ATP6V1C2

  • Official Full Name

    ATPase, H+ transporting, lysosomal 42kDa, V1 subunit C2

  • Overview

    This gene encodes a component of vacuolar ATPase (V-ATPase), a multisubunit enzyme that mediates acidification of eukaryotic intracellular organelles. V-ATPase dependent organelle acidification is necessary for such intracellular processes as protein sorting, zymogen activation, receptor-mediated endocytosis, and synaptic vesicle proton gradient generation. V-ATPase is composed of a cytosolic V1 domain and a transmembrane V0 domain. The V1 domain consists of three A,three B, and two G subunits, as well as a C, D, E, F, and H subunit. The V1 domain contains the ATP catalytic site. This gene encodes alternate transcriptional splice variants, encoding different V1 domain C subunit isoforms.
  • Synonyms

    ATP6V1C2; ATPase, H+ transporting, lysosomal 42kDa, V1 subunit C2; ATPase, H+ transporting, lysosomal 42kD, V1 subunit C isoform 2 , ATPase, H+ transporting, lysosomal 42kDa, V1 subunit C isoform 2; V-type proton ATPase subunit C 2; ATP6C2; VMA5; ATPase H+ transporting lysosomal 42kDa V1 subunit C2; V ATPase C2 subunit; V ATPase subunit C 2; V type proton ATPase subunit C 2; V-ATPase subunit C 2; Vacuolar ATP synthase subunit C 2; Vacuolar H+ ATPase C2; Vacuolar proton pump subunit C 2; VATC2_HUMAN; VMA 5; OTTHUMP00000115522; OTTHUMP00000200400; V-ATPase C2 subunit;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Human
  • Mouse
  • Rat
  • E.coli
  • HEK293
  • In Vitro Cell Free System
  • Mammalian Cell
  • Wheat Germ
  • GST
  • His
  • His (Fc)
  • Avi
  • N/A
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human ATP6V1C2-10044H Recombinant Human ATP6V1C2, GST-tagged E.coli GST 1-381a.a.
Human ATP6V1C2-279H Recombinant Human ATP6V1C2 Protein, His-tagged E.coli His
Human ATP6V1C2-1004H Recombinant Human ATP6V1C2 protein, GST-tagged Wheat Germ GST
Human ATP6V1C2-8581HCL Recombinant Human ATP6V1C2 293 Cell Lysate HEK293 N/A
Human ATP6V1C2-1431HF Recombinant Full Length Human ATP6V1C2 Protein, GST-tagged In Vitro Cell Free System GST 381 amino acids
Mouse ATP6V1C2-2162M Recombinant Mouse ATP6V1C2 Protein Mammalian Cell His
Mouse ATP6V1C2-878M Recombinant Mouse ATP6V1C2 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse ATP6V1C2-878M-B Recombinant Mouse ATP6V1C2 Protein Pre-coupled Magnetic Beads HEK293
Rat ATP6V1C2-892R Recombinant Rat ATP6V1C2 Protein Mammalian Cell His
Rat ATP6V1C2-548R-B Recombinant Rat ATP6V1C2 Protein Pre-coupled Magnetic Beads HEK293
Rat ATP6V1C2-548R Recombinant Rat ATP6V1C2 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • Other Resource

ATP6V1C2 involved in several pathways and played different roles in them. We selected most pathways ATP6V1C2 participated on our site, such as Oxidative phosphorylation, Metabolic pathways, Phagosome, which may be useful for your reference. Also, other proteins which involved in the same pathway with ATP6V1C2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Oxidative phosphorylationCOX15;NDUFB3;ATP6V1E2;ATP5IA;ATP6AP2;ATP6V1E1B;COX7A2L;ATP5G3B;ATP6V0A1B
Metabolic pathwaysG6PCA.1;GNPDA1;ADSS;UOX;CYP4A10;mt-Atp8;POLR1C;ATP6V0E;EHHADH
PhagosomeTLR2;ATP6V0E2;MHC1UXA2;ATP6V0A2;ACTB1;ITGB3B;RAC1B;ATP6V0B;CD209
Synaptic vesicle cycleATP6V1E2;ATP6V0E1;UNC13C;STX1B;ATP6V0D2;ATP6V1F;ATP6V0C;ATP6V0A2;ATP6V1G1
Collecting duct acid secretionATP6V1E1;ATP6V1G1;ATP6V1G2;ATP6V0E;ATP6V1A;SLC4A1;ATP4A;ATP6V1B1;ATP6V1F
Vibrio cholerae infectionPRKACG;PRKACB;PLCG1;ATP6V1D;ATP6V1C1;ATP6V0A4;ATP6V0D1;ACTG1;ATP6AP1
Epithelial cell signaling in Helicobacter pylori infectionTJP1;NFKB1;CDC42;GIT1;SRC;RAC1;MAPK8;JAM2;IL-8
Rheumatoid arthritisCtsl;CD86;HLA-DMA;HLA-DQB1;ATP6AP1;TNFRSF11A;IL1B;MMP1;CD28

ATP6V1C2 has several biochemical functions, for example, hydrogen-exporting ATPase activity, phosphorylative mechanism, protein binding, protein dimerization activity. Some of the functions are cooperated with other proteins, some of the functions could acted by ATP6V1C2 itself. We selected most functions ATP6V1C2 had, and list some proteins which have the same functions with ATP6V1C2. You can find most of the proteins on our site.

Function Related Protein
hydrogen-exporting ATPase activity, phosphorylative mechanismATP6V1E2;ATP6V1G1;ATP6V0D1;ATP6V1E1;ATP6V1G3;ATP6V1C1;ATP6V1C2
protein bindingIFNGR1;FASTKD3;GLS2;GTF3C6;PRRG2;CD47;UCP3;MXD4;KIFC3
protein dimerization activityID2;NEUROG2;GRIN2A;HES6;ATP6V1C2;STK3;ZBED1;HIF1AL;OLIG1

ATP6V1C2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ATP6V1C2 here. Most of them are supplied by our site. Hope this information will be useful for your research of ATP6V1C2.

GOLGA2; q81l81_bacan; pi3p; ATP6V1G1; ATP6V1B2; ATP6V1A; MAGEA6; MRPS9; TTC9C; ECSIT

Research Area

Related articles

Ropka-Molik, K; Zukowski, K; et al. Comprehensive analysis of the whole transcriptomes from two different pig breeds using RNA-Seq method. ANIMAL GENETICS 45:674-684(2014).
Kandil, OM; Ghanem, N; et al. Transcriptional Analysis of Buffalo (Bubalus bubalis) Oocytes During In Vitro Maturation Using Bovine cDNA Microarray. REPRODUCTION IN DOMESTIC ANIMALS 45:63-74(2010).
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