| Description : |
This gene is one of seven beta-1,4-galactosyltransferase (beta4GalT) genes. They encode type II membrane-bound glycoproteins that appear to have exclusive specificity for the donor substrate UDP-galactose; all transfer galactose in a beta1,4 linkage to similar acceptor sugars: GlcNAc, Glc, and Xyl. Each beta4GalT has a distinct function in the biosynthesis of different glycoconjugates and saccharide structures. As type II membrane proteins, they have an N-terminal hydrophobic signal sequence that directs the protein to the Golgi apparatus and which then remains uncleaved to function as a transmembrane anchor. By sequence similarity, the beta4GalTs form four groups: beta4GalT1 and beta4GalT2, beta4GalT3 and beta4GalT4, beta4GalT5 and beta4GalT6, and beta4GalT7. The enzyme encoded by this gene attaches the first galactose in the common carbohydrate-protein (GlcA-beta1,3-Gal-beta1,3-Gal-beta1,4-Xyl-beta1-O-Ser) linkage found in proteoglycans. Manganese is required as a cofactor. This enzyme differs from the other six beta4GalTs because it lacks the conserved beta4GalT1-beta4GalT6 Cys residues and it is located in cis-Golgi instead of trans-Golgi. Two single-nucleotide mutations were identified from a patient with the progeroid type of Ehlers-Danlos syndrome. [provided by RefSeq |
| Source : |
Wheat Germ |
| Species : |
Human |
| Tag : |
GST |
| Form : |
50 mM Tris-HCI, 10 mM reduced Glutathione, pH=8.0 in the elution buffer. |
| Molecular Mass : |
63.8 kDa |
| AA Sequence : |
MFPSRRKAAQLPWEDGRSGLLSGGL PRKCSVFHLFVACLSLGFFSLLWLQ LSCSGDVARAVRGQGQETSGPPRAC PPEPPPEHWEEDASWGPHRLAVLVP FRERFEELLVFVPHMRRFLSRKKIR HHIYVLNQVDHFRFNRAALINVGFL ESSNSTDYIAMHDVDLLPLNEELDY GFPEAGPFHVASPELHPLYHYKTYV GGILLLSKQHYRLCNGMSNRFWGWG REDDEFYRRIKGAGLQLFRPSGITT GYKTFRHLHDPAWRKRDQKRIAAQK QEQFKVDREGGLNTVKYHVASRTAL SVGGAPCTVLNIMLDCDKTATPWCT FS |
| Notes : |
Best use within three months from the date of receipt of this protein. |
| Storage : |
Store at -80 centigrade. Aliquot to avoid repeated freezing and thawing. |
| Storage Buffer : |
50 mM Tris-HCI, 10 mM reduced Glutathione, pH=8.0 in the elution buffer. |
