ATP5C1

  • Official Full Name

    ATP synthase, H+ transporting, mitochondrial F1 complex, gamma polypeptide 1

  • Overview

    This gene encodes a subunit of mitochondrial ATP synthase. Mitochondrial ATP synthase catalyzes ATP synthesis, utilizing an electrochemical gradient of protons across the inner membrane during oxidative phosphorylation. ATP synthase is composed of two linked multi-subunit complexes: the soluble catalytic core, F1, and the membrane-spanning component, Fo, comprising the proton channel. The catalytic portion of mitochondrial ATP synthase consists of 5 different subunits (alpha, beta, gamma, delta, and epsilon) assembled with a stoichiometry of 3 alpha, 3 beta, and a single representative of the other 3. The proton channel consists of three main subunits (a, b, c). This gene encodes the gamma subunit of the catalytic core. Alternatively spliced transcript variants encoding different isoforms have been identified. This gene also has a pseudogene on chromosome 14.
  • Synonyms

    ATP5C1; ATP synthase, H+ transporting, mitochondrial F1 complex, gamma polypeptide 1; ATP5C, ATP5CL1; ATP synthase subunit gamma, mitochondrial; ATP synthase gamma chain, mitochondrial; ATP synthase, H+ transporting, mitochondrial F1 complex, gamma subunit; ATP5C 1; ATP5C; ATP5CL1; F ATPase gamma subunit; Mitochondrial ATP synthase, gamma subunit 1; F-ATPase gamma subunit;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Bovine
  • Chicken
  • Cynomolgus Monkey
  • Human
  • Rat
  • Zebrafish
  • E.coli
  • E.Coli or Yeast
  • HEK293
  • In Vitro Cell Free System
  • Mammalian Cell
  • Wheat Germ
  • GST
  • His
  • His (Fc)
  • Avi
  • Myc
  • N/A
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human ATP5C1-10016H Recombinant Human ATP5C1, GST-tagged E.coli GST 1-298a.a.
Human ATP5C1-978H Recombinant Human ATP5C1 protein, GST-tagged Wheat Germ GST
Human ATP5C1-133H Recombinant Human ATP5C1 Protein, His-tagged E.coli His
Human ATP5C1-132H Recombinant Human ATP5C1Protein, His-tagged E.coli His
Human ATP5C1-7626H Recombinant Human ATP5C1, His-tagged E.coli N/A 26-298aa
Human ATP5C1-8603HCL Recombinant Human ATP5C1 293 Cell Lysate HEK293 N/A
Human ATP5C1-8604HCL Recombinant Human ATP5C1 293 Cell Lysate HEK293 N/A
Human ATP5C1-1388HF Recombinant Full Length Human ATP5C1 Protein, GST-tagged In Vitro Cell Free System GST 298 amino acids
Human ATP5C1-1175H Recombinant Human ATP5C1 protein, His&Myc-tagged E.coli His&Myc 26-298aa
Rat Atp5c1-3722R Recombinant Rat Atp5c1, His-tagged E.Coli or Yeast His 273
Bovine ATP5C1-3723B Recombinant Bovine ATP5C1, His-tagged E.Coli or Yeast His 298
Cynomolgus Monkey ATP5C1-322C Recombinant Cynomolgus ATP5C1 Protein, His-tagged Mammalian Cell His
Cynomolgus Monkey ATP5C1-72C Recombinant Cynomolgus Monkey ATP5C1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Cynomolgus Monkey ATP5C1-72C-B Recombinant Cynomolgus Monkey ATP5C1 Protein Pre-coupled Magnetic Beads HEK293
Zebrafish ATP5C1-10396Z Recombinant Zebrafish ATP5C1 Mammalian Cell His
Chicken ATP5C1-5361C Recombinant Chicken ATP5C1 Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • Other Resource

ATP5C1 involved in several pathways and played different roles in them. We selected most pathways ATP5C1 participated on our site, such as Oxidative phosphorylation, Metabolic pathways, Alzheimers disease, which may be useful for your reference. Also, other proteins which involved in the same pathway with ATP5C1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Oxidative phosphorylationATP6V0A1B;UQCRC2B;ATP5H;NDUFS7;NDUFB5;SDHDB;ctaG;ATP5J;ATP6V0A1A
Metabolic pathwaysCOX5A;ENO2;CYP2P6;DAO.1;XYLT2;UGT1A6;NDUFA1;PRODH2;GALK1
Alzheimers diseaseCDK5;COX7B;UQCRH;SDHD;UQCRB;COX7A2L;MAPK3;UQCRQ;SDHC
Parkinsons diseaseSLC25A31;UBE2G1;PINK1;UQCR10;UCHL1;UQCRFS1;SEPT5;NDUFA6;NDUFA5
Huntingtons diseaseATP5H;SIN3A;ATP5O;COX7A1;NDUFB6;COX4I2;COX8A;NDUFB11;POLR2C

ATP5C1 has several biochemical functions, for example, contributes_to ATPase activity, poly(A) RNA binding, proton-transporting ATP synthase activity, rotational mechanism. Some of the functions are cooperated with other proteins, some of the functions could acted by ATP5C1 itself. We selected most functions ATP5C1 had, and list some proteins which have the same functions with ATP5C1. You can find most of the proteins on our site.

Function Related Protein
contributes_to ATPase activityMSH6;ATP5F1;ATP5C1;SFRP5;ATP5J2;MSH2;ATP6V1H;ATP1A2;ATP5J
poly(A) RNA bindingCDKN2A;ZFP768;PFN1;HERC5;BST2;HNRPDL;MRPL41;PAN3;TRIM25
proton-transporting ATP synthase activity, rotational mechanismATP6V0C;ATP5O;ATP5C1;ATP5B;ATP6AP1B;ATP5E;ATP6AP1;ATP5A1
proton-transporting ATPase activity, rotational mechanismATPV0E2;ATP6V0E;ATP6V0E1;ATP6V0CB;ATP6V1AA;ATP6V0A4;ATP6V0A2B;TCIRG1;ATP6V0A1A
transmembrane transporter activitySLC22A23;ATP5J;SLC22A7B.1;SLC17A9B;SLC22A1;SV2A;SLCO1D1;SV2B;SLC17A9

ATP5C1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ATP5C1 here. Most of them are supplied by our site. Hope this information will be useful for your research of ATP5C1.

MYC; VCAM1; P; ATF2; ATP5F1; CA12; NDUFB3; EGFR; SERPINA1; ITIH2; PTN; CCND3; ELOF1

Research Area

Related articles

Ding, BQ; Xi, Y; et al. Gene Expression Profiles of Entorhinal Cortex in Alzheimer's Disease. AMERICAN JOURNAL OF ALZHEIMERS DISEASE AND OTHER DEMENTIAS 29:526-532(2014).
MacLeod, G; Varmuza, S; et al. Tandem Affinity Purification in Transgenic Mouse Embryonic Stem Cells Identifies DDOST as a Novel PPP1CC2 Interacting Protein. BIOCHEMISTRY 51:9678-9688(2012).
  • Q&As
  • Reviews

Q&As (6)

Ask a question
What are the regulatory mechanisms of ATP5C1? 11/18/2021

ATP5C1 expression and function are affected by a variety of regulatory mechanisms, including regulation of transcription factors and epigenetic modifications.

Is ATP5Cexpression associated with the development of specific diseases? 10/29/2021

Yes, ATP5C1 expression levels may be associated with the development and progression of certain diseases.

In which tissues or organs is ATP5Chighly expressed? 05/23/2021

ATP5C1 is highly expressed in multiple tissues and organs, especially metabolically active tissues such as heart, liver, and brain.

Are ATP5Cgene mutations associated with nervous system diseases? 12/26/2020

Yes, ATP5C1 gene mutations are associated with certain neurological diseases such as Parkinson's disease, cerebral ischemia, etc.

Which the role of ATP5Cin tumors? 11/11/2020

It may play a role in tumor cell metabolism and energy supply.

What is the role of ATP5Cprotein in metabolic diseases? 12/19/2019

ATP5C1 protein may be related to the occurrence and progression of metabolic diseases such as obesity and diabetes.

Customer Reviews (3)

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Reviews
04/24/2022

    The exceptional stability of this protein makes it an invaluable tool for a wide range of applications.

    08/19/2021

      Due to the wide application of proteins, researchers can conduct research in more fields and broaden the horizon of scientific research.

      05/24/2019

        Because the extraordinary activity of proteins makes them valuable tools for a wide range of applications.

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