ASCC1
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Official Full Name
activating signal cointegrator 1 complex subunit 1
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Synonyms
ASCC1; activating signal cointegrator 1 complex subunit 1; ASC1p50; CGI 18; Em:AC022392.3; ASC-1 complex subunit p50; ASC1 complex subunit p50; ASCC1_HUMAN; RP11-150D20.4; Trip4 complex subunit p50; p50; CGI-18;
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Human
- Mouse
- Rhesus Macaque
- Zebrafish
- E.coli
- HEK293
- HEK293T
- In Vitro Cell Free System
- Mammalian Cell
- Wheat Germ
- GST
- His
- His (Fc)
- Avi
- Myc
- DDK
- N/A
- Involved Pathway
- Protein Function
- Interacting Protein
ASCC1 involved in several pathways and played different roles in them. We selected most pathways ASCC1 participated on our site, such as ALKBH3 mediated reversal of alkylation damage, DNA Damage Reversal, DNA Repair, which may be useful for your reference. Also, other proteins which involved in the same pathway with ASCC1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| ALKBH3 mediated reversal of alkylation damage | ASCC3;ALKBH3;ASCC1;ASCC2 |
| DNA Damage Reversal | ALKBH3;ASCC2;ASCC1;ALKBH2;MGMT;ASCC3 |
| DNA Repair | PAXIP1;TFPT;TDP2B;POLI;DCLRE1A;ZNF830;ZFP830;BARD1;COPS3 |
| Reversal of alkylation damage by DNA dioxygenases | ASCC3;ASCC1;ASCC2;ALKBH2;ALKBH3 |
ASCC1 has several biochemical functions, for example, RNA binding, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by ASCC1 itself. We selected most functions ASCC1 had, and list some proteins which have the same functions with ASCC1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| RNA binding | QKIA;SETD1B;MRPL23;LARP6;RC3H2;PKZ;RBM23;EXOSC1;RPL8 |
| protein binding | EYA3;CD99L2;TMEM8A;LSM6;PPM1A;EBF2;ITGB4;TRAF3;FGR |
ASCC1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ASCC1 here. Most of them are supplied by our site. Hope this information will be useful for your research of ASCC1.
TRAF2; NAA38
- Q&As
- Reviews
Q&As (7)
Ask a questionASCC1 is primarily localized in the nucleus of cells, where it functions in gene expression regulation. It is believed to shuttle between the nucleus and cytoplasm upon specific cellular signaling events.
The post-translational modifications of ASCC1 have not been extensively studied. However, it is possible that ASCC1 undergoes modifications such as phosphorylation or acetylation, which can regulate its function.
Yes, ASCC1 is involved in DNA repair processes as part of the ASC-1 complex. It participates in the repair of DNA double-strand breaks, contributing to genome stability.
ASCC1 is expressed in a wide range of tissues and cell types, including but not limited to the brain, liver, heart, and skeletal muscle.
Currently, there are no known human diseases directly associated with ASCC1. However, dysregulation of transcriptional coactivation complexes, in which ASCC1 is involved, can contribute to various diseases.
Given the limited understanding of ASCC1's specific role in diseases, it is currently uncertain if it can be directly targeted for therapeutic interventions or drug discovery.
ASCC1 interacts with various proteins and transcription factors, such as ATF2, TAF12, and TRIM28, to form the ASC-1 complex and regulate gene expression.
Customer Reviews (3)
Write a reviewthe use of ASCC1 protein in my research offers significant advantages in detecting cell death processes and investigating coagulation and thrombosis mechanisms.
The manufacturer's support and expertise further enhance the utility of ASCC1 in my experimental work, ensuring reliable and high-quality results.
This collaborative partnership greatly contributes to the success of my research projects and facilitates meaningful contributions to the scientific community.
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