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Official Full Name xylosylprotein beta1,4-galactosyltransferase, polypeptide 7 (galactosyltransferase I)
Background Beta-1,4-galactosyltransferase 1 is an enzyme that in humans is encoded by the B4GALT1 gene. This gene is one of seven beta-1,4-galactosyltransferase (beta4GalT) genes. They encode type II membrane-bound glycoproteins that appear to have exclusive specificity for the donor substrate UDP-galactose; all transfer galactose in a beta1,4 linkage to similar acceptor sugars: GlcNAc, Glc, and Xyl. Each beta4GalT has a distinct function in the biosynthesis of different glycoconjugates and saccharide structures. As type II membrane proteins, they have an N-terminal hydrophobic signal sequence that directs the protein to the Golgi apparatus and which then remains uncleaved to function as a transmembrane anchor. By sequence similarity, the beta4GalTs form four groups: beta4GalT1 and beta4GalT2, beta4GalT3 and beta4GalT4, beta4GalT5 and beta4GalT6, and beta4GalT7. This gene is unique among the beta4GalT genes because it encodes an enzyme that participates both in glycoconjugate and lactose biosynthesis. For the first activity, the enzyme adds galactose to N-acetylglucosamine residues that are either monosaccharides or the nonreducing ends of glycoprotein carbohydrate chains. The second activity is restricted to lactating mammary tissues where the enzyme forms a heterodimer with alpha-lactalbumin to catalyze UDP-galactose + D-glucose <=> UDP + lactose. The two enzymatic forms result from alternate transcription initiation sites and post-translational processing. Two transcripts, which differ only at the 5' end, with approximate lengths of 4.1 kb and 3.9 kb encode the same protein. The longer transcript encodes the type II membrane-bound, trans-Golgi resident protein involved in glycoconjugate biosynthesis. The shorter transcript encodes a protein which is cleaved to form the soluble lactose synthase.
Synonyms B4galt7; xylosylprotein beta1,4-galactosyltransferase, polypeptide 7 (galactosyltransferase I); EDSP1; XGPT1; XGALT1; B4GALT7; xylosylprotein beta 1,4-galactosyltransferase, polypeptide 7
    • Species :
    • Chicken
    • Human
    • Mouse
    • Rhesus Macaque
    • Zebrafish
    • Source :
    • HEK293
    • HEK293T
    • Mammalian Cell
    • Wheat Germ
    • Tag :
    • GST
    • His
    • Myc/DDK
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human B4GALT7-035H Recombinant Human B4GALT7 protein, GST-tagged Wheat Germ GST
    Human B4GALT7-5141H Recombinant Human B4GALT7 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
    Human B4GALT7-8536HCL Recombinant Human B4GALT7 293 Cell Lysate HEK293 N/A
    Mouse B4galt7-08HCL Recombinant Mouse B4galt7 overexpression lysate HEK293T Myc/DDK
    Mouse B4galt7-1812M Recombinant Mouse B4galt7 Protein, Myc/DDK-tagged HEK293T Myc/DDK
    Mouse B4galt7-19HCL Recombinant Mouse B4galt7 overexpression lysate HEK293T Myc/DDK
    Rhesus Macaque B4GALT7-499R Recombinant Rhesus monkey B4GALT7 Protein, His-tagged Mammalian Cell His
    Chicken B4GALT7-3402C Recombinant Chicken B4GALT7 Mammalian Cell His
    Zebrafish B4GALT7-870Z Recombinant Zebrafish B4GALT7 Mammalian Cell His

    b4galt7 involved in several pathways and played different roles in them. We selected most pathways b4galt7 participated on our site, such as A tetrasaccharide linker sequence is required for GAG synthesis, Chondroitin sulfate/dermatan sulfate metabolism, Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate, which may be useful for your reference. Also, other proteins which involved in the same pathway with b4galt7 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    A tetrasaccharide linker sequence is required for GAG synthesis VCAN; GPC1B; B4GALT7; Gpc2; CSPG4; BGN; GPC1A; AGRN; CSPG5; BCAN
    Chondroitin sulfate/dermatan sulfate metabolism BCAN; DCN; UST; CHST14; BGNB; CSPG4; B3GAT2; CHST9; NCAN; VCANB
    Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate CHST3B; CHST3; CHSY3; UST; CHST3A; CHST12; CHST15; B3GAT3; CSGALNACT1; XYLT1
    Glycosaminoglycan biosynthesis - heparan sulfate / heparin EXT2; NDST2; GLCEB; XYLT1; B3GAT3; NDST3; HS6ST1; EXTL1; HS3ST3B1B; HS3ST3A1
    Glycosaminoglycan metabolism B3GAT2; FMODA; VCANB; B3GNT1; BGNB; OGN; ST3GAL3A; CHP; DSEL; B4GALT7
    Heparan sulfate/heparin (HS-GAG) metabolism GPC1B; CSPG5B; GPC1A; B4GALT7; HS3ST6; Gpc2; B3GAT2; HS3ST4; GPC5A; HPSE
    Metabolic pathways OXSM; CYP2J2; MCEE; PLD2; DGKAA; ACSL5; ACOT2; CYP21A2; GAMT; UOX

    b4galt7 has several biochemical functions, for example, beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase activity, galactosyltransferase activity, manganese ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by b4galt7 itself. We selected most functions b4galt7 had, and list some proteins which have the same functions with b4galt7. You can find most of the proteins on our site.

    Function Related Protein
    beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase activity B4GALT2; B4GALT7; WDFY3; B4GALT3; B4GALT1
    galactosyltransferase activity B4GALT2; DPY19L1; POC1BL; B3GNT7; B4GALT1; B4GALT7; B3GNT3; GALNT18A; GTDC2; B3GNT6
    manganese ion binding PPM1NB; NUDT7; XPNPEP3; SLC11A2; ABL1; ME1; PEPD; WRN; IMPA1; PPM1BA
    protein binding INO80E; DKK1B; HPSE; ADAMTS5; KIF7; BLOC1S2; ISOC1; STX1A; ZNF511; GTF3C5
    xylosylprotein 4-beta-galactosyltransferase activity B4GALT7

    b4galt7 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with b4galt7 here. Most of them are supplied by our site. Hope this information will be useful for your research of b4galt7.

    RABGGTB; KRTAP10-7; Cep152; MYC; GBA; PCNA; EZR; ID1; YWHAZ; CDC16; Iffo2; THOC1; PEO1

    Cartault, F; Munier, P; et al. Expanding the clinical spectrum of B4GALT7 deficiency: homozygous p.R270C mutation with founder effect causes Larsen of Reunion Island syndrome. EUROPEAN JOURNAL OF HUMAN GENETICS 23:49-53(2015).
    von Oettingen, JE; Tan, WH; et al. Skeletal dysplasia, global developmental delay, and multiple congenital anomalies in a 5-year-old boy-Report of the second family with B3GAT3 mutation and expansion of the phenotype. AMERICAN JOURNAL OF MEDICAL GENETICS PART A 164:1580-1586(2014).

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