ATP2B1
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Official Full Name
ATPase, Ca++ transporting, plasma membrane 1
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Overview
The protein encoded by this gene belongs to the family of P-type primary ion transport ATPases characterized by the formation of an aspartyl phosphate intermediate during the reaction cycle. These enzymes remove bivalent calcium ions from eukaryotic cells against very large concentration gradients and play a critical role in intracellular calcium homeostasis. The mammalian plasma membrane calcium ATPase isoforms are encoded by at least four separate genes and the diversity of these enzymes is further increased by alternative splicing of transcripts. The expression of different isoforms and splice variants is regulated in a developmental, tissue- and cell type-specific manner, suggesting that these pumps are functionally adapted to the physiological needs of particular cells and tissues. This gene encodes the plasma membrane calcium ATPase isoform 1. Alternatively spliced transcript variants encoding different isoforms have been identified. -
Synonyms
ATP2B1; ATPase, Ca++ transporting, plasma membrane 1; plasma membrane calcium-transporting ATPase 1; plasma membrane calcium transporting ATPase 1; PMCA1; ATPase Ca++ transporting plasma membrane 1; Plasma membrane calcium ATPase 1; Plasma membrane calcium ATPase isoform 1; Plasma membrane calcium pump isoform 1; PMCA 1; OTTHUMP00000242513; OTTHUMP00000242514; OTTHUMP00000242515; plasma membrane calcium pump; PMCA1kb;
- Recombinant Proteins
- Protein Pre-coupled Magnetic Beads
- Chicken
- Human
- Mouse
- Rat
- E.coli
- HEK293
- Mammalian Cell
- Wheat Germ
- GST
- His
- Fc
- Avi
| Species | Cat.# | Product name | Source (Host) | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| Human | ATP2B1-972H | Recombinant Human ATP2B1 protein, GST-tagged | Wheat Germ | GST |
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| Mouse | ATP2B1-2122M | Recombinant Mouse ATP2B1 Protein | Mammalian Cell | His |
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| Mouse | ATP2B1-11M | Recombinant Mouse ATP2B1 Protein, His-tagged | E.coli | His |
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| Mouse | ATP2B1-856M | Recombinant Mouse ATP2B1 Protein, His (Fc)-Avi-tagged | HEK293 | His&Fc&Avi |
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| Mouse | ATP2B1-856M-B | Recombinant Mouse ATP2B1 Protein Pre-coupled Magnetic Beads | HEK293 |
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| Rat | ATP2B1-861R | Recombinant Rat ATP2B1 Protein | Mammalian Cell | His |
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| Rat | ATP2B1-517R | Recombinant Rat ATP2B1 Protein, His (Fc)-Avi-tagged | HEK293 | His&Fc&Avi |
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| Rat | ATP2B1-517R-B | Recombinant Rat ATP2B1 Protein Pre-coupled Magnetic Beads | HEK293 |
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| Chicken | ATP2B1-4035C | Recombinant Chicken ATP2B1 | Mammalian Cell | His |
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- Involved Pathway
- Protein Function
- Interacting Protein
- Other Resource
ATP2B1 involved in several pathways and played different roles in them. We selected most pathways ATP2B1 participated on our site, such as Calcium signaling pathway, cGMP-PKG signaling pathway, cAMP signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with ATP2B1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Calcium signaling pathway | PDGFRB;ADRB3A;TRHR;HTR2B;DRD1;PLCB2;SLC25A4;EDNRA;PHKB |
| cGMP-PKG signaling pathway | NFATC1;BDKRB2;BNP;ATP1B4;ROCK2;IRS1;ITPR1;RGS2;Adcy4 |
| cAMP signaling pathway | NFKB1;HCAR3;BDNF;HCAR2;GRIN3A;PTCH1;ATP1A1;PAK1;ATP2B1 |
| Adrenergic signaling in cardiomyocytes | CACNA1SB;MYL4;MAPK14B;GNA11A;PIK3R3B;ADRB3B;RPS6KA5;ADRB2A;ATP1B3 |
| Endocrine and other factor-regulated calcium reabsorption | KL;PRKACG;ATP1A2;PRKCA;ATP1B3;PTH1R;PRKCB;TRPV5;KLK2 |
| Salivary secretion | CST1;PRKCB;ATP1B3;NOS1;CALML3;ATP1A4;ATP1A1;GUCY1B3;PRKCA |
| Pancreatic secretion | PLA2G2E;ITPR1;ATP1B1;SLC4A4;ATP2B4;SLC9A1;PLA2G2A;PRSS3;CLCA5 |
| Mineral absorption | SLC9A3;VDR;ATP1A3;MT1H;SLC46A1;ATP1A4;MT2;MT1A;STEAP1 |
ATP2B1 has several biochemical functions, for example, ATP binding, PDZ domain binding, calcium-transporting ATPase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by ATP2B1 itself. We selected most functions ATP2B1 had, and list some proteins which have the same functions with ATP2B1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| ATP binding | MCM2;MYO7A;RUVBL2;HSPA12A;MAP3K13;PBK;CCT3;DGKA;JAK2A |
| PDZ domain binding | USHBP1;LIN7B;SNTA1;ACCN3;LPAR1;GRASP;ATP2B3A;LNX2;SLC22A5 |
| calcium-transporting ATPase activity | ATP2B4;ATP2A1L;ATP2A2B;ATP2B1;ATP2A3;ATP2C1;ATP2B1B;ATP2A2;ATP2B2 |
| calmodulin binding | SLC9A1;CAMK2B1;TRPV1;PLCB1;CNN3A;STRN4;ADD2;KCNN2;ATP2B1 |
| hydrolase activity | IDI1;FIGNL1;ATP1A1A.4;OVCA2;HE2;G6PC3;ADAMTS7;HDAC9B;GM5136 |
| metal ion binding | ZFP143;KEL;KDM5BB;LOXL2A;ACLY;CPXCR1;ZNFL2A;DDX11;LMO7B |
| nucleotide binding | ABCA4;RBM42;SF3B4;HSPA4L;ACTB1;NT5C3L;ZRSR2;RAB5AA;MTHFSD |
| protein binding | ADAM23;RHOXF2;ZNF365;PRPSAP1;SVIL;COPB1;SUV39H1;SLC1A2;ZNRF1 |
ATP2B1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ATP2B1 here. Most of them are supplied by our site. Hope this information will be useful for your research of ATP2B1.
sec31l1_mouse_protei; Mbip; Cse1l; Tmem173
Research Area
Related articles
- Reviews
- Q&As
Customer Reviews (3)
Write a reviewThe bands of ATP2B1 in Western blot were regular in shape and showed good quality.
ATP2B1 is really amazing. It maintains a very stable performance every time it is used. You can see that its production process is very careful.
The high catalytic efficiency, safety, and expression level of this protein make it ideal for laboratory and practical applications.
Q&As (6)
Ask a questionHuman ATP2B1 recombinant protein can be administered by injection, intravenous drip, and other ways, which can be solution, powder or lyophilized powder.
Previous studies have focused on the mechanism of ATP2B1 protein in hypertension and cardiovascular disease, the correlation of polymorphism, and the relationship between ATP2B1 variation and disease susceptibility.
ATP2B1 recombinant protein may affect physiological functions such as vasoconstriction and cardiac contraction by regulating calcium transport, thereby affecting hypertension and cardiovascular diseases.
Some studies have found that the expression level of ATP2B1 gene is related to hypertension, heart disease and other diseases, but the detailed mechanism needs to be further explored and confirmed.
The evaluation of the therapeutic potential of human ATP2B1 recombinant protein mainly includes in vitro experiments, animal model studies and clinical trials.
Yes, in addition to ATP2B1, other calcium transporters (such as ATP2A1 and ATP2A2) have been found to be related to the regulation of intracellular and extracellular calcium balance.
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