ARID4A

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ARID4A

Official Full Name AT rich interactive domain 4A (RBP1-like)
Background The protein encoded by this gene is a ubiquitously expressed nuclear protein. It binds directly, with several other proteins, to retinoblastoma protein (pRB) which regulates cell proliferation. pRB represses transcription by recruiting the encoded protein. This protein, in turn, serves as a bridging molecule to recruit HDACs and, in addition, provides a second HDAC-independent repression function. The encoded protein possesses transcriptional repression activity. Multiple alternatively spliced transcripts have been observed for this gene, although not all transcript variants have been fully described.
Synonyms ARID4A; AT rich interactive domain 4A (RBP1-like); RBBP1, retinoblastoma binding protein 1; AT-rich interactive domain-containing protein 4A; RBP 1; RBP1; AT rich interactive domain containing protein 4A; ARID 4A; ARID domain containing protein 4A; AT rich interactive domain 4A; RBBP 1; RBBP1; RBP1 like; OTTHUMP00000179023; OTTHUMP00000179024; OTTHUMP00000197517; retinoblastoma binding protein 1; retinoblastoma-binding protein 1; ARID domain-containing protein 4A; RBP-1; RBBP-1
    • Species :
    • Chicken
    • Human
    • Zebrafish
    • Source :
    • E.Coli or Yeast
    • Mammalian Cell
    • Wheat Germ
    • Tag :
    • GST
    • His
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human ARID4A-3680H Recombinant Human ARID4A, His-tagged E.Coli or Yeast His
    Human ARID4A-797H Recombinant Human ARID4A protein, GST-tagged Wheat Germ GST
    Chicken ARID4A-2117C Recombinant Chicken ARID4A Mammalian Cell His
    Zebrafish ARID4A-3363Z Recombinant Zebrafish ARID4A Mammalian Cell His

    ARID4A involved in several pathways and played different roles in them. We selected most pathways ARID4A participated on our site, such as Chromatin modifying enzymes, Chromatin organization, HDACs deacetylate histones, which may be useful for your reference. Also, other proteins which involved in the same pathway with ARID4A were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Chromatin modifying enzymes MCRS1; KDM5D; SMARCC2; RBBP4; PHF20B; TADA3; SMYD3; MBIP; ING4; PBRM1
    Chromatin organization CHD4A; KAT7; MBD3; PBRM1L; C17orf81; SMARCA4; KAT6A; TAF6L; PADI6; KIAA1267
    HDACs deacetylate histones SAP30L; MTA1; MTA2; KDM1A; HMG20B; SAP30; GATAD2B; PHF21A; SAP18; ARID4A

    ARID4A has several biochemical functions, for example, DNA binding, transcription factor activity, sequence-specific DNA binding, transcription regulatory region DNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by ARID4A itself. We selected most functions ARID4A had, and list some proteins which have the same functions with ARID4A. You can find most of the proteins on our site.

    Function Related Protein
    DNA binding GATA1; RCOR1; IER2; H2BFWT; PARP4; ZNF385A; HOXC9A; POLE; DNASE1L1; NTNG1
    transcription factor activity, sequence-specific DNA binding HMGA1A; STAT5A; ELK3; BLF; RXRGB; IKZF2; MEF2A; MSC; POU3F1; NR1D4B
    transcription regulatory region DNA binding KLF4; STAT3; RBBP5; CTNNB1; CCNT1; REST; NFKB1; SFPQ; HMGB2; ZFP746

    ARID4A has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ARID4A here. Most of them are supplied by our site. Hope this information will be useful for your research of ARID4A.

    DEDD; BRMS1; q9rn24_bacan; SAP30; HDAC1

    Fouz, N; Amid, A; et al. Gene Expression Analysis in MCF-7 Breast Cancer Cells Treated with Recombinant Bromelain. APPLIED BIOCHEMISTRY AND BIOTECHNOLOGY 173:1618-1639(2014).
    Cajuso, T; Hanninen, UA; et al. Exome sequencing reveals frequent inactivating mutations in ARID1A, ARID1B, ARID2 and ARID4A in microsatellite unstable colorectal cancer. INTERNATIONAL JOURNAL OF CANCER 135:611-623(2014).

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