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Official Full Name Rho guanine nucleotide exchange factor (GEF) 1
Background Rho GTPases play a fundamental role in numerous cellular processes that are initiated by extracellular stimuli that;work through G protein coupled receptors. The encoded protein may form complex with G proteins and stimulate;Rho-dependent signals. Multiple alternatively spliced transcript variants have been found for this gene, but the;full-length nature of some variants has not been defined.
Synonyms ARHGEF1; Rho guanine nucleotide exchange factor (GEF) 1; rho guanine nucleotide exchange factor 1; LBCL2; P115 RHOGEF; SUB1.5; 115 kD protein; 115 kDa guanine nucleotide exchange factor; ARHGEF 1; GEF 1; GEF1; LBCL 2; Lsc homolog; p115RhoGEF; 115-kD protein; LSC; P115-RHOGEF
    • Species :
    • Human
    • Mouse
    • Source :
    • E.coli
    • HEK293
    • HEK293T
    • Mammalian Cell
    • Wheat Germ
    • Tag :
    • GST
    • His
    • MYC/DDK
    • Myc
    • DDK
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human ARHGEF1-2699H Recombinant Human ARHGEF1 Protein, MYC/DDK-tagged HEK293 Myc/DDK
    Human ARHGEF1-27183TH Recombinant Human ARHGEF1, His-tagged E.coli His
    Human ARHGEF1-6362H Recombinant Human ARHGEF1 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
    Human ARHGEF1-777H Recombinant Human ARHGEF1 protein, GST-tagged Wheat Germ GST
    Mouse Arhgef1-1298M Recombinant Mouse Arhgef1 Protein, MYC/DDK-tagged HEK293T MYC/DDK
    Mouse ARHGEF1-1886M Recombinant Mouse ARHGEF1 Protein Mammalian Cell His

    arhgef1 involved in several pathways and played different roles in them. We selected most pathways arhgef1 participated on our site, such as Vascular smooth muscle contraction, Platelet activation, Regulation of actin cytoskeleton, which may be useful for your reference. Also, other proteins which involved in the same pathway with arhgef1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Vascular smooth muscle contraction NPR1A; EDNRAA; MAP2K2B; ARHGEF12; RHOAD; MYL6B; CYP4A10; ADORA2AB; CALM3B; RAF1B
    Platelet activation PRKG1; MYLK3; SYK; PLCB1; FGA; F2RL3; PLCG2; MYLK2; GP1BB; TBXA2R
    Regulation of actin cytoskeleton PTK2AB; ARAF; SCINLB; PPP1R12B; FGF7; RDX; ITGAL; FGFR1; ITGA6B; FGF4
    Pathways in cancer RBX1; FOXO1; IKBKB; ROCK2; RAD51; GNG8; PRKACB; PDGFRA; HIF1A; HSP90AB1
    Proteoglycans in cancer TLR2; PTCH1; IL12B; RAF1; MMP9; PRKCG; RRAS; LUM; PIK3CG; MAPK13

    arhgef1 has several biochemical functions, for example, GTPase activator activity, Rho guanyl-nucleotide exchange factor activity, poly(A) RNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by arhgef1 itself. We selected most functions arhgef1 had, and list some proteins which have the same functions with arhgef1. You can find most of the proteins on our site.

    Function Related Protein
    GTPase activator activity TBC1D7; RANBP1; ADAP2; RGS12B; ARHGDIA; ECT2; SRGAP2B; TBC1D15; RGS14A; ARAP3
    Rho guanyl-nucleotide exchange factor activity FGD3; ARHGEF2; FGD5; PLEKHG7; ARHGEF18; FGD1; FGD2; FGD4; C9orf100; AKAP13
    poly(A) RNA binding RNPS1; SOSTDC1B; IGF2BP1; RBM4B; KPNA2; DDX42; RPS27.1; ERH; CHD2; PAN3
    protein binding PAK2; DLGAP4; POU1F1; TBX1; CDC25C; CCNC; Mill2; AP1G2; KCNH1; CTAG1A

    arhgef1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with arhgef1 here. Most of them are supplied by our site. Hope this information will be useful for your research of arhgef1.

    q7db74_eco57; TCF4; GNA13; q81y32_bacan; CSNK1E; RHOB; SREBF2; mhpD1; iolA2; pi3p

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