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ATXN1

  • Official Full Name

    ataxin 1

  • Overview

    The autosomal dominant cerebellar ataxias (ADCA) are a heterogeneous group of neurodegenerative disorders characterized by progressive degeneration of the cerebellum, brain stem and spinal cord. Clinically, ADCA has been divided into three groups: ADCA types I-III. ADCAI is genetically heterogeneous, with five genetic loci, designated spinocerebellar ataxia (SCA) 1, 2, 3, 4 and 6, being assigned to five different chromosomes. ADCAII, which always presents with retinal degeneration (SCA7), and ADCAIII often referred to as the `pure cerebellar syndrome (SCA5), are most likely homogeneous disorders. Several SCA genes have been cloned and shown to contain CAG repeats in their coding regions. ADCA is caused by the expansion of the CAG repeats, producing an elongated polyglutamine tract in the corresponding protein. The expanded repeats are variable in size and unstable, usually increasing in size when transmitted to successive generations. The function of the ataxins is not known. This locus has been mapped to chromosome 6, and it has been determined that the diseased allele contains 41-81 CAG repeats, compared to 6-39 in the normal allele, and is associated with spinocerebellar ataxia type 1 (SCA1). At least two transcript variants encoding the same protein have been found for this gene. Encodes a homolog of trithorax, a histone-lysine N-methyltransferase. Involved in trimethylating histone H3-lysine 4. Involved in the formation, placement, and identity of flower organs. Role in regulation of homeotic genes. Functions as a receptor of phosphatidylinositol 5-phosphate. Localizes to cytoplasm, plasma membrane and nuclei, shifting to nuclei in the presence of PI5P.
  • Synonyms

    ATXN1; ataxin 1; SCA1, spinocerebellar ataxia 1 (olivopontocerebellar ataxia 1, autosomal dominant, ataxin 1); ataxin-1; ATX1; D6S504E; ATX1_HUMAN; OTTHUMP00000016065; SCA1; Spinocerebellar ataxia type 1 protein; Atx1p; YNL259C;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Human
  • Mouse
  • Rat
  • Yeast
  • E.coli
  • E.Coli or Yeast
  • HEK293
  • HEK293T
  • Mammalian Cell
  • Mammalian cells
  • Wheat Germ
  • C
  • Myc
  • DDK
  • Flag
  • GST
  • His
  • His (Fc)
  • Avi
  • His|T7
  • Myc|DDK
  • N/A
  • N
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human ATXN1-392H Recombinant Human ATXN1 protein, MYC/DDK-tagged HEK293 Myc/DDK
Human ATXN1-3683H Recombinant Human ATXN1 protein, His/T7-tagged E.coli His/T7 Thr569~Ile807
Human ATXN1-1029H Recombinant Human ATXN1 protein, GST-tagged Wheat Germ GST
Human ATXN1-8566HCL Recombinant Human ATXN1 293 Cell Lysate HEK293 N/A
Human ATXN1-1994H Recombinant Human ATXN1 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human ATXN1-409H Recombinant Human ATXN1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Human ATXN1-372HFL Recombinant Full Length Human ATXN1 Protein, C-Flag-tagged Mammalian cells Flag
Human ATXN1-163H Recombinant Human ATXN1 Protein, MYC/DDK-tagged, C13 and N15-labeled HEK293 C-Myc/DDK
Human ATXN1-409H-B Recombinant Human ATXN1 Protein Pre-coupled Magnetic Beads HEK293
Human ATXN1-0721H Recombinant Human ATXN1 Protein (Thr569-Ile807), N-His tagged E.coli N-His Thr569-Ile807
Mouse Atxn1-3684M Recombinant Mouse Atxn1, His-tagged E.Coli or Yeast His 791
Mouse ATXN1-2192M Recombinant Mouse ATXN1 Protein Mammalian Cell His
Mouse Atxn1-2718M Recombinant Mouse Atxn1 protein, His & T7-tagged E.coli His/T7 Pro331~Asp587 (Accession # P54254)
Mouse ATXN1-899M Recombinant Mouse ATXN1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse Atxn1-1782M Recombinant Mouse Atxn1 Protein, Myc/DDK-tagged HEK293T Myc/DDK
Mouse ATXN1-899M-B Recombinant Mouse ATXN1 Protein Pre-coupled Magnetic Beads HEK293
Rat ATXN1-900R Recombinant Rat ATXN1 Protein Mammalian Cell His
Rat ATXN1-556R Recombinant Rat ATXN1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat ATXN1-556R-B Recombinant Rat ATXN1 Protein Pre-coupled Magnetic Beads HEK293
Rat Atxn1-6853R Recombinant Rat Atxn1 Protein (Thr543-Ile781), N-His tagged E.coli N-His Thr543-Ile781
Yeast ATX1-438S Recombinant S.cervisiae Atx1p E.coli N/A
  • Involved Pathway
  • Protein Function
  • Interacting Protein

ATXN1 involved in several pathways and played different roles in them. We selected most pathways ATXN1 participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with ATXN1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein

ATXN1 has several biochemical functions, for example, protein binding, structural constituent of cytoskeleton, structural constituent of eye lens. Some of the functions are cooperated with other proteins, some of the functions could acted by ATXN1 itself. We selected most functions ATXN1 had, and list some proteins which have the same functions with ATXN1. You can find most of the proteins on our site.

Function Related Protein
protein bindingSPEG;TMSB4X;NRADD;SOCS2;FBXO11;MUC7;TMEM139;BAZ1A;SPRED1
structural constituent of cytoskeletonSORBS3;COX4I2;BFSP1;TUBA3E;TUBA1C;TUBA1L;TUBA3C;CYLC2;TUBA1L2
structural constituent of eye lensCRYABB;CRYBB2;LIM2;CRYBB1;CRYABA;CRYBB3;LIM2.2;CRYAB;BFSP2

ATXN1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ATXN1 here. Most of them are supplied by our site. Hope this information will be useful for your research of ATXN1.

RBFOX2; YWHAE; YWHAZ

  • Q&As
  • Reviews

Q&As (6)

Ask a question
How do mutations in ATXNprotein cause SCA1? 02/26/2021

SCA1 is caused by mutations in the ATXN1 gene. The mutation resulted in the expansion of glutamine repeats in ATXN1 protein, resulting in the formation of abnormal polyglutamic acid protein. This protein abnormality can lead to abnormal neuronal function and degenerative changes, leading to the occurrence of SCA1.

Does ATXNprotein interact with other proteins? 02/07/2021

Yes, the ATXN1 protein interacts with multiple proteins to form complexes involved in the regulation of a variety of cellular functions. For example, ATXN1 interacts with the Capicua (CIC) protein and is involved in transcriptional regulation.

Which diseases are associated with ATXNprotein? 04/16/2020

The protein is associated with spinocerebellar ataxia type 1 (SCA1). SCA1 is an inherited neurodegenerative disease characterized by dysfunction of the cerebellum and spinal cord, leading to ataxia and other neurological symptoms.

In which tissues is ATXNprotein expressed? 10/28/2019

ATXN1 protein is expressed in several tissues, but its expression is higher in the central nervous system, especially in the cerebellum and spinal cord.

What is the regulatory mechanism of ATXNprotein function? 06/13/2019

The function of ATXN1 protein is regulated by a variety of regulatory mechanisms, including post-translational modification, assembly of protein complexes, and transcriptional regulation. These regulatory mechanisms ensure the adaptability and stability of ATXN1 protein.

What is the role of ATXNprotein in humans? 02/05/2019

ATXN1 protein is involved in the regulation of a variety of neural cell functions, including cell cycle regulation, DNA repair, transcription regulation, etc. It plays an important role in the development and functional maintenance of the nervous system.

Customer Reviews (3)

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Reviews
12/10/2020

    Using Atxn1 as a catalyst, the rate and yield of chemical reactions can be significantly increased, and the catalytic efficiency is very high.

    10/22/2019

      The stability of Atxn1 is very good, and its structure and function remain stable even after several freeze-thaw cycles, which shows its excellent quality control and production process.

      06/18/2019

        Atxn1 are so simple to prepare that we can easily prepare them ourselves.

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