ATXN3L
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Official Full Name
ATXN3L ataxin 3-like [ Homo sapiens ]
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Overview
This intronless gene may be a pseudogene (PMID:11450850). This gene is similar to the multi-exon gene which encodes ataxin 3 and contains a coding region which could encode a protein similar to ataxin 3. Mutations in the gene encoding ataxin 3 are associated with Machado-Joseph disease. -
Synonyms
ataxin 3-like; ATX3L; MJDL; EC 3.4.19.12; Machado-Joseph disease protein 1-like; EC 3.4.22; putative ataxin-3-like protein;
- Recombinant Proteins
- Human
- E.coli
- Insect Cell
- Flag
- GST
- His
Species | Cat.# | Product name | Source (Host) | Tag | Protein Length | Price |
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Human | ATXN3L-203H | Active Recombinant Human ATXN3L protein, His-tagged | Insect Cell | His | ||
Human | ATXN3L-174H | Active Recombinant Human ATXN3L, His-tagged | E.coli | His | ||
Human | ATXN3L-10070H | Recombinant Human ATXN3L, GST-tagged | E.coli | GST | 271-341a.a. | |
Human | ATXN3L-164H | Recombinant Human ATXN3L, His-tagged | E.coli | His | ||
Human | ATXN3L-0373H | Recombinant Human ATXN3L Protein (D2-K355), Flag tagged | Insect Cell | Flag | D2-K355 | |
Human | ATXN3L-0374H | Recombinant Human ATXN3L Protein (D2-K355), His/Flag tagged | Insect Cell | His/Flag | D2-K355 |
- Involved Pathway
- Protein Function
- Interacting Protein
ATXN3L involved in several pathways and played different roles in them. We selected most pathways ATXN3L participated on our site, such as Protein processing in endoplasmic reticulum, which may be useful for your reference. Also, other proteins which involved in the same pathway with ATXN3L were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name | Pathway Related Protein |
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Protein processing in endoplasmic reticulum | SEC31A;CAPN1B;SAR1AB;SEC23B;P4HB;UBE4B;CUL1A;MARCH6;FBXO6 |
ATXN3L has several biochemical functions, for example, RNA polymerase II regulatory region DNA binding, histone deacetylase activity, omega peptidase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by ATXN3L itself. We selected most functions ATXN3L had, and list some proteins which have the same functions with ATXN3L. You can find most of the proteins on our site.
Function | Related Protein |
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RNA polymerase II regulatory region DNA binding | PPARG;NKX2-1;NCOA1;ATXN3L;TXK;NPAS4 |
histone deacetylase activity | HDAC9B;HDAC11;HDAC4;HDAC5;HDAC9;HDAC8;NACC2;HDAC3;SIRT1 |
omega peptidase activity | UCHL5;JOSD1;GGH;ATXN3;USP5;ATXN3L;UCHL1;USP13;JOSD2 |
ubiquitin-specific protease activity | ZRANB1;USP12A;USP4;USP7;USP22;USP13;DUB1;BRCC3;FMNL3 |
ATXN3L has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ATXN3L here. Most of them are supplied by our site. Hope this information will be useful for your research of ATXN3L.
- Q&As
- Reviews
Q&As (6)
Ask a questionATXN3L protein interacts with multiple proteins, including heat shock proteins, ubiquitin ligases and other regulatory proteins.
The expression and function of ATXN3L protein are affected by multiple regulatory mechanisms, including transcriptional regulation, post-translational modification, and protein-protein interaction.
The protein plays a role in regulating protein degradation in cells, and participates in the process of cell quality control and waste protein degradation.
This protein is associated with nervous system related diseases, including Parkinson's disease, Alzheimer's disease and so on.
The ATXN3L protein contains multiple functional domains, including multiple polyglutamic acid repeats, which may be involved in protein interactions and regulation of function.
ATXN3L protein is expressed in various tissues of the human body, but its expression is higher in the central nervous system.
Customer Reviews (3)
Write a reviewUnmatched reproducibility of ATXN3L, with consistent results from experiment to experiment or application, makes it ideal for use in experiments or applications that require a high degree of reproducibility.
This production process of ATXN3L is very environmentally friendly, without any harmful by-products and without any negative impact on the environment.
The short half-life and high clearance properties of this recombinant protein make it a higher potential in drug development and is expected to become a new generation of therapeutic drugs.
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