ARIH2
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Official Full Name
ariadne homolog 2
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Overview
Protein ariadne-2 homolog is a protein that in humans is encoded by the ARIH2 gene. -
Synonyms
ARIH2; ariadne homolog 2 (Drosophila); ariadne (Drosophila) homolog 2; E3 ubiquitin-protein ligase ARIH2; all trans retinoic acid inducible RING finger; TRIAD1; ARI-2; protein ariadne-2 homolog; all-trans retinoic acid inducible RING finger; ARI2; FLJ1093;
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Chicken
- Human
- Mouse
- Zebrafish
- E.coli
- HEK293
- HEK293T
- In Vitro Cell Free System
- Mammalian Cell
- Mammalian cells
- Wheat Germ
- Flag
- GST
- His
- His (Fc)
- Avi
- Myc
- DDK
- N/A
| Species | Cat.# | Product name | Source (Host) | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| Human | ARIH2-800H | Recombinant Human ARIH2 protein, GST-tagged | Wheat Germ | GST |
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| Human | ARIH2-8725HCL | Recombinant Human ARIH2 293 Cell Lysate | HEK293 | N/A |
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| Human | ARIH2-1121HF | Recombinant Full Length Human ARIH2 Protein, GST-tagged | In Vitro Cell Free System | GST | 493 amino acids |
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| Human | ARIH2-3441H | Recombinant Human ARIH2 protein, His-tagged | E.coli | His | 140-493 aa | |
| Human | ARIH2-377H | Recombinant Human ARIH2 Protein, His (Fc)-Avi-tagged | HEK293 | His (Fc)-Avi |
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| Human | ARIH2-1192HFL | Recombinant Full Length Human ARIH2 Protein, C-Flag-tagged | Mammalian cells | Flag |
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| Human | ARIH2-377H-B | Recombinant Human ARIH2 Protein Pre-coupled Magnetic Beads | HEK293 |
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| Mouse | Arih2-1700M | Recombinant Mouse Arih2 Protein, Myc/DDK-tagged | HEK293T | Myc/DDK |
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| Zebrafish | ARIH2-12359Z | Recombinant Zebrafish ARIH2 | Mammalian Cell | His |
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| Chicken | ARIH2-4250C | Recombinant Chicken ARIH2 | Mammalian Cell | His |
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- Involved Pathway
- Protein Function
- Interacting Protein
ARIH2 involved in several pathways and played different roles in them. We selected most pathways ARIH2 participated on our site, such as Adaptive Immune System, Antigen processing: Ubiquitination &, Proteasome degradation, which may be useful for your reference. Also, other proteins which involved in the same pathway with ARIH2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Adaptive Immune System | AGO2;PJA2;RAP1GAP2;RBCK1;LRR1;SPSB1;CDKN1B;PPIAL4A;AKT3 |
| Antigen processing: Ubiquitination & | ASB6;ASB3;WSB1;RNF41;TRIM11;ATG7;UBE2E3;RNF220;VPRBP |
| Proteasome degradation | UBE2J2;UBR1;RNF6;RNF123;MKRN1;ASB9;RNF14;RNF41;HECTD3 |
| Class I MHC mediated antigen processing & | GAN;WSB1;ARIH2;TRIM39;RNF25;SEC23A;TRIM11;ASB8;ASB10 |
| presentation | LRSAM1;CYBB;SH3RF1;WWP1;RNF138;SEC24A;ASB13;CMTM2A;KLHL20 |
| Immune System | KPNA4;TRIM48;DEFA3;GZMM;TREM1;CRCP;DEFB106A;LY86;PANX1B |
ARIH2 has several biochemical functions, for example, ligase activity, nucleic acid binding, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by ARIH2 itself. We selected most functions ARIH2 had, and list some proteins which have the same functions with ARIH2. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| ligase activity | MARCH3;UBE2L3A;TRAIP;IRF2BP1;UBE4B;PIAS3;CBLC;RNF170;UBE2KB |
| nucleic acid binding | KHSRP;ZCCHC10;RBM4.3;PRDM7;ZNF644A;N6AMT2;PNLDC1;ZFP385C;PABPC1A |
| protein binding | FFAR2;MCM5;CDKN1B;LINC00482;COL13A1;FAM60A;GTPBP4;SDPR;PPP4R1 |
| ubiquitin conjugating enzyme binding | RNF144B;RNF144AB;DCUN1D2B;ZMYM2;RNF144AA;RNF144A;RNF180;RASD2;DCUN1D4 |
| ubiquitin protein ligase activity | TRIM6;RNF144AA;RNF149;SIAH2L;UBE2G2;UBE2O;UBE2R2;RNF111;MSL2 |
| ubiquitin-protein transferase activity | UBE2G2;MUL1B;RNF115;RNF38;UBE2W;FBXO9;BRCA1;FBXL14B;MGRN1 |
| zinc ion binding | PGR;TRIM48;DHX58;MARCH4;MARCH7;MIB2;PDLIM7;TRIM35-35;NANOS2 |
ARIH2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ARIH2 here. Most of them are supplied by our site. Hope this information will be useful for your research of ARIH2.
UBE2L3; UBE2L6; TP53
- Q&As
- Reviews
Q&As (11)
Ask a questionYes, ARIH2 has been implicated in cancer development and progression. Its dysregulation has been observed in several cancer types, and studies have shown its role in regulating the stability and activity of oncoproteins and tumor suppressors.
ARIH2 has been shown to ubiquitinate various proteins, including NEDD8-conjugating enzyme UbcH7, p53, and the EphA2 receptor, among others.
Yes, ARIH2 interacts with various proteins, including the NEDD8-conjugating enzyme UbcH7, p53, and multiple components of the immune response pathway.
Research has suggested that ARIH2 may be involved in the pathogenesis of certain diseases, including cancer and neurodegenerative disorders.
ARIH2 functions as an E3 ubiquitin ligase by binding to the target protein and facilitating the transfer of ubiquitin from the E2 ubiquitin-conjugating enzyme to the target protein.
Yes, ARIH2 has been implicated in the regulation of immune responses. It is involved in the degradation of immune signaling proteins, such as IKKγ and TRAF3, thereby modulating the activation of immune pathways.
Future research on ARIH2 aims to further elucidate its molecular mechanisms, identify additional substrates, explore its potential as a therapeutic target, and understand its role in various diseases.
Researchers employ techniques such as gene expression analysis, protein-protein interaction studies, structural biology, and molecular genetics to investigate the ARIH2 protein.
Ubiquitination by ARIH2 can lead to proteasomal degradation of the target protein, resulting in regulation of cellular processes, such as cell cycle progression, DNA repair, and immune responses.
Currently, there are no specific inhibitors or activators known for ARIH2. However, research efforts are underway to identify small molecules or compounds that can modulate its activity for potential therapeutic purposes.
Targeting ARIH2 has shown potential for therapeutic intervention, particularly in the fields of cancer treatment and neurodegenerative disease research. However, further studies are needed to fully understand its potential as a therapeutic target.
Customer Reviews (10)
Write a reviewThis flexibility ensures that the ARIH2 protein can address my specific research objectives efficiently.
Their experienced team is dedicated to resolving any issues or challenges I may encounter during my experiments, providing prompt and effective solutions.
the manufacturer's technical expertise can be advantageous to researchers.
Its purity, stability, and consistency ensure reliable and reproducible results, giving me confidence in the integrity of my research findings.
This versatility enables researchers to explore ARIH2's function and role in a range of biological processes, making it a valuable tool across diverse research fields.
With their assistance, I can overcome obstacles and optimize my experimental setup.
With the ARIH2 protein and the manufacturer's support, I am confident in obtaining accurate and meaningful results for my scientific investigations.
In addition to the advantages of ARIH2 protein itself, the manufacturer can play a crucial role in supporting the research efforts.
This quality control is essential for obtaining reliable and reproducible data, as any variability in protein quality can introduce confounding factors into experiments.
They can offer guidance on experimental design, protocol optimization, and troubleshooting, helping researchers overcome any challenges encountered during their trials.
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