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Official Full Name activating transcription factor 6
Background This gene encodes a transcription factor that activates target genes for the unfolded protein response (UPR) during endoplasmic reticulum (ER) stress. Although it is a transcription factor, this protein is unusual in that it is synthesized as a transmembrane protein that is embedded in the ER. It functions as an ER stress sensor/transducer, and following ER stress-induced proteolysis, it functions as a nuclear transcription factor via a cis-acting ER stress response element (ERSE) that is present in the promoters of genes encoding ER chaperones. This protein has been identified as a survival factor for quiescent but not proliferative squamous carcinoma cells. There have been conflicting reports about the association of polymorphisms in this gene with diabetes in different populations, but another polymorphism has been associated with increased plasma cholesterol levels. This gene is also thought to be a potential therapeutic target for cystic fibrosis. [provided by RefSeq, Aug 2011]
Synonyms ATF6; activating transcription factor 6; ATF6A; cyclic AMP-dependent transcription factor ATF-6 alpha; cAMP-dependent transcription factor ATF-6 alpha;
    • Species :
    • Human
    • Mouse
    • Rat
    • Zebrafish
    • Source :
    • E.coli
    • Mammalian Cell
    • Wheat Germ
    • Tag :
    • GST
    • His
    • T7
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human ATF6-144HCL Recombinant Human ATF6 cell lysate N/A
    Human ATF6-26190TH Recombinant Human ATF6, His-tagged E.coli His
    Human ATF6-873H Recombinant Human ATF6, GST-tagged Wheat Germ GST
    Mouse ATF6-2069M Recombinant Mouse ATF6 Protein Mammalian Cell His
    Mouse ATF6-2070M Recombinant Mouse Atf6 protein, His/T7-tagged E.coli His/T7
    Rat ATF6-841R Recombinant Rat ATF6 Protein Mammalian Cell His
    Zebrafish ATF6-6204Z Recombinant Zebrafish ATF6 Mammalian Cell His

    atf6 involved in several pathways and played different roles in them. We selected most pathways atf6 participated on our site, such as Protein processing in endoplasmic reticulum, Alzheimers disease, which may be useful for your reference. Also, other proteins which involved in the same pathway with atf6 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Protein processing in endoplasmic reticulum NSFL1C; BCAP31; ATXN3L; HSPA5; EDEM3; CAPN2; CAPN1; SEC23B; HSPH1; DNAJB1
    Alzheimers disease PLCB4; CALM3; NDUFA13; IL1B; ERN1; PPP3R1; NDUFB3; ATP5B; UQCRFS1; Atp5g2

    atf6 has several biochemical functions, for example, RNA polymerase II regulatory region sequence-specific DNA binding, cAMP response element binding, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by atf6 itself. We selected most functions atf6 had, and list some proteins which have the same functions with atf6. You can find most of the proteins on our site.

    Function Related Protein
    RNA polymerase II regulatory region sequence-specific DNA binding ZFAT; PKNOX2; TFAP2D; GATA2A; ZNF480; IRF2; ATF4B2; ASCL3; ALX4; SKINT8
    cAMP response element binding HMGA2; CREB3L3; CREB3L3A; CREB3; CREB1; ATF6B; CREB3L2; CREB3L3L; CREB3L4; JUN
    protein binding ORAI2; TEKT1; UBB; UBE2D1; EPHA4; a; PUS7L; SSSCA1; SPATA22; CATSPERB
    protein heterodimerization activity H2-AB1; CHRNA3; SOX6; KATNA1; KCNB1; AGTR1A; H3F3B; SLC51B; NOTCH1; NEFL
    transcription coactivator activity MED14; JUND; TAF7; NCOA3; RB1; SMARCA2; JUNBB; RNF20; MED1; CITED2
    transcription factor activity, sequence-specific DNA binding ZNF624; TAF6; FOXO1A; E2F8; SMAD1; ZBTB25; ZNF480; PPARA; PHTF1; SPI1

    atf6 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with atf6 here. Most of them are supplied by our site. Hope this information will be useful for your research of atf6.

    CREB3L3; XBP1; Klc2; BPGM; CREB1; TNFRSF1A; DDC; p27958-pro_0000037575; NNMT; BALF4 (provisional); NFYC; dppA; papC; fhuB; q8d1i7_yerpe; y1009_yerpe

    Wang, JJ; Cheng, QY; et al. Deficiency of IRE1 and PERK Signal Pathways in Systemic Lupus Erythematosus. AMERICAN JOURNAL OF THE MEDICAL SCIENCES 348:465-473(2014).
    Park, KS; Bayles, I; et al. Transcription Elongation Factor ELL2 Drives Ig Secretory-Specific mRNA Production and the Unfolded Protein Response. JOURNAL OF IMMUNOLOGY 193:4663-4674(2014).

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