bach1

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bach1

Official Full Name BTB and CNC homology 1, basic leucine zipper transcription factor 1
Background This gene encodes a transcription factor that belongs to the capncollar type of basic region leucine zipper factor family (CNC-bZip). The encoded protein contains broad complex, tramtrack, bric-a-brac/poxvirus and zinc finger (BTB/POZ) domains, which is atypical of CNC-bZip family members. These BTB/POZ domains facilitate protein-protein interactions and formation of homo- and/or hetero-oligomers. When this encoded protein forms a heterodimer with MafK, it functions as a repressor of Maf recognition element (MARE) and transcription is repressed. Multiple alternatively spliced transcript variants have been identified for this gene.
Synonyms BACH1; BTB and CNC homology 1, basic leucine zipper transcription factor 1; transcription regulator protein BACH1; BACH 1; HA2303; BTB and CNC homolog 1; basic region leucine zipper transcriptional regulator BACH1; BACH-1
    • Species :
    • Human
    • Mouse
    • Rhesus Macaque
    • Source :
    • HEK293
    • HEK293T
    • Mammalian Cell
    • Wheat Germ
    • Tag :
    • GST
    • His
    • MYC/DDK
    • Myc
    • DDK
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human BACH1-001H Recombinant Human BACH1 Protein, MYC/DDK-tagged HEK293T Myc/DDK
    Human BACH1-044H Recombinant Human BACH1 protein, GST-tagged Wheat Germ GST
    Human BACH1-22H Recombinant Human BACH1 Protein, MYC/DDK-tagged HEK293T Myc/DDK
    Human BACH1-27427TH Recombinant Human BACH1 Wheat Germ N/A
    Human BACH1-3374H Recombinant Human BACH1 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
    Human BACH1-4068H Recombinant Human BACH1 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
    Human BACH1-8531HCL Recombinant Human BACH1 293 Cell Lysate HEK293 N/A
    Human BACH1-8532HCL Recombinant Human BACH1 293 Cell Lysate HEK293 N/A
    Mouse BACH1-2267M Recombinant Mouse BACH1 Protein Mammalian Cell His
    Mouse Bach1-687M Recombinant Mouse Bach1 Protein, MYC/DDK-tagged HEK293T MYC/DDK
    Rhesus Macaque BACH1-504R Recombinant Rhesus monkey BACH1 Protein, His-tagged Mammalian Cell His

    bach1 involved in several pathways and played different roles in them. We selected most pathways bach1 participated on our site, such as Integrated Breast Cancer Pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with bach1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Integrated Breast Cancer Pathway PLK3; JAKMIP1; DAG1; SELK; BACH1; EDAR; C21orf7; NOXA1; USP38; CYP19A1

    bach1 has several biochemical functions, for example, RNA polymerase II distal enhancer sequence-specific DNA binding, heme binding, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by bach1 itself. We selected most functions bach1 had, and list some proteins which have the same functions with bach1. You can find most of the proteins on our site.

    Function Related Protein
    RNA polymerase II distal enhancer sequence-specific DNA binding CDX2; NR5A2; NR1H4; MIXL1; H2AFZ; RELA; MED12; GATA2; TFAP2C; SFPQ
    heme binding CYP51A1; CYP2X9; IRGM1; CYP4X1; CYP2C70; CYP2K16; IDO1; CYP8B3; CYP4F3; HBZ
    protein binding GRIK5; TMEM8B; SERPINA3; ASGR2; LAMTOR1; CSF3R; TMEM100; DGKZ; NME3; RABEP1
    transcription factor activity, sequence-specific DNA binding RFX8; POUV; GCM1; CITED2; NFE2L1B; ZFP110; AFF4; ZNF193; ATF7; ZNF202
    transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific binding SIX6; ARID3B; SUB1; MEOX2; CUX1; NFE2L1; BACH1; NFE2L2; RELA; NFATC1
    transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding NR2C1; PROX1A; ZFP90; NFIL3-6; CREBBP; ZFPM2A; NEUROG3; SPI1; NKX6-2; TGIF1
    transcriptional repressor activity, RNA polymerase II distal enhancer sequence-specific binding PROP1; GZF1; BACH1; PAX4; MSC; ZBTB16; ARX; BACH2
    contributes_to ubiquitin-protein transferase activity KLHL24B; BACH2; KLHL20; BCOR; BACH1A; KLHL2; TCEB3C; IPP; FBXL15; KLHL10

    bach1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with bach1 here. Most of them are supplied by our site. Hope this information will be useful for your research of bach1.

    MAFG; MAF; FOS; ATF2; CREB1; ATF7; ATF1; DDIT3; BATF; meq_gahvm; MAFB; Bach1; ANAPC5; h0y2u5_human; TMEM208

    Itoh-Nakadai, A; Hikota, R; et al. The transcription repressors Bach2 and Bach1 promote B cell development by repressing the myeloid program. NATURE IMMUNOLOGY 15:1171-1180(2014).
    Igarashi, K; Watanabe-Matsui, M; et al. Wearing Red for Signaling: The Heme-Bach Axis in Heme Metabolism, Oxidative Stress Response and Iron Immunology. TOHOKU JOURNAL OF EXPERIMENTAL MEDICINE 232:229-253(2014).

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