|Official Full Name||B-cell CLL/lymphoma 11A (zinc finger protein)|
|Background||This gene encodes a C2H2 type zinc-finger protein by its similarity to the mouse Bcl11a/Evi9 protein. The corresponding mouse gene is a common site of retroviral integration in myeloid leukemia, and may function as a leukemia disease gene, in part, through its interaction with BCL6. During hematopoietic cell differentiation, this gene is down-regulated. It is possibly involved in lymphoma pathogenesis since translocations associated with B-cell malignancies also deregulates its expression. Multiple transcript variants encoding several different isoforms have been found for this gene.|
|Synonyms||BCL11A; B-cell CLL/lymphoma 11A (zinc finger protein); ecotropic viral integration site 9 , EVI9; B-cell lymphoma/leukemia 11A; BCL11A L; BCL11A S; BCL11A XL; CTIP1; HBFQTL5; ZNF856; EVI-9; BCL-11A; zinc finger protein 856; C2H2-type zinc finger protein|
|Species||Cat.#||Product name||Source (Host)||Tag||Protein Length||Price|
BCL11A involved in several pathways and played different roles in them. We selected most pathways BCL11A participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with BCL11A were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
|Pathway Name||Pathway Related Protein|
BCL11A has several biochemical functions, for example, RNA polymerase II core promoter proximal region sequence-specific DNA binding, metal ion binding, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by BCL11A itself. We selected most functions BCL11A had, and list some proteins which have the same functions with BCL11A. You can find most of the proteins on our site.
|RNA polymerase II core promoter proximal region sequence-specific DNA binding||CREB1; TCF3B; CREB3L2; MYOG; JUNBA; CC2D1A; EBF2; ZNF92; CEBPG; PER1|
|metal ion binding||ANKIB1A; GUCA1D; ING5B; RUFY4; ELAC2; TRIM30A; ZNF334; COL27A1B; OSGEP; ZBBX|
|protein binding||ZNF496; KLF4; MLF1; CLPB; NGFRB; CASP14; TLE1; STX4A; NCKIPSD; PITX2|
|protein heterodimerization activity||SYCP2; H3F3C; DLG4B; BARD1; GCLM; HIST1H4A; MAPK6; NR4A2; H3F3A; HIST1H47|
|protein homodimerization activity||SLC6A4; NLGN4X; TRPM8; IRAK3; CRYBB2; BAX; HPS4; LRRC41; CBX1; USH2A|
|transcription corepressor activity||RUNX1T1; SKI; TFCP2L1; FOXP3; ZHX2; POU1F1; LMCD1; ZFPM1; CREG1; SUFU|
|transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding||HHEX; TBX3; BCL11AB; PRDM5; NKX3-2; GFI1; GATA1; ETS2; SNAI1; BACH1|
BCL11A has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with BCL11A here. Most of them are supplied by our site. Hope this information will be useful for your research of BCL11A.
CDK4; CDK6; hbg2_human_dna; ACTC1; q8czv1_yerpe; YME1L1; CDCA3; AIM2; BCL6; HDAC1; HDAC2