ARHGEF3
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Official Full Name
Rho guanine nucleotide exchange factor (GEF) 3
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Overview
Rho-like GTPases are involved in a variety of cellular processes, and they are activated by binding GTP and inactivated by conversion of GTP to GDP by their intrinsic GTPase activity. Guanine nucleotide exchange factors (GEFs) accelerate the GTPase activity of Rho GTPases by catalyzing their release of bound GDP. This gene encodes a guanine nucleotide exchange factor, which specifically activates two members of the Rho GTPase family: RHOA and RHOB, both of which have a role in bone cell biology. It has been identified that genetic variation in this gene plays a role in the determination of bone mineral density (BMD), indicating the implication of this gene in postmenopausal osteoporosis. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. -
Synonyms
ARHGEF3; Rho guanine nucleotide exchange factor (GEF) 3; rho guanine nucleotide exchange factor 3; DKFZP434F2429; exchange factor found in platelets and leukemic and neuronal tissues; XPLN; GEF3; RhoGEF protein; STA3; 59.8 kDA protein; ARHGEF 3; Exchange factor found in platelets and leukemic and neuronal tissues XPLN; FLJ98126; GEF 3; MGC118905; STA 3; exchange factor found in platelets and leukemic and neuronal tissues, XPLN;
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Chicken
- Human
- Mouse
- Zebrafish
- HEK293
- In Vitro Cell Free System
- Mammalian Cell
- Wheat Germ
- GST
- His
- His (Fc)
- Avi
- N/A
Species | Cat.# | Product name | Source (Host) | Tag | Protein Length | Price |
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Human | ARHGEF3-786H | Recombinant Human ARHGEF3 protein, GST-tagged | Wheat Germ | GST | ||
Human | ARHGEF3-8731HCL | Recombinant Human ARHGEF3 293 Cell Lysate | HEK293 | N/A | ||
Human | ARHGEF3-1238HF | Recombinant Full Length Human ARHGEF3 Protein, GST-tagged | In Vitro Cell Free System | GST | 324 amino acids | |
Mouse | ARHGEF3-1898M | Recombinant Mouse ARHGEF3 Protein | Mammalian Cell | His | ||
Mouse | ARHGEF3-697M | Recombinant Mouse ARHGEF3 Protein, His (Fc)-Avi-tagged | HEK293 | His (Fc)-Avi | ||
Mouse | ARHGEF3-697M-B | Recombinant Mouse ARHGEF3 Protein Pre-coupled Magnetic Beads | HEK293 | |||
Zebrafish | ARHGEF3-5258Z | Recombinant Zebrafish ARHGEF3 | Mammalian Cell | His | ||
Chicken | ARHGEF3-2308C | Recombinant Chicken ARHGEF3 | Mammalian Cell | His |
- Involved Pathway
- Protein Function
- Interacting Protein
ARHGEF3 involved in several pathways and played different roles in them. We selected most pathways ARHGEF3 participated on our site, such as Cell death signalling via NRAGE, NRIF and NADE, G alpha (12/13) signalling events, GPCR downstream signaling, which may be useful for your reference. Also, other proteins which involved in the same pathway with ARHGEF3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name | Pathway Related Protein |
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Cell death signalling via NRAGE, NRIF and NADE | ITSN1;FGD4;FGD4A;TRIO;ARHGAP4A;ARHGEF18A;ECT2;FGD2;NET1 |
G alpha (12/13) signalling events | RHOC;GNA13B;DCLRE1B;ADRA1D;ARHGEF18;ARHGEF9;ECT2;NET1;ARHGEF18A |
GPCR downstream signaling | ARHGEF17;CXCL13;ARHGEF18A;GPR17;TAS2R7;GPR65;FPR-RS6;ARHGEF25;OXER1 |
NRAGE signals death through JNK | ARHGAP4;AKAP13;ECT2;ARHGAP4A;NET1;DCLRE1B;ARHGEF17;PLEKHG2;ARHGEF18A |
Regulation of RhoA activity | ABR;FARP1;DLC1;ARHGAP9;DEF6;OBSCN;PLEKHG6;ARHGEF10L;ECT2 |
Rho GTPase cycle | CHN2;MCF2L;RALBP1;ARHGAP10;PLEKHG2;TAGAP;DLC1;ARAP1;CHN1 |
Signal Transduction | ASH2L;RDH13;TRH;TAC2;TAGAP1;ARHGAP33;RGS18;ARAP1;ARHGAP15 |
Signaling by GPCR | ARHGEF16;ARHGEF17;PNOC;HCAR1-2;CD97;OPN4B;EMR1;RGS7;PROK1 |
ARHGEF3 has several biochemical functions, for example, Rho guanyl-nucleotide exchange factor activity, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by ARHGEF3 itself. We selected most functions ARHGEF3 had, and list some proteins which have the same functions with ARHGEF3. You can find most of the proteins on our site.
Function | Related Protein |
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Rho guanyl-nucleotide exchange factor activity | PLEKHG7;ARHGEF10;MCF2L;ARHGEF37;OBSCN;ARHGEF7;PLEKHG6;ARHGEF33;ARHGEF25 |
protein binding | NKX2;TP53INP1;CXCR7;P2RX4;Car8;AGL;EFNB2;ERCC5;RAD21 |
ARHGEF3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ARHGEF3 here. Most of them are supplied by our site. Hope this information will be useful for your research of ARHGEF3.
TRIM27; TRIM23; CEP70
- Q&As
- Reviews
Q&As (17)
Ask a questionARHGEF3 activates Rho GTPases, particularly RhoA, which are key regulators of actin cytoskeletal dynamics. Activation of RhoA by ARHGEF3 leads to the formation of stress fibers and focal adhesions, which are important for cell migration and adhesion. ARHGEF3 also regulates the organization of actin filaments in dendritic spines, contributing to synaptic plasticity and neuronal development.
Yes, ARHGEF3 contains a Sec14-PH domain, which enables its interaction with membrane lipids, particularly phosphoinositides. This interaction is crucial for the recruitment of ARHGEF3 to specific cellular membranes, where it can activate Rho GTPases and modulate actin cytoskeletal dynamics.
Yes, ARHGEF3 can interact with several proteins and signaling pathways to regulate various cellular processes. For example, it interacts with PAK1 and LIM kinase (LIMK), which are downstream effectors of Rho GTPases involved in actin cytoskeletal regulation. ARHGEF3 also interacts with PDZ domain-containing proteins, such as SAP102, to modulate synaptic function.
As ARHGEF3 dysregulation has been associated with neurodevelopmental disorders like autism spectrum disorders and schizophrenia, it holds promise as a potential therapeutic target. However, further studies are needed to fully understand its involvement in these conditions and to explore potential therapeutic strategies.
Yes, ARHGEF3 can undergo various post-translational modifications, including phosphorylation, ubiquitination, and sumoylation. These modifications regulate the activity, stability, and localization of ARHGEF3 within the cell.
ARHGEF3 is crucial for neuronal migration, axon guidance, dendritic spine formation, and synaptic maturation. It influences the structural remodeling of neurons and contributes to the establishment and maintenance of proper neural connectivity.
ARHGEF3 has been implicated in immune responses, particularly in the regulation of immune cell migration and adhesion. It influences the activation and migration of T cells, which are crucial for immune responses. ARHGEF3 also interacts with signaling molecules in immune cells, such as lymphocyte-specific protein tyrosine kinase (Lck), to modulate immune cell function.
ARHGEF3 has been implicated in immune responses, cardiovascular development, and cancer progression. Additionally, it interacts with various proteins, including NMDA receptors, kinases, and cytoskeletal elements, to modulate cellular processes and signaling pathways.
Yes, genetically modified animal models, such as mice, with ARHGEF3 deletions or mutations have been generated to study the role of ARHGEF3 in various physiological and pathological processes. These models provide valuable insights into the function and importance of ARHGEF3 in vivo.
Dysregulation or mutations in ARHGEF3 have been associated with several neurological and psychiatric disorders, including schizophrenia, Alzheimer's disease, bipolar disorder, and autism spectrum disorders. These findings suggest that ARHGEF3 dysfunction could contribute to the underlying mechanisms of these conditions.
ARHGEF3 plays a critical role in synaptic plasticity, which refers to the ability of synapses to change their strength and structure. It influences the development and maturation of dendritic spines, which are small protrusions on neurons where synapses form. By modulating cytoskeletal dynamics and signaling pathways, ARHGEF3 contributes to synaptic remodeling necessary for learning and memory processes.
ARHGEF3 is widely expressed in various tissues throughout the body, although its expression levels may vary in different cell types. It is highly expressed in the brain, where it plays a critical role in synaptic plasticity and neuronal development. ARHGEF3 is also expressed in other tissues, including the heart, liver, kidney, and immune cells.
Yes, ARHGEF3 plays a critical role in neuronal development by regulating dendritic spine morphology and synapse formation. It contributes to the maturation of dendritic spines, which are essential for synaptic connectivity and the proper functioning of neuronal circuits. ARHGEF3 also participates in neuronal migration during brain development.
While there are currently no specific drugs targeting ARHGEF3, since its dysregulation has been implicated in neurological disorders, further understanding of its mechanisms and interactions may pave the way for potential therapeutic interventions in the future.
Yes, ARHGEF3 expression can be regulated by microRNAs (miRNAs), which are small non-coding RNA molecules that bind to the messenger RNA (mRNA) of target genes, leading to their degradation or translational repression. Several miRNAs, such as miR-34a and miR-124, have been reported to target ARHGEF3 and regulate its expression levels.
Currently, there are no specific drugs or therapies targeting ARHGEF3. However, further research on understanding its role in different diseases may lead to the development of targeted therapies in the future.
ARHGEF3 has been implicated in cancer progression, particularly in metastasis and invasion. It activates Rho GTPases, which are involved in cell migration and cytoskeletal rearrangement, processes crucial for cancer cell invasion. Moreover, ARHGEF3 interacts with other signaling molecules and pathways that contribute to cancer progression.
Customer Reviews (8)
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