ARL11
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Official Full Name
ADP-ribosylation factor-like 11
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Overview
This gene encodes a tumor suppressor related to the ADP-ribosylation factor (ARF) family of proteins. The encoded protein may play a role in apoptosis in a caspase-dependent manner. Polymorphisms in this gene have been associated with some familial cancers. -
Synonyms
ARL11; ADP-ribosylation factor-like 11; ADP-ribosylation factor-like protein 11; ARLTS1; FLJ33930; ADP ribosylation factor like 11; ADP ribosylation factor like protein 11; ADP ribosylation factor like tumor suppressor protein 1; ADP-ribosylation factor-like tumor suppressor protein 1; ARL11_HUMAN;
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Human
- Mouse
- Rat
- Rhesus Macaque
- Zebrafish
- E.coli
- HEK293
- HEK293T
- In Vitro Cell Free System
- Mammalian Cell
- Wheat Germ
- GST
- His
- His (Fc)
- Avi
- Myc
- DDK
- N/A
- Involved Pathway
- Protein Function
- Interacting Protein
- ARL11 Related Articles
ARL11 involved in several pathways and played different roles in them. We selected most pathways ARL11 participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with ARL11 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|
ARL11 has several biochemical functions, for example, GTP binding, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by ARL11 itself. We selected most functions ARL11 had, and list some proteins which have the same functions with ARL11. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| GTP binding | IIGP1;NUDT16;GMPPAA;MX2;RAC2;SRP54A;RAB43;NPR1;RAB17 |
| protein binding | FAM113A;ETS1;ZEB1;PRCC;MTPAP;DNAJA4;COPG;PTGER4;MAGEB6 |
ARL11 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ARL11 here. Most of them are supplied by our site. Hope this information will be useful for your research of ARL11.
TRIP13
- Q&As
- Reviews
Q&As (8)
Ask a questionLimited information is available regarding post-translational modifications (PTMs) of Arl11. However, like other GTPases, Arl11 may undergo PTMs such as phosphorylation, acetylation, or lipidation. These modifications can potentially regulate its activity, localization, and binding partners.
Arl11 is evolutionarily conserved among various species, including mammals, birds, reptiles, and amphibians. Its conservation suggests a functional importance, although the extent of its conservation and specific roles may differ across different organisms.
Limited studies have been conducted on the expression pattern of Arl11. However, available data suggests that Arl11 is expressed in various tissues and cells, although the specific levels and localization may vary.
Currently, there is limited information available regarding the involvement of Arl11 in cancer. However, recent studies have suggested potential associations between altered expression of Arl11 and certain types of cancer, indicating a possible role in tumor biology. Further investigations are needed to determine its precise contribution to cancer development and progression.
To date, there are no known animal models specifically targeting Arl11. Developing animal models, such as knockout or transgenic mice, could provide valuable insights into the physiological functions of Arl11 and its potential implications in human health and disease.
As of now, there are no known drugs or specific inhibitors developed to directly target Arl11. The lack of comprehensive studies on Arl11's involvement in diseases has limited the development of therapeutic interventions. Identification of small molecule modulators or inhibitors may require further research.
The binding partners or interactors of Arl11 have not been extensively characterized. Further research is needed to identify potential protein partners that interact with Arl11 and determine their functional significance.
While vesicle trafficking is the most commonly suggested function of Arl11, its role in other cellular processes cannot be ruled out. Further research may uncover additional functions and pathways influenced by Arl11, contributing to a comprehensive understanding of its biological roles.
Customer Reviews (8)
Write a reviewBy incorporating Arl11 protein into electron microscopy studies, researchers have gained valuable insights into protein interactions and conformational changes, contributing to a deeper understanding of complex cellular processes.
Their extensive technical expertise and assistance are invaluable in overcoming any challenges that may arise during the experimental process.
Its stability and well-defined structure make it an excellent candidate for visualizing and studying the three-dimensional arrangement of proteins at a high resolution.
Its reliability in ELISA makes it a trusted tool for quantitative and qualitative protein analysis.
the manufacturer's commitment to customer satisfaction extends beyond technical support. They offer a comprehensive range of related products and resources to aid researchers in their trials.
Ankar protein has been successfully utilized in protein electron microscopy structure analysis.
From troubleshooting to optimizing experimental protocols, the manufacturer provides diligent support to ensure the success of the trial.
This property is particularly beneficial for long-term trials or experiments with extended durations, ensuring consistent performance throughout the entire study period.
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