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Official Full Name ATG4 autophagy related 4 homolog A
Background Autophagy is a catabolic process for the autophagosomic-lysosomal degradation of bulk cytoplasmic contents. Control of autophagy was largely discovered in yeast and involves proteins encoded by a set of autophagy-related genes (Atg) (1). Formation of auto
Synonyms ATG4A; ATG4 autophagy related 4 homolog A (S. cerevisiae); APG4 autophagy 4 homolog A (S. cerevisiae) , APG4A, AUT like 2, cysteine endopeptidase (S. cerevisiae) , AUTL2; cysteine protease ATG4A; hAPG4A; autophagin 2; autophagin-2; APG4 autophagy 4 homol
    • Species :
    • Chicken
    • Human
    • Rhesus Macaque
    • Zebrafish
    • Source :
    • E.coli
    • Mammalian Cell
    • Wheat Germ
    • Tag :
    • GST
    • His
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human ATG4A-36H Recombinant Human ATG4A, His-tagged E.coli His
    Human ATG4A-948H Recombinant Human ATG4A protein, GST-tagged Wheat Germ GST
    Rhesus Macaque ATG4A-441R Recombinant Rhesus monkey ATG4A Protein, His-tagged Mammalian Cell His
    Chicken ATG4A-4695C Recombinant Chicken ATG4A Mammalian Cell His
    Chicken ATG4A-4696C Recombinant Chicken ATG4A Mammalian Cell His
    Zebrafish ATG4A-3034Z Recombinant Zebrafish ATG4A Mammalian Cell His

    ATG4A involved in several pathways and played different roles in them. We selected most pathways ATG4A participated on our site, such as Cellular responses to stress, Macroautophagy, Regulation of autophagy, which may be useful for your reference. Also, other proteins which involved in the same pathway with ATG4A were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Cellular responses to stress HIST3H2BB; WDR45; CBX8; EED; HSBP1; EGLN3; C7orf59; NUPL2; EGLN2; TXN
    Macroautophagy GABARAPL2; ATG101; MAP1LC3B; WDR45; ULK1A; WDR45L; WIPI1; RB1CC1; WIPI2; AMBRA1B
    Regulation of autophagy IFNA21; IFNA16; GABARAPL2; IFNG; ATG13; IFNPHI1; ATG5; IFNA2; INS1; IFNA14

    ATG4A has several biochemical functions, for example, cysteine-type endopeptidase activity, cysteine-type peptidase activity, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by ATG4A itself. We selected most functions ATG4A had, and list some proteins which have the same functions with ATG4A. You can find most of the proteins on our site.

    Function Related Protein
    cysteine-type endopeptidase activity MALT1A; CASP1; CASPA; USP12A; CASP3A; USP47; CTSF; USP22; USP17L5; PSD
    cysteine-type peptidase activity UFSP2; CTSZ; OTULIN; CASP5; Ctsl; PSD; CASP7; USP43A; DUB1; CTSLL
    protein binding IQCE; CEACAM21; GATAD2B; NVL; ARIH2; KCNQ1; GADD45GIP1; GTF2H4; RPRD1B; IDE

    ATG4A has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ATG4A here. Most of them are supplied by our site. Hope this information will be useful for your research of ATG4A.


    Fan, JD; Lei, PJ; et al. The Selective Activation of p53 Target Genes Regulated by SMYD2 in BIX-01294 Induced Autophagy-Related Cell Death. PLOS ONE 10:-(2015).
    Liao, YP; Chen, LY; et al. Hypomethylation signature of tumor-initiating cells predicts poor prognosis of ovarian cancer patients. HUMAN MOLECULAR GENETICS 23:1894-1906(2014).

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