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Official Full Name UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 4
Background This gene is one of seven beta-1,4-galactosyltransferase (beta4GalT) genes. They encode type II membrane-bound glycoproteins that appear to have exclusive specificity for the donor substrate UDP-galactose; all transfer galactose in a beta1,4 linkage to similar acceptor sugars: GlcNAc, Glc, and Xyl. Each beta4GalT has a distinct function in the biosynthesis of different glycoconjugates and saccharide structures. As type II membrane proteins, they have an N-terminal hydrophobic signal sequence that directs the protein to the Golgi apparatus and which then remains uncleaved to function as a transmembrane anchor. By sequence similarity, the beta4GalTs form four groups: beta4GalT1 and beta4GalT2, beta4GalT3 and beta4GalT4, beta4GalT5 and beta4GalT6, and beta4GalT7. The enzyme encoded by this gene appears to mainly play a role in glycolipid biosynthesis. Two alternatively spliced transcript variants have been found for this gene.
Synonyms B4GALT4; UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 4; beta-1,4-galactosyltransferase 4; beta4Gal T4; B4Gal T4; Beta 1 4 galactosyltransferase 4; Beta 1 4 GalTase 4; Beta N acetylglucosaminyl glycolipid beta 1 4 galactosyltransferase 4; EC 2.4.1.-; UDP Gal:betaGlcNAc beta,4 galactosyltransferase 4; UDP Gal:betaGlcNAc beta 1 4 galactosyltransferase polypeptide 4; UDP galactose:beta N acetylglucosamine beta 1 4 galactosyltransferase 4; beta-1,4-GalTase 4; UDP-Gal:beta-GlcNAc beta-1,4-galactosyltransferase 4; UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase 4; beta-N-acetylglucosaminyl-glycolipid beta-1,4-galactosyltransferase 4; UDP-galactose:beta-N-acetylglucosamine beta-1,4-galactosyltransferase 4; B4Gal-T4; beta4Gal-T4
    • Species :
    • Human
    • Mouse
    • Rat
    • Rhesus Macaque
    • Zebrafish
    • Source :
    • E.coli
    • HEK293
    • HEK293T
    • Mammalian Cell
    • Wheat Germ
    • Tag :
    • GST
    • His
    • Myc/DDK
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human B4GALT4-031H Recombinant Human B4GALT4 protein, GST-tagged Wheat Germ GST
    Human B4GALT4-2643H Recombinant Human B4GALT4 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
    Human B4GALT4-27423TH Recombinant Human B4GALT4, His-tagged E.coli His
    Human B4GALT4-392H Recombinant Human B4GALT4 protein, His-tagged HEK293 His
    Human B4GALT4-8537HCL Recombinant Human B4GALT4 293 Cell Lysate HEK293 N/A
    Mouse B4galt4-06HCL Recombinant Mouse B4galt4 overexpression lysate HEK293T Myc/DDK
    Mouse B4galt4-1809M Recombinant Mouse B4galt4 Protein, Myc/DDK-tagged HEK293T Myc/DDK
    Mouse B4galt4-20HCL Recombinant Mouse B4galt4 overexpression lysate HEK293T Myc/DDK
    Rat B4GALT4-922R Recombinant Rat B4GALT4 Protein Mammalian Cell His
    Rhesus Macaque B4GALT4-497R Recombinant Rhesus monkey B4GALT4 Protein, His-tagged Mammalian Cell His
    Zebrafish B4GALT4-1785Z Recombinant Zebrafish B4GALT4 Mammalian Cell His

    b4galt4 involved in several pathways and played different roles in them. We selected most pathways b4galt4 participated on our site, such as Glycosaminoglycan biosynthesis - keratan sulfate, Glycosphingolipid biosynthesis - lacto and neolacto series, Metabolic pathways, which may be useful for your reference. Also, other proteins which involved in the same pathway with b4galt4 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Glycosaminoglycan biosynthesis - keratan sulfate ST3GAL2; CHST6; B3GNT7; CHST1; B3GNT1; CHST2; FUT8A; ST3GAL3; ST3GAL1; Chst5
    Glycosphingolipid biosynthesis - lacto and neolacto series B3GNT5A; B3GALT1; ST3GAL3; B3GALT5; B3GNT2; B3GNT1; FUT3; GCNT2; B4GALT2; ST3GAL3B
    Metabolic pathways PANK2; ACAA2; PIGK; LDHAL6A; ADC; NDUFB11; MSMO1; ADPGK; CYP21A2; ALOX5A

    b4galt4 has several biochemical functions, for example, N-acetyllactosamine synthase activity, galactosyltransferase activity, metal ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by b4galt4 itself. We selected most functions b4galt4 had, and list some proteins which have the same functions with b4galt4. You can find most of the proteins on our site.

    Function Related Protein
    N-acetyllactosamine synthase activity B4GALT1; B4GALT3; B4GALT2; B4GALT4
    galactosyltransferase activity A4GALT; GALNTL4; DPY19L1; B3GNTL1; B3GNT2B; B4GALT4; B3GNT5B; B4GALT5; B3GNT8; B4GALT2
    metal ion binding GUCY1B3; RFNG; VPS18; ZNF358; RARAB; RXRAA; Car9; NT5C2A; CTDSP2; WT1A

    b4galt4 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with b4galt4 here. Most of them are supplied by our site. Hope this information will be useful for your research of b4galt4.

    Psmb5; Tubg1

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