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ARHGEF3

  • Official Full Name

    Rho guanine nucleotide exchange factor (GEF) 3

  • Overview

    Rho-like GTPases are involved in a variety of cellular processes, and they are activated by binding GTP and inactivated by conversion of GTP to GDP by their intrinsic GTPase activity. Guanine nucleotide exchange factors (GEFs) accelerate the GTPase activity of Rho GTPases by catalyzing their release of bound GDP. This gene encodes a guanine nucleotide exchange factor, which specifically activates two members of the Rho GTPase family: RHOA and RHOB, both of which have a role in bone cell biology. It has been identified that genetic variation in this gene plays a role in the determination of bone mineral density (BMD), indicating the implication of this gene in postmenopausal osteoporosis. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
  • Synonyms

    ARHGEF3; Rho guanine nucleotide exchange factor (GEF) 3; rho guanine nucleotide exchange factor 3; DKFZP434F2429; exchange factor found in platelets and leukemic and neuronal tissues; XPLN; GEF3; RhoGEF protein; STA3; 59.8 kDA protein; ARHGEF 3; Exchange factor found in platelets and leukemic and neuronal tissues XPLN; FLJ98126; GEF 3; MGC118905; STA 3; exchange factor found in platelets and leukemic and neuronal tissues, XPLN;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Chicken
  • Human
  • Mouse
  • Zebrafish
  • HEK293
  • In Vitro Cell Free System
  • Mammalian Cell
  • Wheat Germ
  • GST
  • His
  • His (Fc)
  • Avi
  • N/A
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human ARHGEF3-786H Recombinant Human ARHGEF3 protein, GST-tagged Wheat Germ GST
Human ARHGEF3-8731HCL Recombinant Human ARHGEF3 293 Cell Lysate HEK293 N/A
Human ARHGEF3-1238HF Recombinant Full Length Human ARHGEF3 Protein, GST-tagged In Vitro Cell Free System GST 324 amino acids
Mouse ARHGEF3-1898M Recombinant Mouse ARHGEF3 Protein Mammalian Cell His
Mouse ARHGEF3-697M Recombinant Mouse ARHGEF3 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse ARHGEF3-697M-B Recombinant Mouse ARHGEF3 Protein Pre-coupled Magnetic Beads HEK293
Zebrafish ARHGEF3-5258Z Recombinant Zebrafish ARHGEF3 Mammalian Cell His
Chicken ARHGEF3-2308C Recombinant Chicken ARHGEF3 Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein

ARHGEF3 involved in several pathways and played different roles in them. We selected most pathways ARHGEF3 participated on our site, such as Cell death signalling via NRAGE, NRIF and NADE, G alpha (12/13) signalling events, GPCR downstream signaling, which may be useful for your reference. Also, other proteins which involved in the same pathway with ARHGEF3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Cell death signalling via NRAGE, NRIF and NADEITSN1;FGD4;FGD4A;TRIO;ARHGAP4A;ARHGEF18A;ECT2;FGD2;NET1
G alpha (12/13) signalling eventsRHOC;GNA13B;DCLRE1B;ADRA1D;ARHGEF18;ARHGEF9;ECT2;NET1;ARHGEF18A
GPCR downstream signalingARHGEF17;CXCL13;ARHGEF18A;GPR17;TAS2R7;GPR65;FPR-RS6;ARHGEF25;OXER1
NRAGE signals death through JNKARHGAP4;AKAP13;ECT2;ARHGAP4A;NET1;DCLRE1B;ARHGEF17;PLEKHG2;ARHGEF18A
Regulation of RhoA activityABR;FARP1;DLC1;ARHGAP9;DEF6;OBSCN;PLEKHG6;ARHGEF10L;ECT2
Rho GTPase cycleCHN2;MCF2L;RALBP1;ARHGAP10;PLEKHG2;TAGAP;DLC1;ARAP1;CHN1
Signal TransductionASH2L;RDH13;TRH;TAC2;TAGAP1;ARHGAP33;RGS18;ARAP1;ARHGAP15
Signaling by GPCRARHGEF16;ARHGEF17;PNOC;HCAR1-2;CD97;OPN4B;EMR1;RGS7;PROK1

ARHGEF3 has several biochemical functions, for example, Rho guanyl-nucleotide exchange factor activity, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by ARHGEF3 itself. We selected most functions ARHGEF3 had, and list some proteins which have the same functions with ARHGEF3. You can find most of the proteins on our site.

Function Related Protein
Rho guanyl-nucleotide exchange factor activityPLEKHG7;ARHGEF10;MCF2L;ARHGEF37;OBSCN;ARHGEF7;PLEKHG6;ARHGEF33;ARHGEF25
protein bindingNKX2;TP53INP1;CXCR7;P2RX4;Car8;AGL;EFNB2;ERCC5;RAD21

ARHGEF3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ARHGEF3 here. Most of them are supplied by our site. Hope this information will be useful for your research of ARHGEF3.

TRIM27; TRIM23; CEP70

  • Q&As
  • Reviews

Q&As (17)

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How does ARHGEF3 influence the actin cytoskeleton? 08/19/2022

ARHGEF3 activates Rho GTPases, particularly RhoA, which are key regulators of actin cytoskeletal dynamics. Activation of RhoA by ARHGEF3 leads to the formation of stress fibers and focal adhesions, which are important for cell migration and adhesion. ARHGEF3 also regulates the organization of actin filaments in dendritic spines, contributing to synaptic plasticity and neuronal development.

Can ARHGEF3 interact with membrane lipids? 05/03/2022

Yes, ARHGEF3 contains a Sec14-PH domain, which enables its interaction with membrane lipids, particularly phosphoinositides. This interaction is crucial for the recruitment of ARHGEF3 to specific cellular membranes, where it can activate Rho GTPases and modulate actin cytoskeletal dynamics.

Can ARHGEF3 interact with other proteins or signaling pathways? 01/30/2022

Yes, ARHGEF3 can interact with several proteins and signaling pathways to regulate various cellular processes. For example, it interacts with PAK1 and LIM kinase (LIMK), which are downstream effectors of Rho GTPases involved in actin cytoskeletal regulation. ARHGEF3 also interacts with PDZ domain-containing proteins, such as SAP102, to modulate synaptic function.

Can ARHGEF3 be a potential therapeutic target for neurodevelopmental disorders? 12/17/2021

As ARHGEF3 dysregulation has been associated with neurodevelopmental disorders like autism spectrum disorders and schizophrenia, it holds promise as a potential therapeutic target. However, further studies are needed to fully understand its involvement in these conditions and to explore potential therapeutic strategies.

Does ARHGEF3 have any post-translational modifications? 09/06/2021

Yes, ARHGEF3 can undergo various post-translational modifications, including phosphorylation, ubiquitination, and sumoylation. These modifications regulate the activity, stability, and localization of ARHGEF3 within the cell.

How is ARHGEF3 involved in neural development? 07/24/2021

ARHGEF3 is crucial for neuronal migration, axon guidance, dendritic spine formation, and synaptic maturation. It influences the structural remodeling of neurons and contributes to the establishment and maintenance of proper neural connectivity.

Does ARHGEF3 have any role in immune responses? 05/31/2021

ARHGEF3 has been implicated in immune responses, particularly in the regulation of immune cell migration and adhesion. It influences the activation and migration of T cells, which are crucial for immune responses. ARHGEF3 also interacts with signaling molecules in immune cells, such as lymphocyte-specific protein tyrosine kinase (Lck), to modulate immune cell function.

Are there any other functions or interactions of ARHGEF3? 03/30/2021

ARHGEF3 has been implicated in immune responses, cardiovascular development, and cancer progression. Additionally, it interacts with various proteins, including NMDA receptors, kinases, and cytoskeletal elements, to modulate cellular processes and signaling pathways.

Are there any animal models with ARHGEF3 deletion or mutations? 12/20/2020

Yes, genetically modified animal models, such as mice, with ARHGEF3 deletions or mutations have been generated to study the role of ARHGEF3 in various physiological and pathological processes. These models provide valuable insights into the function and importance of ARHGEF3 in vivo.

What are the potential roles of ARHGEF3 in neurological disorders? 06/25/2020

Dysregulation or mutations in ARHGEF3 have been associated with several neurological and psychiatric disorders, including schizophrenia, Alzheimer's disease, bipolar disorder, and autism spectrum disorders. These findings suggest that ARHGEF3 dysfunction could contribute to the underlying mechanisms of these conditions.

How is ARHGEF3 involved in synaptic plasticity? 01/03/2020

ARHGEF3 plays a critical role in synaptic plasticity, which refers to the ability of synapses to change their strength and structure. It influences the development and maturation of dendritic spines, which are small protrusions on neurons where synapses form. By modulating cytoskeletal dynamics and signaling pathways, ARHGEF3 contributes to synaptic remodeling necessary for learning and memory processes.

Is ARHGEF3 expressed in all tissues? 04/23/2019

ARHGEF3 is widely expressed in various tissues throughout the body, although its expression levels may vary in different cell types. It is highly expressed in the brain, where it plays a critical role in synaptic plasticity and neuronal development. ARHGEF3 is also expressed in other tissues, including the heart, liver, kidney, and immune cells.

Is ARHGEF3 involved in neuronal development? 12/15/2018

Yes, ARHGEF3 plays a critical role in neuronal development by regulating dendritic spine morphology and synapse formation. It contributes to the maturation of dendritic spines, which are essential for synaptic connectivity and the proper functioning of neuronal circuits. ARHGEF3 also participates in neuronal migration during brain development.

Can ARHGEF3 be targeted for therapeutic interventions? 04/19/2018

While there are currently no specific drugs targeting ARHGEF3, since its dysregulation has been implicated in neurological disorders, further understanding of its mechanisms and interactions may pave the way for potential therapeutic interventions in the future.

Can ARHGEF3 be regulated by microRNAs? 03/07/2017

Yes, ARHGEF3 expression can be regulated by microRNAs (miRNAs), which are small non-coding RNA molecules that bind to the messenger RNA (mRNA) of target genes, leading to their degradation or translational repression. Several miRNAs, such as miR-34a and miR-124, have been reported to target ARHGEF3 and regulate its expression levels.

Are there any drugs or therapies targeting ARHGEF3? 01/27/2017

Currently, there are no specific drugs or therapies targeting ARHGEF3. However, further research on understanding its role in different diseases may lead to the development of targeted therapies in the future.

How is ARHGEF3 involved in cancer progression? 06/20/2016

ARHGEF3 has been implicated in cancer progression, particularly in metastasis and invasion. It activates Rho GTPases, which are involved in cell migration and cytoskeletal rearrangement, processes crucial for cancer cell invasion. Moreover, ARHGEF3 interacts with other signaling molecules and pathways that contribute to cancer progression.

Customer Reviews (8)

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Reviews
04/09/2022

    Their team of experts possesses an in-depth understanding of the protein and its applications, which proves instrumental in troubleshooting and optimizing experimental protocols.

    01/08/2021

      the manufacturer's dedication to innovation and continuous improvement stands out.

      04/26/2020

        They continuously stay up-to-date with the latest scientific advancements and customer feedback, allowing them to refine the ARHGEF3 protein based on emerging trends.

        07/08/2019

          the exemplary technical support provided by the manufacturer adds immense value to my experience.

          09/24/2018

            They provide comprehensive assistance, ensuring that any queries or concerns I have regarding the ARHGEF3 protein are promptly addressed.

            03/15/2018

              If needed, the availability of bulk purchase options further optimizes resource allocation, enabling me to conduct extensive experiments without compromising on quality.

              01/14/2018

                I am confident that their expertise and prompt assistance can help resolve any challenges I may encounter along the way.

                05/25/2016

                  Whether it's troubleshooting experimental hurdles or optimizing protocols, their dedicated team is there to guide me, ensuring smooth progress and successful outcomes.

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