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Official Full Name beta-1,3-glucuronyltransferase 3 (glucuronosyltransferase I)
Background The protein encoded by this gene is a member of the glucuronyltransferase gene family, enzymes that exhibit strict acceptor specificity, recognizing nonreducing terminal sugars and their anomeric linkages. This gene product catalyzes the formation of the glycosaminoglycan-protein linkage by way of a glucuronyl transfer reaction in the final step of the biosynthesis of the linkage region of proteoglycans.
Synonyms B3GAT3; beta-1,3-glucuronyltransferase 3 (glucuronosyltransferase I); galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase 3; GlcAT I; Beta 1,3 glucuronyltransferase 3; EC; Galactosylgalactosylxylosylprotein 3 beta glucuronosyltransferase 3; GLCATI; GlcUATI; Glucuronosyltransferase I; Sqv 8 like protein; UDP GlcUA:Gal beta 1,3 GalR glucuronyltransferase; glcUAT-I; OTTHUMP00000236456; OTTHUMP00000236457; OTTHUMP00000236459; Sqv-8-like protein; UDP-GlcUA:Gal beta-1,3-Gal-R glucuronyltransferase
    • Species :
    • Human
    • Mouse
    • Zebrafish
    • Source :
    • E.coli
    • HEK293
    • HEK293T
    • Mammalian Cell
    • Wheat Germ
    • Tag :
    • GST
    • His
    • Met
    • Myc/DDK
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human B3GAT3-016H Recombinant Human B3GAT3 protein, GST-tagged Wheat Germ GST
    Human B3GAT3-017H Recombinant Human B3GAT3 protein, GST-tagged Wheat Germ GST
    Human B3GAT3-1064H Recombinant Human B3GAT3 Protein, Met & His-tagged E.coli Met/His
    Human B3GAT3-228H Recombinant Human B3GAT3 protein, His-tagged E.coli His
    Human B3GAT3-2373H Recombinant Human B3GAT3 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
    Human B3GAT3-7603H Recombinant Human B3GAT3, His-tagged E.coli N/A
    Human B3GAT3-8545HCL Recombinant Human B3GAT3 293 Cell Lysate HEK293 N/A
    Mouse B3gat3-1801M Recombinant Mouse B3gat3 Protein, Myc/DDK-tagged HEK293T Myc/DDK
    Mouse B3GAT3-2238M Recombinant Mouse B3GAT3 Protein Mammalian Cell His
    Zebrafish B3GAT3-2304Z Recombinant Zebrafish B3GAT3 Mammalian Cell His

    B3GAT3 involved in several pathways and played different roles in them. We selected most pathways B3GAT3 participated on our site, such as Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate, Glycosaminoglycan biosynthesis - heparan sulfate / heparin, Metabolic pathways, which may be useful for your reference. Also, other proteins which involved in the same pathway with B3GAT3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate CHSY3; CHST12A; CHST3; B3GAT3; CHST3A; XYLT2; CSGALNACT1; CHPF; CHST12; UST
    Glycosaminoglycan biosynthesis - heparan sulfate / heparin B4GALT7; B3GAT3; HS3ST3B1; EXT1B; EXTL1; HS6ST2; HS6ST3B; HS2ST1A; XYLT1; NDST3
    Metabolic pathways NT5C2A; NAT8L; AMY2B; NME4; ADSSL; IMPDH1; PIGU; GGPS1; DBH; BCO1

    B3GAT3 has several biochemical functions, for example, galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase activity, glucuronosyltransferase activity, metal ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by B3GAT3 itself. We selected most functions B3GAT3 had, and list some proteins which have the same functions with B3GAT3. You can find most of the proteins on our site.

    Function Related Protein
    galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase activity B3GAT1A; B3GAT1; B3GAT2; B3GAT3
    glucuronosyltransferase activity UGT1AB; UGT5D1; UGT5A5; UGT5B4; UGT1A6A; CSGALNACT1; UGT2A6; UGT2A3; UGT1A9; UGT2B1
    metal ion binding NEK9; ZSCAN12; NEK11; RARGB; BAK1; MIPEP; NENF; ZNF274; ENDOU2; RASA4
    protein binding TDP2; TSSK2; PC; NRBF2; KCNE2; RPL39L; RPA2; MCM10; SIX3; SHC4
    protein phosphatase activator activity B3GAT3; CALM; CALM1; CALM3; CALM2

    B3GAT3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with B3GAT3 here. Most of them are supplied by our site. Hope this information will be useful for your research of B3GAT3.

    SEC22B; 1-phosphatidyl-1d-myo-inositol 3,4,5-trisphosphate

    Gogate, SS; Nasser, R; et al. Hypoxic Regulation of beta-1,3-Glucuronyltransferase 1 Expression in Nucleus Pulposus Cells of the Rat Intervertebral Disc Role of Hypoxia-Inducible Factor Proteins. ARTHRITIS AND RHEUMATISM 63:1950-1960(2011).
    Negishi, M; Dong, J; et al. Glucosaminylglycan biosynthesis: what we can learn from the X-ray crystal structures of glycosyltransferases GlcAT1 and EXTL2. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 303:393-398(2003).

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