ARL4D
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Official Full Name
ADP-ribosylation factor-like 4D
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Overview
ADP-ribosylation factor 4D is a member of the ADP-ribosylation factor family of GTP-binding proteins. ARL4D is closely similar to ARL4A and ARL4C and each has a nuclear localization signal and an unusually high guanine nucleotide exchange rate. This protein may play a role in membrane-associated intracellular trafficking. Mutations in this gene have been associated with Bardet-Biedl syndrome (BBS). -
Synonyms
ARL4D; ADP-ribosylation factor-like 4D; ADP ribosylation factor 4 like , ARF4L; ADP-ribosylation factor-like protein 4D; ADP ribosylation factor 4 like; ADP ribosylation factor like 4D; ADP ribosylation factor like 6; ADP ribosylation factor like protein 4D; ADP ribosylation factor like protein 4L; ADP-ribosylation factor-like protein 4L; AR L6; ARF 4L; ARF4L; ARL 4D; ARL 6; ARL4D_HUMAN; ARL6; ADP-ribosylation factor-like 6;
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Human
- Mouse
- Rhesus Macaque
- Zebrafish
- E.coli
- HEK293
- In Vitro Cell Free System
- Mammalian Cell
- Wheat Germ
- GST
- His
- His (Fc)
- Avi
- N/A
- Involved Pathway
- Protein Function
- Interacting Protein
- ARL4D Related Articles
ARL4D involved in several pathways and played different roles in them. We selected most pathways ARL4D participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with ARL4D were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name | Pathway Related Protein |
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ARL4D has several biochemical functions, for example, GTP binding, GTPase activity, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by ARL4D itself. We selected most functions ARL4D had, and list some proteins which have the same functions with ARL4D. You can find most of the proteins on our site.
Function | Related Protein |
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GTP binding | GNAO1A;RAB1;RHOF;ARF6B;RHOBTB1;MOCS1;ARF1L;HRASA;RAB1BA |
GTPase activity | RAB33B;RAB24;GNAI2;RAB42A;GBP3;GBP1;RAB1BB;TUBA1L2;ARL4C |
protein binding | PDCD5;BAI2;SDCBP;TRAF1;CSF2;SF3B4;DAO;SLC9A3;LLGL2 |
ARL4D has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ARL4D here. Most of them are supplied by our site. Hope this information will be useful for your research of ARL4D.
CCDC102B; EPRS; PRKCSH; PGAM1; DNAJA1; SNRPN; TLE1; UNC119; EIF2B1; UBR1; CNPY4; NDRG1; TMEM230; EML4; MAPK8IP3
- Q&As
- Reviews
Q&As (16)
Ask a questionAlthough rare, some genetic mutations in ARL4D have been identified in certain diseases. For example, mutations in ARL4D have been associated with retinitis pigmentosa, a genetic disorder affecting the retina. However, further studies are needed to fully understand the extent and implications of these mutations.
Yes, alterations in ARL4D expression can impact various cellular behaviors. Increased expression of ARL4D has been associated with enhanced cell migration, invasion, and metastasis in cancer cells. Additionally, aberrant ARL4D expression may disrupt normal cellular processes, leading to disease phenotypes.
ARL4D has been associated with various diseases and pathological conditions. Its dysregulation has been observed in several types of cancer, where increased expression of ARL4D has been linked to enhanced metastatic potential and poor patient prognosis. ARL4D has also been implicated in neurodegenerative diseases, where it may contribute to abnormal vesicular trafficking and protein aggregation in neurons.
Yes, ARL4D can undergo post-translational modifications, including prenylation and palmitoylation. These lipid modifications help anchor ARL4D to cellular membranes, thus influencing its subcellular localization and activity.
While there are currently no reports of disease-specific mutations in the ARL4D gene, dysregulation of ARL4D expression levels has been observed in certain diseases, particularly cancer. Investigations into potential ARL4D mutations and their impact on disease development are ongoing.
Yes, ARL4D has been implicated in signal transduction pathways. It has been shown to modulate the activity of Rho family GTPases, such as Rac1 and Cdc42, which are key regulators of cytoskeletal dynamics and cellular signaling. ARL4D can also interact with and regulate other signaling proteins involved in vesicular trafficking and cellular processes.
ARL4D has been implicated in several diseases and disorders. For example, it has been linked to the progression of cancer, where abnormal expression of ARL4D can contribute to tumor growth, metastasis, and drug resistance. Its dysregulation has also been associated with neurological disorders and retinal diseases.
While there are currently no specific drugs targeting ARL4D, its involvement in various diseases makes it a potential therapeutic target. Understanding the underlying mechanisms of ARL4D function and identifying small molecules or inhibitors that can modulate its activity may hold promise for developing therapeutic interventions in the future.
ARL4D is involved in several cellular processes. It plays a role in vesicular trafficking, including the regulation of endosome organization, protein sorting, and membrane trafficking. ARL4D also contributes to cytoskeletal organization by promoting actin filament assembly and stabilization. Moreover, it has been implicated in cell migration, invasion, and metastasis in cancer cells.
Studies involving ARL4D knockdown or knockout have shown various functional consequences. Knockdown or depletion of ARL4D has been reported to inhibit cell migration and invasion, reduce actin polymerization, and impair endocytic trafficking. Furthermore, ARL4D knockout in animal models has revealed defects in embryonic development and impaired neuronal migration.
The potential therapeutic targeting of ARL4D is an area of ongoing research. Given its involvement in cancer progression and other diseases, there is interest in exploring the development of drugs or strategies to modulate its activity for therapeutic purposes.
Yes, several proteins have been identified as interacting partners of ARL4D. Some examples include the ARF-like protein 4 (ARL4A), ARF-like protein 4B (ARL4B), ARL4C, and ARL4-like protein (ARL4L), which belong to the same family of small GTPases. Other interacting proteins include certain Rab GTPases, Rho family GTPases (such as Rac1 and Cdc42), and various effector proteins involved in vesicular trafficking and cytoskeletal dynamics.
Yes, ARL4D is evolutionarily conserved among different species. Homologs of ARL4D can be found in organisms ranging from yeast to humans, suggesting its importance in fundamental cellular processes. The amino acid sequences and functional domains of ARL4D show significant conservation across species.
Currently, there are limited specific inhibitors or activators targeting ARL4D. However, studies focused on understanding the regulatory mechanisms and identifying small molecules that modulate ARL4D's activity may pave the way for developing drugs that can target this protein.
ARL4D influences cytoskeletal organization by interacting with and regulating the activity of actin-binding proteins. It promotes actin filament assembly and stabilization, leading to the formation of actin-rich structures such as lamellipodia and filopodia necessary for cell migration and shape changes.
ARL4D interacts with various binding partners to perform its functions. Some of its known interacting proteins include effector proteins involved in vesicle trafficking (such as ARF-binding proteins), regulators of actin cytoskeleton dynamics, and signaling molecules like kinases and GTPase-activating proteins.
Customer Reviews (8)
Write a reviewThis unique capability to selectively bind to exposed PS simplifies the identification and quantification of different cellular populations, reducing experimental errors and enhancing accuracy.
By choosing the ARL4D protein and partnering with the manufacturer, researchers can confidently conduct their trials, achieve reliable results, and contribute to groundbreaking discoveries.
Collaborating with the manufacturer opens up possibilities for potential collaboration and exchange of information with a wider scientific community, allowing researchers to stay at the forefront of advancements in their respective fields.
This includes complementary reagents, protocols, and access to an extensive knowledge base, all aimed at streamlining the trial process and maximizing the chances of achieving meaningful results.
the ARL4D protein offers numerous advantages for researchers conducting trials due to its high quality and stability.
This may include providing detailed protocols, troubleshooting guidance, and access to knowledgeable experts who can answer any inquiries or concerns.
Its stability and purity make it an ideal candidate for studying protein structures at a high resolution, providing crucial insights into the organization and function of the ARL4D protein.
They can provide technical assistance, ensuring optimal utilization of the product.
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