ATP2A1

  • Official Full Name

    ATPase, Ca++ transporting, cardiac muscle, fast twitch 1

  • Overview

    This gene encodes one of the SERCA Ca(2+)-ATPases, which are intracellular pumps located in the sarcoplasmic or endoplasmic reticula of muscle cells. This enzyme catalyzes the hydrolysis of ATP coupled with the translocation of calcium from the cytosol to the sarcoplasmic reticulum lumen, and is involved in muscular excitation and contraction. Mutations in this gene cause some autosomal recessive forms of Brody disease, characterized by increasing impairment of muscular relaxation during exercise. Alternative splicing results in two transcript variants encoding different isoforms.
  • Synonyms

    ATP2A1; ATPase, Ca++ transporting, cardiac muscle, fast twitch 1; ATP2A; sarcoplasmic/endoplasmic reticulum calcium ATPase 1; SERCA1; calcium pump 1; SR Ca(2+)-ATPase 1; endoplasmic reticulum class 1/2 Ca(2+) ATPase; calcium-transporting ATPase sarcoplasm;

  • Recombinant Proteins
  • Protein Pre-coupled Magnetic Beads
  • Chicken
  • Human
  • Mouse
  • Zebrafish
  • E.coli
  • HEK293
  • HEK293T
  • In Vitro Cell Free System
  • Mammalian Cell
  • Mammalian cells
  • Wheat Germ
  • Flag
  • GST
  • His
  • His (Fc)
  • Avi
  • Myc
  • DDK
  • MYC
  • Myc|DDK
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human ATP2A1-969H Recombinant Human ATP2A1 protein, GST-tagged Wheat Germ GST
Human ATP2A1-10010H Recombinant Human ATP2A1 Protein, His-tagged E.coli His 561-635 aa
Human ATP2A1-1520HFL Recombinant Full Length Human ATP2A1 Protein, C-Flag-tagged Mammalian cells Flag
Human ATP2A1-1244HF Recombinant Full Length Human ATP2A1 Protein, GST-tagged In Vitro Cell Free System GST 994 amino acids
Human ATP2A1-400H Recombinant Human ATP2A1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Human ATP2A1-2944H Recombinant Human ATP2A1 Protein, MYC/DDK-tagged HEK293 Myc/DDK
Human ATP2A1-6120H Recombinant Human ATP2A1 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human ATP2A1-400H-B Recombinant Human ATP2A1 Protein Pre-coupled Magnetic Beads HEK293
Mouse ATP2A1-2120M Recombinant Mouse ATP2A1 Protein Mammalian Cell His
Mouse ATP2A1-854M Recombinant Mouse ATP2A1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse ATP2A1-854M-B Recombinant Mouse ATP2A1 Protein Pre-coupled Magnetic Beads HEK293
Mouse Atp2a1-666M Recombinant Mouse Atp2a1 Protein, MYC/DDK-tagged HEK293T MYC/DDK
Zebrafish ATP2A1-1616Z Recombinant Zebrafish ATP2A1 Mammalian Cell His
Chicken ATP2A1-7068C Recombinant Chicken ATP2A1 Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • Other Resource

ATP2A1 involved in several pathways and played different roles in them. We selected most pathways ATP2A1 participated on our site, such as Calcium signaling pathway, cGMP-PKG signaling pathway, Pancreatic secretion, which may be useful for your reference. Also, other proteins which involved in the same pathway with ATP2A1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Calcium signaling pathwayPTGER3;ERBB2;P2RX3B;PRKACBB;ADORA2AB;PTGER1A;ORAI1B;TACR3L;PPP3R2
cGMP-PKG signaling pathwayPIK3R5;PRKG2;SRF;GNAI3;KCNMB3;NFATC4;AGTR1B;ROCK2;ATF4
Pancreatic secretionPLA2G2E;CD38;AMY2A4;AMY2A;CLCA4;RAB27B;CPA3;GNAQ;PLA2G2F
Alzheimers diseaseAPH1C;ATP5G1;NDUFS4;UQCR10;RYR3;COX4I2;HSD17B10;COX5B;PPP3R2

ATP2A1 has several biochemical functions, for example, ATP binding, calcium ion binding, calcium-transporting ATPase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by ATP2A1 itself. We selected most functions ATP2A1 had, and list some proteins which have the same functions with ATP2A1. You can find most of the proteins on our site.

Function Related Protein
ATP bindingGALK2;TGFBR1A;PLK1;PHKG1B;TTK;MYHZ2;UBE2L3A;WNK2;HIPK3A
calcium ion bindingS100A4;DSG1;MMP20;PVALB3;PCDH15;CALML4A;PSPH;PCDH15B;CHP
calcium-transporting ATPase activityATP2B2;ATP2A2A;ATP2A3;ATP2B1;ATP2C2;ATP2B4;ATP2A2;ATP2C1;ATP2B1A
protein bindingDDL-2;YY1A;HIST2H3C2;TAC1;NUTF2;USP15;AMHR2;ARPC2;Ctsl
protein homodimerization activityGNB2L1;HSF2;ENPP1;ADRA2C;LCN2;ATPIF1B;HER5;GYS2;JAM3

ATP2A1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ATP2A1 here. Most of them are supplied by our site. Hope this information will be useful for your research of ATP2A1.

TNFRSF1B; TULP3; RNF167; APPL1; 15-deoxy-delta(12,14

Research Area

Related articles

Asahi, M; Kurzydlowski, K; et al. Sarcolipin inhibits polymerization of phospholamban to induce superinhibition of sarco(endo)plasmic reticulum Ca2+-ATPases (SERCAs). JOURNAL OF BIOLOGICAL CHEMISTRY 277:26725-26728(2002).
Ji, Y; Loukianov, E; et al. SERCA1a can functionally substitute for SERCA2a in the heart. AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY 276:H89-H97(1999).
  • Q&As
  • Reviews

Q&As (6)

Ask a question
Are the expression and function of ATP2Arecombinant protein regulated in cardiomyocytes? 08/25/2022

Yes, the expression and function of ATP2A1 recombinant protein in cardiomyocytes are regulated by different regulatory mechanisms, such as endogenous hormones and signaling pathways.

What other proteins does the recombinant ATP2Aprotein interact with? 07/04/2022

The recombinant ATP2A1 protein interacts with other proteins of the sarcoplasmic reticulum, such as calsequestrin and phospholamban, to regulate muscle contraction.

Does the recombinant ATP2 Aprotein have drug target potential? 02/07/2021

The ATP2A1 recombinant protein can be used as a drug target because it plays an important role in regulating muscle and cardiomyocyte function. However, there are no clinically applicable drugs targeting ATP2A1.

What is the role of ATP2 Arecombinant protein in cardiovascular disease? 04/18/2020

Impairment of the normal function of ATP2A1 recombinant protein in cardiomyocytes may contribute to the development of cardiovascular diseases, such as reduced myocardial contractility and heart failure.

How does recombinant ATP2A protein play a role in muscle diseases? 02/28/2020

Mutations in the ATP2A1 recombinant protein may cause calcium leakage and abnormal muscle contraction, leading to muscle diseases.

How does the recombinant ATP2A protein interact with specific drugs? 10/27/2019

Certain drugs can affect the function of the recombinant ATP2A1 protein, such as calcium antagonists and cardiac agonists. These drugs regulate calcium homeostasis in muscle and cardiomyocytes.

Customer Reviews (3)

Write a review
Reviews
04/09/2022

    It is noteworthy that the results of multiple experiments were highly consistent and reproducible.

    12/19/2021

      The catalytic activity of ATP2A1 is very excellent, not only the catalytic effect is remarkable, but also has high selectivity, and its performance is impressive.

      06/28/2019

        They produced ATP2A1 with high purity and accurate experimental results.

        Ask a Question for All ATP2A1 Products

        Required fields are marked with *

        My Review for All ATP2A1 Products

        Required fields are marked with *

        logo

        FOLLOW US

        Terms and Conditions        Privacy Policy

        Copyright © 2024 Creative BioMart. All Rights Reserved.

        Contact Us

        • /
        • Service lnquiry:

        Stay Updated on the Latest Bioscience Trends