ATP1B4
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Official Full Name
ATPase, Na+/K+ transporting, beta 4 polypeptide
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Overview
This gene has been found in all vertebrate genomes sequenced to date. However, this gene has undergone a change in function in placental mammals compared to other species. Specifically, in fish, avian, and amphibian species, this gene encodes plasma membrane-bound beta-subunits of Na,K-ATPase. In placental mammals, the encoded protein interacts with the nuclear transcriptional coregulator SKIP and may be involved in the regulation of TGF-beta signaling. Two transcript variants encoding different isoforms have been found for this gene. -
Synonyms
ATP1B4; ATPase, Na+/K+ transporting, beta 4 polypeptide; ATPase, (Na+)/K+ transporting, beta 4 polypeptide; protein ATP1B4; X,K-ATPase beta-m subunit; x/potassium-transporting ATPase subunit beta-m;
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Bos taurus (Bovine)
- Chicken
- Homo sapiens (Human)
- Human
- Mouse
- Mus musculus (Mouse)
- Rat
- Rattus norvegicus (Rat)
- Sus scrofa (Pig)
- E.coli
- E.coli expression system
- HEK293
- HEK293T
- In Vitro Cell Free System
- Mammalian Cell
- Wheat Germ
- His
- Fc
- Avi
- T7
- Myc
- DDK
- Non
| Species | Cat.# | Product name | Source (Host) | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| Human | ATP1B4-968H | Recombinant Human ATP1B4 protein | Wheat Germ | Non |
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| Human | ATP1B4-48HCL | Recombinant Human ATP1B4 lysate | HEK293 | Non |
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| Human | ATP1B4-2941H | Recombinant Human ATP1B4 Protein, MYC/DDK-tagged | HEK293 | Myc&DDK |
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| Human | ATP1B4-3984H | Recombinant Human ATP1B4 Protein, Myc/DDK-tagged, C13 and N15-labeled | HEK293T | Myc&DDK |
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| Human | ATP1B4-1150HF | Recombinant Full Length Human ATP1B4 Protein | In Vitro Cell Free System | 357 amino acids |
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| Human | ATP1B4-1263H | Recombinant Human ATP1B4 protein, His-tagged | E.coli | His | Tyr132-Thr357 |
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| Mouse | ATP1B4-2119M | Recombinant Mouse ATP1B4 Protein | Mammalian Cell | His |
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| Mouse | Atp1b4-1765M | Recombinant Mouse Atp1b4 Protein, Myc/DDK-tagged | HEK293T | Myc&DDK |
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| Mouse | ATP1B4-853M-B | Recombinant Mouse ATP1B4 Protein Pre-coupled Magnetic Beads | HEK293 |
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| Mouse | ATP1B4-853M | Recombinant Mouse ATP1B4 Protein, His (Fc)-Avi-tagged | HEK293 | His&Fc&Avi |
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| Rat | ATP1B4-858R | Recombinant Rat ATP1B4 Protein | Mammalian Cell | His |
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| Rat | ATP1B4-514R | Recombinant Rat ATP1B4 Protein, His (Fc)-Avi-tagged | HEK293 | His&Fc&Avi |
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| Rat | ATP1B4-514R-B | Recombinant Rat ATP1B4 Protein Pre-coupled Magnetic Beads | HEK293 |
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| Rat | ATP1B4-1535R | Recombinant Rat ATP1B4 protein, His & T7-tagged | E.coli | His&T7 | Met132~Thr356 (Accession # Q9R193) |
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| Bos taurus (Bovine) | RFL-8137BF | Recombinant Full Length Bovine Protein Atp1B4(Atp1B4) Protein, His-Tagged | E.coli expression system | His | Full Length (1-355) |
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| Homo sapiens (Human) | RFL3932HF | Recombinant Full Length Human Protein Atp1B4(Atp1B4) Protein, His-Tagged | E.coli expression system | His | Full Length (1-357) |
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| Mus musculus (Mouse) | RFL32807MF | Recombinant Full Length Mouse Protein Atp1B4(Atp1B4) Protein, His-Tagged | E.coli expression system | His | Full Length (1-356) |
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| Rattus norvegicus (Rat) | RFL31599RF | Recombinant Full Length Rat Protein Atp1B4(Atp1B4) Protein, His-Tagged | E.coli expression system | His | Full Length (1-356) |
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| Sus scrofa (Pig) | RFL25540SF | Recombinant Full Length Pig Protein Atp1B4(Atp1B4) Protein, His-Tagged | E.coli expression system | His | Full Length (1-355) |
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| Chicken | ATP1B4-3443C | Recombinant Chicken ATP1B4 | Mammalian Cell | His |
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- Involved Pathway
- Protein Function
- Interacting Protein
- Other Resource
ATP1B4 involved in several pathways and played different roles in them. We selected most pathways ATP1B4 participated on our site, such as cGMP-PKG signaling pathway, cAMP signaling pathway, Cardiac muscle contraction, which may be useful for your reference. Also, other proteins which involved in the same pathway with ATP1B4 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| cGMP-PKG signaling pathway | GNA12;PDE3A;ATP1A3;PLN;CREB3L3;PPP3CA;AGTR1A;VDAC1;OPRD1 |
| cAMP signaling pathway | HCAR3;CREB3L1;GRIN3B;CAMK2D;ROCK1;PDE4C;RRAS2;RAP1B;PPP1CC |
| Cardiac muscle contraction | ATP1B4;TPM4B;CACNG2A;UQCRC2A;TNNC1;COX6A2;CACNG8;UQCRC2B;ATP1B3A |
| Adrenergic signaling in cardiomyocytes | AGTR1B;PPP2R5E;MYL2B;MAPK12;CALM2;ATF2;ATP1A1A.1;TNNC1A;MAPK14 |
| Insulin secretion | ATP1B4;PDX1;GNAQ;CCKAR;SNAP25;KCNN3;ITPR3;CAMK2G;Adcy4 |
| Thyroid hormone synthesis | PLCB4;HSPA5;GPX7;TSHB;GPX2;ATP1B2;ATP1A1;ASGR2;GPX8 |
| Thyroid hormone signaling pathway | PLN;WNT4;PLCB4;CCND1;RHEB;PFKFB2;PRKCA;CASP9;SLC2A1 |
| Aldosterone-regulated sodium reabsorption | INS;SLC9A3R2;MAPK1;PIK3R5;INS1;FXYD2;FXYD4;PIK3R2;INS2 |
| Endocrine and other factor-regulated calcium reabsorption | RAB11A;BDKRB2;KLK1B11;GNAS;KLK1B24;VDR;ATP1A4;KLK1;KLK1B22 |
| Proximal tubule bicarbonate reclamation | ATP1B3;Car2;SLC9A3;PCK1;AQP1;ATP1A4;SLC38A3;GLUD2;SLC25A10 |
| Salivary secretion | PRKG2;GUCY1B3;SLC9A1;ATP1B4;CST1;PLCB1;PRKCA;CALM3;BST1 |
| Gastric acid secretion | SST;SSTR2;SLC9A1;GNAS;GAST;KCNJ15;CAMK2A;KCNJ10;GNAI3 |
| Pancreatic secretion | PLA2G1B;PLCB3;ATP1B2;PLCB1;RAP1A;ATP1A1;SLC4A4;FXYD2;CLCA4 |
| Carbohydrate digestion and absorption | FXYD2;SLC2A2;G6PC3;HK2;ATP1B1;AMY2B;PIK3CD;G6PC;PIK3CG |
| Protein digestion and absorption | CPA1;SLC36A1;CPB1;KCNJ13;KCNK5;SLC16A10;SLC7A7;KCNE3;SLC8A2 |
| Bile secretion | SCARB1;ADCY9;AQP8;HMGCR;SLC51A;OSTA;FAM84B;SLCO1B3;SLC2A1 |
| Mineral absorption | STEAP2;SLC9A3;MT1B;ATP2B1;MT2;FTL;SLC46A1;ATP7A;MT1F |
ATP1B4 has several biochemical functions, for example, monovalent inorganic cation transmembrane transporter activity. Some of the functions are cooperated with other proteins, some of the functions could acted by ATP1B4 itself. We selected most functions ATP1B4 had, and list some proteins which have the same functions with ATP1B4. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| monovalent inorganic cation transmembrane transporter activity |
ATP1B4 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ATP1B4 here. Most of them are supplied by our site. Hope this information will be useful for your research of ATP1B4.
Research Area
Related articles
Gao, K; Song, Z; et al. Genetic analysis of the ATP1B4 gene in Chinese Han patients with Parkinson's disease. MOLECULAR BIOLOGY REPORTS 41:2307-2311(2014).
Sarkozy, M; Zvara, A; et al. Metabolic syndrome influences cardiac gene expression pattern at the transcript level in male ZDF rats. CARDIOVASCULAR DIABETOLOGY 12:-(2013).
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