases. However, alternate splicing events can give rise to different isoforms with potentially distinct functions in various tissues or developmental stages. Further investigations are required to determine if ARHGAP19 undergoes alternative splicing.

Are there any known interactions or binding partners of ARHGAP19? 05/25/2022

While specific binding partners of ARHGAP19 have not been extensively studied, it is known to interact with RhoA and regulate its activity. ARHGAP19 may also interact with other proteins involved in Rho GTPase signaling pathways, although further research is needed to identify specific binding partners.

Can ARHGAP19 be regulated by any external factors? 04/21/2022

The regulation of ARHGAP19 expression or activity by external factors is currently not well known. However, it is possible that various signaling pathways or stimuli, such as growth factors or extracellular matrix components, may influence ARHGAP19 expression or function. Understanding the regulatory mechanisms that affect ARHGAP19 could provide insights into its role in cellular processes.

Can dysregulation of ARHGAP19 lead to pathological conditions? 01/23/2022

While the specific pathological conditions associated with ARHGAP19 dysregulation are not well defined, alterations in Rho GTPase signaling, which ARHGAP19 modulates, have been implicated in multiple diseases. Dysregulation of RhoA activity, due to abnormal ARHGAP19 function or expression, could potentially contribute to pathological conditions such as cancer, cardiovascular disorders, or neurological disorders. However, extensive investigation is needed to establish a direct link between ARHGAP19 dysregulation and disease pathogenesis.

Are there any known post-translational modifications of ARHGAP19? 09/22/2021

At present, there is limited information on post-translational modifications of ARHGAP19. However, many Rho GAP proteins can undergo phosphorylation or ubiquitination, which can affect their activity or stability. Determining if ARHGAP19 undergoes any post-translational modifications could provide further insights into its regulation and function.

Is ARHGAP19 associated with any diseases? 07/17/2021

Currently, there is limited information on specific diseases associated with ARHGAP19. However, alterations in Rho GTPase signaling pathways, which ARHGAP19 is involved in, have been implicated in various diseases such as cancer, cardiovascular disorders, and neurological conditions. Further research is needed to explore if ARHGAP19 has a direct role in disease development or progression.

Is ARHGAP19 conserved across different species? 03/12/2021

ARHGAP19 shows conservation across various species, including mammals, birds, and reptiles. Its high level of conservation suggests that it plays an important role in fundamental cellular processes. Studying ARHGAP19 in different species can provide valuable insights into its evolutionary significance and functional conservation.

Does ARHGAP19 interact with any other proteins? 05/20/2019

The protein interaction partners of ARHGAP19 have not been extensively characterized. However, as a Rho GTPase-activating protein (Rho GAP), ARHGAP19 is expected to interact with Rho family GTPases, such as RhoA, RhoB, or RhoC, and modulate their activity. Additionally, ARHGAP19 may interact with other signaling proteins or cytoskeletal components to regulate cellular processes. Identifying and characterizing the protein interaction network of ARHGAP19 would provide valuable insights into its functional roles.

Has ARHGAP19 been implicated in cancer or metastasis? 02/09/2019

There is limited information regarding the involvement of ARHGAP19 in cancer or metastasis. However, since Rho GTPase signaling, regulated by ARHGAP19, can influence cancer cell migration and invasion, further investigation is necessary to determine if ARHGAP19 has a role in cancer progression or metastasis.

Is ARHGAP19 a tumor suppressor protein? 08/08/2017

The role of ARHGAP19 as a tumor suppressor protein is currently unclear as there is limited information available. While dysregulated Rho GTPase signaling has been implicated in cancer progression, no direct evidence linking ARHGAP19 to tumor suppression or its involvement in cancer has been reported to date. Further studies are needed to determine if ARHGAP19 functions as a tumor suppressor or if it plays a role in cancer development or progression.

Are there any genetic variants or mutations in ARHGAP19 associated with diseases? 06/03/2017

Currently, there is limited information on genetic variants or mutations specifically associated with ARHGAP19 and diseases. However, considering the importance of Rho GTPase signaling in various diseases, it would be interesting to explore if alterations in ARHGAP19 function or expression contribute to disease susceptibility or progression. Further research is needed in this area.

Is ARHGAP19 implicated in any diseases or disorders? 05/20/2017

Currently, there is limited information about the involvement of ARHGAP19 in specific diseases or disorders. However, dysregulation of Rho GTPase signaling, which ARHGAP19 participates in, has been linked to various pathological conditions. ARHGAP19 dysregulation or mutations could potentially contribute to diseases such as cancer, cardiovascular disorders, or neurological disorders. Further research is needed to establish the precise role of ARHGAP19 in disease pathogenesis.

Is ARHGAP19 involved in any developmental processes? 12/11/2016

While the exact role of ARHGAP19 in development is not well understood, its expression in developing embryos suggests a potential involvement in early developmental processes. Further research is needed to determine the specific contributions of ARHGAP19 in embryogenesis or organogenesis.

Customer Reviews (8)

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Reviews
11/27/2022

    This specificity enables precise quantification and characterization of ARHGAP19 and its interactions with other molecules or proteins of interest.

    11/15/2021

      Its resistance to degradation and denaturation allows for longer storage times and repeated use without compromising its performance or functionality.

      08/05/2021

        Their prompt and insightful responses to inquiries and troubleshooting requests enable me to tackle experimental obstacles with confidence and efficiency.

        05/28/2021

          They understand that each research project may have unique requirements, and they are more than willing to address these specific needs.

          07/13/2019

            When used in Western blotting experiments, the ARHGAP19 protein produces distinct protein bands, allowing for easy visualization and interpretation.

            04/06/2018

              ARHGAP19 protein is known for its stability and robustness, making it suitable for a wide range of experimental conditions.

              08/09/2017

                The manufacturer's commitment to providing excellent technical support is truly impressive.

                06/25/2016

                  Their proactive approach ensures that I am always working with the latest advancements in ARHGAP19 protein research, allowing me to explore new avenues and potentially uncover groundbreaking discoveries.

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