ATP2B1

  • Official Full Name

    ATPase, Ca++ transporting, plasma membrane 1

  • Overview

    The protein encoded by this gene belongs to the family of P-type primary ion transport ATPases characterized by the formation of an aspartyl phosphate intermediate during the reaction cycle. These enzymes remove bivalent calcium ions from eukaryotic cells against very large concentration gradients and play a critical role in intracellular calcium homeostasis. The mammalian plasma membrane calcium ATPase isoforms are encoded by at least four separate genes and the diversity of these enzymes is further increased by alternative splicing of transcripts. The expression of different isoforms and splice variants is regulated in a developmental, tissue- and cell type-specific manner, suggesting that these pumps are functionally adapted to the physiological needs of particular cells and tissues. This gene encodes the plasma membrane calcium ATPase isoform 1. Alternatively spliced transcript variants encoding different isoforms have been identified.

  • Synonyms

    ATP2B1;ATPase, Ca++ transporting, plasma membrane 1;plasma membrane calcium-transporting ATPase 1;plasma membrane calcium transporting ATPase 1;PMCA1;ATPase Ca++ transporting plasma membrane 1;Plasma membrane calcium ATPase 1;Plasma membrane calcium ATPase isoform 1;Plasma membrane calcium pump isoform 1;PMCA 1;OTTHUMP00000242513;OTTHUMP00000242514;OTTHUMP00000242515;plasma membrane calcium pump;PMCA1kb

Recombinant Proteins

  • Mouse
  • Chicken
  • Rat
  • Human
  • Mammalian Cells
  • Wheat Germ
  • E.coli
  • HEK293
  • His
  • GST
  • Avi
  • Fc

    Involved Pathway

    ATP2B1 involved in several pathways and played different roles in them. We selected most pathways ATP2B1 participated on our site, such as Calcium signaling pathway,cGMP-PKG signaling pathway,cAMP signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with ATP2B1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Adrenergic signaling in cardiomyocytes MAPK3,CALM3A,ADRB2B,ADCY3,ATP2B2,CACNG8,TNNT2A,RAPGEF3,GNAI1,TPM4A
    Calcium signaling pathway ATP2A1,AGTR1B,ATP2A1L,ORAI1,GNA11,PPP3CCA,GRIN2C,PHKA2,ADRA1D,PTGER3
    cGMP-PKG signaling pathway ATP2A1,MAPK1,CREB3L1,AGTR1B,PPP1CB,ITPR1,PPP3CC,PPP1CC,PLCB4,VASP
    Pancreatic secretion PLA2G12A,PLA2G2E,PRSS2,PLA2G2A,SCTR,PRKCG,ITPR1,ATP1A2,PRKCB,AMY2A4
    cAMP signaling pathway SLC9A1,GRIN2B,RAP1A,RAF1,RAC2,HCN4,FOS,F2R,HHIP,GRIN2C
    Salivary secretion PRKACB,CALM1,PRKACA,CALM2,CST3,ATP1B2,KCNN4,CD38,LYZ1,CST1
    Endocrine and other factor-regulated calcium reabsorption DNM3,PTH1R,CALB1,ATP1A3,VDR,PRKCA,SLC8A1,KLK1B9,KLK1B24,RAB11A
    Mineral absorption STEAP1,SLC46A1,SLC26A6,FXYD2,ATP1B4,MT2A,MT1M,TF,CLCN2,ATP1A3

    Protein Function

    ATP2B1 has several biochemical functions, for example, ATP binding,PDZ domain binding,calcium-transporting ATPase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by ATP2B1 itself. We selected most functions ATP2B1 had, and list some proteins which have the same functions with ATP2B1. You can find most of the proteins on our site.

    Function Related Protein
    calmodulin binding KCNQ3,PPP3CB,RGS2,ITPKC,ADD2,EDF1,PNCK,SNTB2,RRAD,MAP2
    nucleotide binding GNAI2A,RBM22,CAMK2D2,IGF1RA,MYHZ1.1,CLK2A,PDPK1A,SMYHC1,ATP2B1A,CAMK1DB
    PDZ domain binding FZD8,Apba1,MAP2K2,PLEKHA2,USHBP1,ATP2B1A,F11R,DLC,ADAM17,TGFBR3
    protein binding SIK2,PRKD3,IFT20,DAPK2,MAGEH1,PHYH,SGOL1,NPM1,RBFOX1,TMED2
    hydrolase activity PRSS28,TDP2B,CDC14AA,CTSBB,KLK1B5,PPM1BB,Chil3,PTPRZ1,ABHD2A,PLBD1
    calcium-transporting ATPase activity ATP2A3,ATP2B2,ATP2A2,ATP2C1,ATP2B1B,ATP2B3B,ATP2B1A,ATP2A1,ATP2A2B,ATP2B3A
    metal ion binding DHX57,KLF2B,NOX1,ZMYND17,MKNK2,SP8B,MT4,NFS1,PHF23B,C6AST1
    ATP binding MOS,ITPKC,SBK3,ROS1,ATAD2B,PANK4,HLTF,EPHB3A,ABCA4,ATP9B

    Interacting Protein

    ATP2B1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ATP2B1 here. Most of them are supplied by our site. Hope this information will be useful for your research of ATP2B1.

    sec31l1_mouse_protei;Mbip;Cse1l;Tmem173

    Resources

    References

    • Ramoino, P; Milanese, M; et al. gamma-Amino butyric acid (GABA) release in the ciliated protozoon Paramecium occurs by neuronal-like exocytosis. JOURNAL OF EXPERIMENTAL BIOLOGY 213:1251-1258(2010).
    • Mangialavori, I; Giraldo, AMV; et al. A New Conformation in Sarcoplasmic Reticulum Calcium Pump and Plasma Membrane Ca2+ Pumps Revealed by a Photoactivatable Phospholipidic Probe. JOURNAL OF BIOLOGICAL CHEMISTRY 284:4823-4828(2009).

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