ARPP19
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Official Full Name
ARPP19 cAMP-regulated phosphoprotein, 19kDa [ Homo sapiens ]
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Overview
The 19-kD cAMP-regulated phosphoprotein plays a role in regulating mitosis by inhibiting protein phosphatase-2A (PP2A; see MIM 176915) (summary by Gharbi-Ayachi et al., 2010 [PubMed 21164014]). -
Synonyms
ARP19; ARPP-16; ARPP-19; ARPP16; ARPP19; cAMP-regulated phosphoprotein 19; FLJ41622; cyclic AMP phosphoprotein, 19 kD; ENSAL;
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Chicken
- Human
- Rat
- Rhesus Macaque
- E.coli
- HEK293
- In Vitro Cell Free System
- Mammalian Cell
- Wheat Germ
- GST
- His
- His (Fc)
- Avi
- N/A
- Involved Pathway
- Protein Function
- Interacting Protein
ARPP19 involved in several pathways and played different roles in them. We selected most pathways ARPP19 participated on our site, such as Cell Cycle, Cell Cycle, Mitotic, M Phase, which may be useful for your reference. Also, other proteins which involved in the same pathway with ARPP19 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Cell Cycle | CLASP1;MCM6L;YWHABA;WAPAL;ORC3;ESPL1;GORASP1;MCM4;ORC1L |
| Cell Cycle, Mitotic | CEP72;BLZF1;CEP290;CTDNEP1B;TMPO;FOXM1;ARPP19;CETN2;SMC2 |
| M Phase | NCAPD2;B9D2;SETA;CTDNEP1B;ARPP19B;ZWINT;NUDC;NCAPG;CENPH |
| MASTL Facilitates Mitotic Progression | ARPP19B;ENSA;ENSAA;MASTL;ARPP19A;ARPP19;ENSAB |
| Mitotic Prophase | CTDNEP1;SETA;ENSAB;DULLARD;SET;TMEM188;NEK9;NEK6;CTDNEP1A |
ARPP19 has several biochemical functions, for example, phosphatase inhibitor activity, potassium channel regulator activity, protein phosphatase 2A binding. Some of the functions are cooperated with other proteins, some of the functions could acted by ARPP19 itself. We selected most functions ARPP19 had, and list some proteins which have the same functions with ARPP19. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| phosphatase inhibitor activity | TESC;ENSA;URI1;ENSAA;ARPP19;ANP32E |
| potassium channel regulator activity | ARPP19;AMIGO1;SUMO1;KCNMB3;KCNIP3;DRD2;ANK2;SGK2;SGK1 |
| protein phosphatase 2A binding | MASTL;EIF4EBP1;GRIN3A;PPME1;PPP2R2A;TP53;SMG7;RPS6KB1;CTTNBP2NL |
| protein phosphatase inhibitor activity | PPP1R1C;PHACTR1;GLC8;ELFN2;ELFN1;ARPP19;PPP1R14C;PPP1R27;PPP1R10 |
| protein phosphatase type 2A regulator activity | PPP2R2A;PPP2R2C;PPP2R4;PPP2R2BB;PPP2R2D;PPP2R1A;PPP2R1B;PPP2R5C;PPP2R5EA |
| receptor binding | FGF20A;NRG1;LAMA1;NCR3;WNT7AA;PGR;ACOX2;RND1;VTCN1 |
ARPP19 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ARPP19 here. Most of them are supplied by our site. Hope this information will be useful for your research of ARPP19.
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- Q&As
- Reviews
Q&As (5)
Ask a questionThe regulation of ARPP19 expression is not extensively studied. However, some studies have suggested that its expression can be modulated in response to various signaling pathways, hormones, and stress conditions.
Yes, ARPP19 has been found to interact with several proteins, including PP1, calcineurin, GAPDH, NudC, and NudCL2. These interactions might contribute to the modulation of PP1 activity and other cellular processes.
ARPP19 protein has been observed to form homodimers, meaning it can bind to itself and create dimers. This dimerization might play a role in its function and regulation.
To date, no specific diseases or conditions have been directly linked to abnormalities in ARPP19 protein expression or function. However, further research is necessary to explore any potential associations.
Yes, ARPP19 can undergo phosphorylation at specific sites, which might regulate its activity or interactions with other proteins. However, the exact functional consequences of these modifications are still under investigation.
Customer Reviews (3)
Write a reviewThe knowledgeable and experienced support team is readily available to address any questions or concerns that researchers may have throughout their experimental journey.
Its stability and reliability warrant its inclusion in my research protocols, leading to meaningful and conclusive results.
One remarkable aspect of working with the ARPP19 protein is the excellent technical support provided by its manufacturer.
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