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ATXN3L

  • Official Full Name

    ATXN3L ataxin 3-like [ Homo sapiens ]

  • Overview

    This intronless gene may be a pseudogene (PMID:11450850). This gene is similar to the multi-exon gene which encodes ataxin 3 and contains a coding region which could encode a protein similar to ataxin 3. Mutations in the gene encoding ataxin 3 are associated with Machado-Joseph disease.
  • Synonyms

    ataxin 3-like; ATX3L; MJDL; EC 3.4.19.12; Machado-Joseph disease protein 1-like; EC 3.4.22; putative ataxin-3-like protein;

  • Recombinant Proteins
  • Human
  • E.coli
  • Insect Cell
  • Flag
  • GST
  • His
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human ATXN3L-203H Active Recombinant Human ATXN3L protein, His-tagged Insect Cell His
Human ATXN3L-174H Active Recombinant Human ATXN3L, His-tagged E.coli His
Human ATXN3L-10070H Recombinant Human ATXN3L, GST-tagged E.coli GST 271-341a.a.
Human ATXN3L-164H Recombinant Human ATXN3L, His-tagged E.coli His
Human ATXN3L-0373H Recombinant Human ATXN3L Protein (D2-K355), Flag tagged Insect Cell Flag D2-K355
Human ATXN3L-0374H Recombinant Human ATXN3L Protein (D2-K355), His/Flag tagged Insect Cell His/Flag D2-K355
  • Involved Pathway
  • Protein Function
  • Interacting Protein

ATXN3L involved in several pathways and played different roles in them. We selected most pathways ATXN3L participated on our site, such as Protein processing in endoplasmic reticulum, which may be useful for your reference. Also, other proteins which involved in the same pathway with ATXN3L were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Protein processing in endoplasmic reticulumSEC31A;CAPN1B;SAR1AB;SEC23B;P4HB;UBE4B;CUL1A;MARCH6;FBXO6

ATXN3L has several biochemical functions, for example, RNA polymerase II regulatory region DNA binding, histone deacetylase activity, omega peptidase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by ATXN3L itself. We selected most functions ATXN3L had, and list some proteins which have the same functions with ATXN3L. You can find most of the proteins on our site.

Function Related Protein
RNA polymerase II regulatory region DNA bindingPPARG;NKX2-1;NCOA1;ATXN3L;TXK;NPAS4
histone deacetylase activityHDAC9B;HDAC11;HDAC4;HDAC5;HDAC9;HDAC8;NACC2;HDAC3;SIRT1
omega peptidase activityUCHL5;JOSD1;GGH;ATXN3;USP5;ATXN3L;UCHL1;USP13;JOSD2
ubiquitin-specific protease activityZRANB1;USP12A;USP4;USP7;USP22;USP13;DUB1;BRCC3;FMNL3

ATXN3L has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ATXN3L here. Most of them are supplied by our site. Hope this information will be useful for your research of ATXN3L.

  • Q&As
  • Reviews

Q&As (6)

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How does the ATXN3L protein interact with other proteins? 11/26/2022

ATXN3L protein interacts with multiple proteins, including heat shock proteins, ubiquitin ligases and other regulatory proteins.

What is the regulatory mechanism of ATXN3L protein? 05/12/2022

The expression and function of ATXN3L protein are affected by multiple regulatory mechanisms, including transcriptional regulation, post-translational modification, and protein-protein interaction.

What is the function of ATXN3L protein? 07/19/2021

The protein plays a role in regulating protein degradation in cells, and participates in the process of cell quality control and waste protein degradation.

What diseases is ATXN3L involved in? 07/04/2021

This protein is associated with nervous system related diseases, including Parkinson's disease, Alzheimer's disease and so on.

What are the structural features of ATXN3L protein? 07/11/2020

The ATXN3L protein contains multiple functional domains, including multiple polyglutamic acid repeats, which may be involved in protein interactions and regulation of function.

How is ATXN3L protein expressed? 01/24/2019

ATXN3L protein is expressed in various tissues of the human body, but its expression is higher in the central nervous system.

Customer Reviews (3)

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Reviews
07/10/2021

    Unmatched reproducibility of ATXN3L, with consistent results from experiment to experiment or application, makes it ideal for use in experiments or applications that require a high degree of reproducibility.

    04/20/2021

      This production process of ATXN3L is very environmentally friendly, without any harmful by-products and without any negative impact on the environment.

      02/09/2019

        The short half-life and high clearance properties of this recombinant protein make it a higher potential in drug development and is expected to become a new generation of therapeutic drugs.

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