• Official Full Name

    ATPase, Ca++ transporting, plasma membrane 1

  • Background

    The protein encoded by this gene belongs to the family of P-type primary ion transport ATPases characterized by the formation of an aspartyl phosphate intermediate during the reaction cycle. These enzymes remove bivalent calcium ions from eukaryotic cells against very large concentration gradients and play a critical role in intracellular calcium homeostasis. The mammalian plasma membrane calcium ATPase isoforms are encoded by at least four separate genes and the diversity of these enzymes is further increased by alternative splicing of transcripts. The expression of different isoforms and splice variants is regulated in a developmental, tissue- and cell type-specific manner, suggesting that these pumps are functionally adapted to the physiological needs of particular cells and tissues. This gene encodes the plasma membrane calcium ATPase isoform 1. Alternatively spliced transcript variants encoding different isoforms have been identified.
  • Synonyms

    ATP2B1; ATPase, Ca++ transporting, plasma membrane 1; plasma membrane calcium-transporting ATPase 1; plasma membrane calcium transporting ATPase 1; PMCA1; ATPase Ca++ transporting plasma membrane 1; Plasma membrane calcium ATPase 1; Plasma membrane calcium ATPase isoform 1; Plasma membrane calcium pump isoform 1; PMCA 1; OTTHUMP00000242513; OTTHUMP00000242514; OTTHUMP00000242515; plasma membrane calcium pump; PMCA1kb;
    • Type:
    • Recombinant Proteins
    • Protein Pre-coupled Magnetic Beads
    • Species :
    • Chicken
    • Human
    • Mouse
    • Rat
    • Source :
    • E.coli
    • HEK293
    • Mammalian Cell
    • Wheat Germ
    • Tag :
    • GST
    • His
    • His (Fc)
    • Avi
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Chicken ATP2B1-4035C Recombinant Chicken ATP2B1 Mammalian Cell His
    Human ATP2B1-972H Recombinant Human ATP2B1 protein, GST-tagged Wheat Germ GST
    Mouse ATP2B1-2122M Recombinant Mouse ATP2B1 Protein Mammalian Cell His
    Mouse ATP2B1-11M Recombinant Mouse ATP2B1 Protein, His-tagged E.coli His
    Mouse ATP2B1-856M Recombinant Mouse ATP2B1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
    Mouse ATP2B1-856M-B Recombinant Mouse ATP2B1 Protein Pre-coupled Magnetic Beads HEK293
    Rat ATP2B1-517R Recombinant Rat ATP2B1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
    Rat ATP2B1-517R-B Recombinant Rat ATP2B1 Protein Pre-coupled Magnetic Beads HEK293
    Rat ATP2B1-861R Recombinant Rat ATP2B1 Protein Mammalian Cell His
    • Involved Pathway
    • Protein Function
    • Interacting Protein
    • ATP2B1 Related Articles

    ATP2B1 involved in several pathways and played different roles in them. We selected most pathways ATP2B1 participated on our site, such as Calcium signaling pathway, cGMP-PKG signaling pathway, cAMP signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with ATP2B1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    cAMP signaling pathwayHCAR2;ROCK1;NPR1;BAD;PDE4C;PPARA;GLI3;SOX9;RELA
    Adrenergic signaling in cardiomyocytesCACNA1SB;CACNG6A;ATP1B1;TNNT2;MAPK14A;PLCB2;MAPK14B;ATP2B3B;TNNC1A
    Endocrine and other factor-regulated calcium reabsorptionATP2B1;FXYD2;PRKCG;KLK1B8;ATP1A2;PRKCA;ATP1B4;TRPV5;SLC8A1
    Salivary secretionATP1B3;BST1;ATP1B2;CST5;GNAS;FXYD2;ATP2B4;PRH1;LYZ2
    Pancreatic secretionRAB8A;FXYD2;PRSS2;PRKCG;RAP1B;LOC780933;PLA2G12B;PLA2G2A;CPA3
    Mineral absorptionMT1X;TRPV6;MT1F;MT1H;FTL;MT1A;ATP1A1;MT1E;Trf

    ATP2B1 has several biochemical functions, for example, ATP binding, PDZ domain binding, calcium-transporting ATPase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by ATP2B1 itself. We selected most functions ATP2B1 had, and list some proteins which have the same functions with ATP2B1. You can find most of the proteins on our site.

    Function Related Protein
    PDZ domain bindingEXOC4;Apba1;ADAM17;ATP2B1A;SLC22A12;Fzd4;CXXC4;GRASP;GRIA1
    calcium-transporting ATPase activityATP2C2;ATP2A3;ATP2C1;ATP2B2;ATP2B1A;ATP2A1L;ATP2B3A;ATP2A2B;ATP2A1
    hydrolase activityMPPED1;ABCB1A;PLCD1A;ADAM25;PCSK5B;TMPRSS11F;F2RL1.1;TMPRSS13A;ESPL1
    metal ion bindingHMOX1A;RFK;ZFP775;DGKAA;CA14;GNAS;ZFP687;C1GALT1;PDE12
    nucleotide bindingCSNK1DA;SCAF4;RBMX;ACTA1A;UBE2D1A;TTLL13;THOC4;ATP11A;RBM4.2
    protein bindingCLCN1;ZNF187;VAV2;FANCL;UBTD1;SOCS4;GTSE1;MYH10;AEBP2

    ATP2B1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ATP2B1 here. Most of them are supplied by our site. Hope this information will be useful for your research of ATP2B1.

    sec31l1_mouse_protei; Mbip; Cse1l; Tmem173

    Ramoino, P; Milanese, M; et al. gamma-Amino butyric acid (GABA) release in the ciliated protozoon Paramecium occurs by neuronal-like exocytosis. JOURNAL OF EXPERIMENTAL BIOLOGY 213:1251-1258(2010).
    Mangialavori, I; Giraldo, AMV; et al. A New Conformation in Sarcoplasmic Reticulum Calcium Pump and Plasma Membrane Ca2+ Pumps Revealed by a Photoactivatable Phospholipidic Probe. JOURNAL OF BIOLOGICAL CHEMISTRY 284:4823-4828(2009).
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