Recombinant Human ARPP19 Protein, GST-tagged

• Cat.No.: ARPP19-154H
• Product Overview: Recombinant Human ARPP19 fused with GST tag at N-terminal was expressed in Insect cells.

Specification

• Description: ARPP19, cAMP-regulated phosphoprotein 19, is specifically phosphorylated at Ser-62 during mitosis by MASTL, also known as the Greatwall kinase. The phos-phorylation of ARPP19 leads to inactivation of PP2A through its interaction with PR55-delta, which is essential in maintaining the activity of CDK1/cyclin B1 and promoting mitotic G2/M transition. Significant reduction of ARPP-19 was observed in brains of Alzheimer’s disease and Down syndrome. ARPP-19 was also found to contribute to tumor growth in hepatocellular carcinoma and papillary carcinoma.
• Source: E. coli
• Species: Human
• Tag: GST
• Form: 50mM sodium phosphate, pH 7.0, 300mM NaCl, 150mM imidazole, 0.1mM PMSF, 0.25mM DTT, 25% glycerol
• Molecular Mass: 46 kDa
• Purity: > 95%
• Applications: Western Blot
• Stability: 1 year at -70 centigrade from date of shipment.
• Storage: Store product at –70centigrade. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
• Concentration: 0.5 ug/ml

Gene Information

• Gene Name: ARPP19 cAMP-regulated phosphoprotein, 19kDa [ Homo sapiens(human) ]
• Official Symbol: ARPP19
• Synonyms: ARPP19; ENSAL; ARPP16; ARPP-16; ARPP-19; cAMP-regulated phosphoprotein, 19kDa; cAMP-regulated phosphoprotein 19; cyclic AMP phosphoprotein, 19 kD
• Gene ID: 10776
• mRNA Refseq: NM_006628
• Protein Refseq: NP_006619
• MIM: 605487
• UniProt ID: P56211