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Official Full Name Rho GTPase activating protein 6
Background This gene encodes a member of the rhoGAP family of proteins which play a role in the regulation of actin polymerization at the plasma membrane during several cellular processes. This protein is thought to have two independent functions, one as a GTPase-activating protein with specificity for RhoA, and another as a cytoskeletal protein that promotes actin remodeling. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene.
Synonyms ARHGAP6; Rho GTPase activating protein 6; rho GTPase-activating protein 6; rhoGAPX 1; ARHGAP 6; Rho type GTPase activating protein RhoGAPX 1; RHOGAP 6; RHOGAP6; RhoGAPX1; OTTHUMP00000022913; OTTHUMP00000022915; OTTHUMP00000022916; OTTHUMP00000022917; OTTHUMP00000022918; OTTHUMP00000236431; rho-type GTPase-activating protein 6; Rho-type GTPase-activating protein RhoGAPX-1; RHOGAPX-1
    • Species :
    • Human
    • Mouse
    • Zebrafish
    • Source :
    • HEK293
    • HEK293T
    • Mammalian Cell
    • Wheat Germ
    • Tag :
    • GST
    • His
    • MYC/DDK
    • Myc
    • DDK
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human ARHGAP6-2704H Recombinant Human ARHGAP6 Protein, MYC/DDK-tagged HEK293 Myc/DDK
    Human ARHGAP6-4452H Recombinant Human ARHGAP6 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
    Human ARHGAP6-772H Recombinant Human ARHGAP6 protein, GST-tagged Wheat Germ GST
    Mouse ARHGAP6-1880M Recombinant Mouse ARHGAP6 Protein Mammalian Cell His
    Mouse Arhgap6-645M Recombinant Mouse Arhgap6 Protein, MYC/DDK-tagged HEK293T MYC/DDK
    Zebrafish ARHGAP6-4011Z Recombinant Zebrafish ARHGAP6 Mammalian Cell His

    ARHGAP6 involved in several pathways and played different roles in them. We selected most pathways ARHGAP6 participated on our site, such as Rho GTPase cycle, Signal Transduction, Signaling by Rho GTPases, which may be useful for your reference. Also, other proteins which involved in the same pathway with ARHGAP6 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Signal Transduction S1PR3; ASH2L; PTPRK; MYO7AA; FGFBP1; RTKN; OXGR1A.3; NEDD8; RHOJ; TJP2B
    Signaling by Rho GTPases ABI1A; RHOU; ARHGAP26; FMNL2; FAM13B1; DEPDC7; ARHGAP17B; ARHGAP4A; ARHGAP12; FGD4

    ARHGAP6 has several biochemical functions, for example, GTPase activator activity, SH3 domain binding, phospholipase activator activity. Some of the functions are cooperated with other proteins, some of the functions could acted by ARHGAP6 itself. We selected most functions ARHGAP6 had, and list some proteins which have the same functions with ARHGAP6. You can find most of the proteins on our site.

    Function Related Protein
    GTPase activator activity ARHGAP36; ARHGAP18; SRGAP3; TSC2; EVI5; GIT2B; BCR; PGAM5; JUN; TBC1D24
    SH3 domain binding LANCL1; CD2AP; KHDRBS2; MYPN; ITM2B; ARHGAP27; ARHGAP31; FMN1; FUT8; ADAM15
    phospholipase activator activity PDPK1; GM2A; CCL5; CCL3; CCL8; ARHGAP6; APOC2
    phospholipase binding PDPK1; CALM1; SERPINB1A; PTPN11; SELE; WAS; CALM; PRKCZ; LMNB1; Pla2r1

    ARHGAP6 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ARHGAP6 here. Most of them are supplied by our site. Hope this information will be useful for your research of ARHGAP6.

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