Recombinant Human ASCC1 protein, GST-tagged

• Cat.No.: ASCC1-899H
• Product Overview: Human ASCC1 full-length ORF ( NP_057031.2, 1 a.a. - 357 a.a.) recombinant protein with GST-tag at N-terminal.

Specification

• Description: This gene encodes a subunit of the activating signal cointegrator 1 (ASC-1) complex. The ASC-1 complex is a transcriptional coactivator that plays an important role in gene transactivation by multiple transcription factors including activating protein 1 (AP-1), nuclear factor kappa-B (NF-kB) and serum response factor (SRF). The encoded protein contains an N-terminal KH-type RNA-binding motif which is required for AP-1 transactivation by the ASC-1 complex. Mutations in this gene are associated with Barrett esophagus and esophageal adenocarcinoma. Alternatively spliced transcripts encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Dec 2011]
• Source: Wheat Germ
• Species: Human
• Tag: GST
• Molecular Mass: 67.6 kDa
• AA Sequence: MEVLRPQLIRIDGRNYRKNPVQEQT YQHEEDEEDFYQGSMECADEPCDAY EVEQTPQGFRSTLRAPSLLYKHIVG KRGDTRKKIEMETKTSISIPKPGQD GEIVITGQHRNGVISARTRIDVLLD TFRRKQPFTHFLAFFLNEVEVQEGF LRFQEEVLAKCSMDHGVDSSIFQNP KKLHLTIGMLVLLSEEEIQQTCEML QQCKEEFINDISGGKPLEVEMAGIE YMNDDPGMVDVLYAKVHMKDGSNRL QELVDRVLERFQASGLIVKEWNSVK LHATVMNTLFRKDPNAEGRYNLYTA EGKYIFKERESFDGRNILKLFENFY FGSLKLNSIHISQRFTVDSFGNYAS CGQIDFS
• Applications: Enzyme-linked Immunoabsorbent Assay; Western Blot (Recombinant protein); Antibody Production; Protein Array
• Notes: Best use within three months from the date of receipt of this protein.
• Storage: Store at -80 centigrade. Aliquot to avoid repeated freezing and thawing.
• Storage Buffer: 50 mM Tris-HCI, 10 mM reduced Glutathione, pH=8.0 in the elution buffer.

Gene Information

• Gene Name: ASCC1 activating signal cointegrator 1 complex subunit 1 [ Homo sapiens ]
• Official Symbol: ASCC1
• Synonyms: ASCC1; activating signal cointegrator 1 complex subunit 1; ASC1p50; CGI 18; Em:AC022392.3; ASC-1 complex subunit P50; trip4 complex subunit p50; p50; CGI-18
• Gene ID: 51008
• mRNA Refseq: NM_001198798
• Protein Refseq: NP_001185727
• MIM: 614215
• UniProt ID: Q8N9N2