ATP2B1

  • Official Full Name

    ATPase, Ca++ transporting, plasma membrane 1

  • Overview

    The protein encoded by this gene belongs to the family of P-type primary ion transport ATPases characterized by the formation of an aspartyl phosphate intermediate during the reaction cycle. These enzymes remove bivalent calcium ions from eukaryotic cells against very large concentration gradients and play a critical role in intracellular calcium homeostasis. The mammalian plasma membrane calcium ATPase isoforms are encoded by at least four separate genes and the diversity of these enzymes is further increased by alternative splicing of transcripts. The expression of different isoforms and splice variants is regulated in a developmental, tissue- and cell type-specific manner, suggesting that these pumps are functionally adapted to the physiological needs of particular cells and tissues. This gene encodes the plasma membrane calcium ATPase isoform 1. Alternatively spliced transcript variants encoding different isoforms have been identified.

  • Synonyms

    ATP2B1;ATPase, Ca++ transporting, plasma membrane 1;plasma membrane calcium-transporting ATPase 1;plasma membrane calcium transporting ATPase 1;PMCA1;ATPase Ca++ transporting plasma membrane 1;Plasma membrane calcium ATPase 1;Plasma membrane calcium ATPase isoform 1;Plasma membrane calcium pump isoform 1;PMCA 1;OTTHUMP00000242513;OTTHUMP00000242514;OTTHUMP00000242515;plasma membrane calcium pump;PMCA1kb

Recombinant Proteins

  • Mouse
  • Chicken
  • Rat
  • Human
  • Mammalian Cells
  • Wheat Germ
  • E.coli
  • HEK293
  • His
  • GST
  • Avi
  • Fc

    Involved Pathway

    ATP2B1 involved in several pathways and played different roles in them. We selected most pathways ATP2B1 participated on our site, such as Calcium signaling pathway,cGMP-PKG signaling pathway,cAMP signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with ATP2B1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Endocrine and other factor-regulated calcium reabsorption PLCB3,PLCB4,SLC8A1,ATP1A1,KLK1B24,PRKACB,ESR1,DNM3,PRKACG,KLK1B11
    cGMP-PKG signaling pathway ROCK2,NFATC3,PPP1R12A,CREB3L1,PRKG2,GNAQ,NFATC2,ATP2A1,PPIF,PRKCE
    Pancreatic secretion CPA1,CTRL,RAP1B,ATP1B1,CCKAR,RAB8A,ATP1A2,RAP1A,RAC1,FXYD2
    Calcium signaling pathway CHRNA7,GNA11,GRPR,SLC25A5,PHKA1,STIM1A,DRD1B,EDNRAA,P2RX5,STIM2
    Salivary secretion NOS1,ATP1B3,PRH1,PRKG1,LYZ2,Slc4a2,VAMP2,ATP1B1,ITPR1,ATP1A1
    Mineral absorption SLC40A1,ATP1A3,SLC34A2,SLC5A1,ATP1B3,TRPM6,ATP1B4,STEAP1,STEAP2,S100G
    Adrenergic signaling in cardiomyocytes ADRB2,AKT3A,PPP1CB,MAPK3,PIK3R2,MAPK12B,CACNG1A,ATP1B2A,ADRA1B,PRKACBB
    cAMP signaling pathway MAPK3,BDNF,GRIN3A,FXYD1,PRKACG,PRKACA,CNGA2,RAF1,PLN,MAPK1

    Protein Function

    ATP2B1 has several biochemical functions, for example, ATP binding,PDZ domain binding,calcium-transporting ATPase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by ATP2B1 itself. We selected most functions ATP2B1 had, and list some proteins which have the same functions with ATP2B1. You can find most of the proteins on our site.

    Function Related Protein
    nucleotide binding CPSF6,RAP1AA,ABCA6,MCM6L,RBM28,ATAD1B,PABPN1,MYH1,ADCY2B,RHOAE
    PDZ domain binding CXXC4,BAIAP2,FZD7,SRR,FZD3,DOCK4,PTENB,SDC2,PLEKHA2,ATP2B1B
    calmodulin binding SMTNL1,SNTB1,STRN,MYO1A,SPHK1,ADCY1,GEM,CAMK1GA,PHKA2,PPP3CB
    calcium-transporting ATPase activity ATP2A1L,ATP2C1,ATP2A2A,ATP2C2,ATP2A2B,ATP2B1A,ATP2B2,ATP2B3B,ATP2B3A,ATP2A2
    hydrolase activity SPINT1A,EIF4A1A,MCM3L,GPN2,CASP3A,NOTUM1B,PSMB11,CAPN3B,CTSLL,CTSSB.2
    metal ion binding TRP63,NEK11,ADCY8,CHD4A,GNE,NUDT12,IRF2BP2B,ZNF207A,ITGA2,STK24
    ATP binding ABCF2A,CKMT2B,HKDC1,Adcy4,TIMM44,CDK9,PAK7,KIF5A,DDX39B,RPS6KA4
    protein binding CCDC110,TSN,KLC1,SERPINF2,DPH3,SLAMF1,PDZD11,CGA,TXNL4A,PLEKHO1

    Interacting Protein

    ATP2B1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ATP2B1 here. Most of them are supplied by our site. Hope this information will be useful for your research of ATP2B1.

    sec31l1_mouse_protei;Mbip;Cse1l;Tmem173

    Resources

    References

    • Ramoino, P; Milanese, M; et al. gamma-Amino butyric acid (GABA) release in the ciliated protozoon Paramecium occurs by neuronal-like exocytosis. JOURNAL OF EXPERIMENTAL BIOLOGY 213:1251-1258(2010).
    • Mangialavori, I; Giraldo, AMV; et al. A New Conformation in Sarcoplasmic Reticulum Calcium Pump and Plasma Membrane Ca2+ Pumps Revealed by a Photoactivatable Phospholipidic Probe. JOURNAL OF BIOLOGICAL CHEMISTRY 284:4823-4828(2009).

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