ATP1B4

  • Official Full Name

    ATPase, Na+/K+ transporting, beta 4 polypeptide

  • Overview

    This gene has been found in all vertebrate genomes sequenced to date. However, this gene has undergone a change in function in placental mammals compared to other species. Specifically, in fish, avian, and amphibian species, this gene encodes plasma membrane-bound beta-subunits of Na,K-ATPase. In placental mammals, the encoded protein interacts with the nuclear transcriptional coregulator SKIP and may be involved in the regulation of TGF-beta signaling. Two transcript variants encoding different isoforms have been found for this gene.
  • Synonyms

    ATP1B4; ATPase, Na+/K+ transporting, beta 4 polypeptide; ATPase, (Na+)/K+ transporting, beta 4 polypeptide; protein ATP1B4; X,K-ATPase beta-m subunit; x/potassium-transporting ATPase subunit beta-m;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Bos taurus (Bovine)
  • Chicken
  • Homo sapiens (Human)
  • Human
  • Mouse
  • Mus musculus (Mouse)
  • Rat
  • Rattus norvegicus (Rat)
  • Sus scrofa (Pig)
  • E.coli
  • E.coli expression system
  • HEK293
  • HEK293T
  • In Vitro Cell Free System
  • Mammalian Cell
  • Wheat Germ
  • His
  • His (Fc)
  • Avi
  • His|T7
  • Myc
  • DDK
  • Myc|DDK
  • N/A
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human ATP1B4-968H Recombinant Human ATP1B4 protein Wheat Germ N/A
Human ATP1B4-48HCL Recombinant Human ATP1B4 lysate HEK293 N/A
Human ATP1B4-2941H Recombinant Human ATP1B4 Protein, MYC/DDK-tagged HEK293 Myc/DDK
Human ATP1B4-3984H Recombinant Human ATP1B4 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human ATP1B4-1150HF Recombinant Full Length Human ATP1B4 Protein In Vitro Cell Free System 357 amino acids
Human ATP1B4-1263H Recombinant Human ATP1B4 protein, His-tagged E.coli His Tyr132-Thr357
Mouse ATP1B4-2119M Recombinant Mouse ATP1B4 Protein Mammalian Cell His
Mouse Atp1b4-1765M Recombinant Mouse Atp1b4 Protein, Myc/DDK-tagged HEK293T Myc/DDK
Mouse ATP1B4-853M-B Recombinant Mouse ATP1B4 Protein Pre-coupled Magnetic Beads HEK293
Mouse ATP1B4-853M Recombinant Mouse ATP1B4 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat ATP1B4-858R Recombinant Rat ATP1B4 Protein Mammalian Cell His
Rat ATP1B4-514R Recombinant Rat ATP1B4 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat ATP1B4-514R-B Recombinant Rat ATP1B4 Protein Pre-coupled Magnetic Beads HEK293
Rat ATP1B4-1535R Recombinant Rat ATP1B4 protein, His & T7-tagged E.coli His/T7 Met132~Thr356 (Accession # Q9R193)
Bos taurus (Bovine) RFL-8137BF Recombinant Full Length Bovine Protein Atp1B4(Atp1B4) Protein, His-Tagged E.coli expression system His Full Length (1-355)
Homo sapiens (Human) RFL3932HF Recombinant Full Length Human Protein Atp1B4(Atp1B4) Protein, His-Tagged E.coli expression system His Full Length (1-357)
Mus musculus (Mouse) RFL32807MF Recombinant Full Length Mouse Protein Atp1B4(Atp1B4) Protein, His-Tagged E.coli expression system His Full Length (1-356)
Rattus norvegicus (Rat) RFL31599RF Recombinant Full Length Rat Protein Atp1B4(Atp1B4) Protein, His-Tagged E.coli expression system His Full Length (1-356)
Sus scrofa (Pig) RFL25540SF Recombinant Full Length Pig Protein Atp1B4(Atp1B4) Protein, His-Tagged E.coli expression system His Full Length (1-355)
Chicken ATP1B4-3443C Recombinant Chicken ATP1B4 Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • ATP1B4 Related Articles

ATP1B4 involved in several pathways and played different roles in them. We selected most pathways ATP1B4 participated on our site, such as cGMP-PKG signaling pathway, cAMP signaling pathway, Cardiac muscle contraction, which may be useful for your reference. Also, other proteins which involved in the same pathway with ATP1B4 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
cGMP-PKG signaling pathwayATP1B4;PRKCE;MEF2D;SLC8A2;PLCB2;MYH7;IRS2;SRF;MYLK3
cAMP signaling pathwayPPP1R12A;CREB3L1;CALM2;BDNF;ACOX3;GRIA4;MAP2K1;VIPR2;CAMK2G
Cardiac muscle contractionCOX7A2A;CACNG3;ATP1A1A.1;TNNC1B;TNNT2A;FXYD2;COX6A1;CACNA1C;TNNI3
Adrenergic signaling in cardiomyocytesADCY2B;PPP2R1B;PPP2R3A;AGTR1B;MAPK12B;CREB3L4;CACNA2D4;VMHCL;CALM1B
Insulin secretionGLP1R;ATP1A2;GPR119;KCNN4;PCLO;PLCB1;CREB3L3;KCNMA1;ATF4
Thyroid hormone synthesisTTF2;Adcy4;ATP1B1;TG;GNAQ;PRKCA;PLCB2;SLC26A4;PLCB4
Thyroid hormone signaling pathwayPIK3R2;DIO3;MED17;KAT2B;TRP53;MAPK3;BAD;SRC;PFKP
Aldosterone-regulated sodium reabsorptionFXYD2;NEDD4L;ATP1A2;ATP1A4;PIK3CA;FXYD4;INS1;SCNN1G;INS2
Endocrine and other factor-regulated calcium reabsorptionPTH1R;KLK1B9;ATP1A3;KLK1B3;KLK2;KLK1;RAB11A;ATP1A2;ATP1B3
Proximal tubule bicarbonate reclamationCar2;AQP1;GLUD1;PCK1;ATP1B4;GLS;ATP1B2;ATP1B1;GLUD2
Salivary secretionLYZ2;CD38;AMY1B;PRKG1;ATP1A4;CAMP;GUCY1A3;MUC7;CALM4
Gastric acid secretionATP1A2;PRKACG;PRKCG;PLCB2;CALM4;ATP1B3;CALML3;CA2;Slc4a2
Pancreatic secretionATP1A2;CELA2A;SLC4A4;PLA2G2D;AMY2A4;PLA2G1B;CD38;AMY2A;RAB3D
Carbohydrate digestion and absorptionATP1B1;PIK3R3;GNAT3;AMY2B;SLC2A2;ATP1A3;G6PC2;SLC37A4;ATP1B2
Protein digestion and absorptionCELA2B;PRSS2;ATP1A1;CPB1;SLC16A10;SLC36A1;SLC3A1;SLC7A8;COL4A1
Bile secretionHMGCR;AQP9;CA2;CYP3A4;SLC4A4;AQP4;SLC51A;KCNN2;RXRA
Mineral absorptionATP1A3;SLC34A2;TF;MT1H;CLCN2;Trf;SLC8A1;HMOX2;MT2A

ATP1B4 has several biochemical functions, for example, monovalent inorganic cation transmembrane transporter activity. Some of the functions are cooperated with other proteins, some of the functions could acted by ATP1B4 itself. We selected most functions ATP1B4 had, and list some proteins which have the same functions with ATP1B4. You can find most of the proteins on our site.

Function Related Protein
monovalent inorganic cation transmembrane transporter activity

ATP1B4 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ATP1B4 here. Most of them are supplied by our site. Hope this information will be useful for your research of ATP1B4.

Gao, K; Song, Z; et al. Genetic analysis of the ATP1B4 gene in Chinese Han patients with Parkinson's disease. MOLECULAR BIOLOGY REPORTS 41:2307-2311(2014).
Sarkozy, M; Zvara, A; et al. Metabolic syndrome influences cardiac gene expression pattern at the transcript level in male ZDF rats. CARDIOVASCULAR DIABETOLOGY 12:-(2013).
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