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BEST1

  • Official Full Name

    bestrophin 1

  • Overview

    This gene encodes a member of the bestrophin gene family. This small gene family is characterized by proteins with a highly conserved N-terminus with four to six transmembrane domains. Bestrophins may form chloride ion channels or may regulate voltage-gated L-type calcium-ion channels. Bestrophins are generally believed to form calcium-activated chloride-ion channels in epithelial cells but they have also been shown to be highly permeable to bicarbonate ion transport in retinal tissue. Mutations in this gene are responsible for juvenile-onset vitelliform macular dystrophy (VMD2), also known as Best macular dystrophy, in addition to adult-onset vitelliform macular dystrophy (AVMD) and other retinopathies. Alternative splicing results in multiple variants encoding distinct isoforms.
  • Synonyms

    BEST1; bestrophin 1; vitelliform macular dystrophy 2 , VMD2; bestrophin-1; BEST; Best disease; BMD; BEST 1; Best macular dystrophy; BEST1_HUMAN; Bestrophin1; mBest1; TU15B; Vitelliform macular dystrophy 2; Vitelliform macular dystrophy; Vitelliform macular dystrophy protein 2; VMD 2; VMD2; OTTHUMP00000235994; OTTHUMP00000235998; OTTHUMP00000235999; OTTHUMP00000236000; ARB; RP50;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Cynomolgus Monkey
  • Homo sapiens (Human)
  • Human
  • Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey)
  • Mouse
  • Mus musculus (Mouse)
  • Sus scrofa (Pig)
  • E.coli
  • E.coli expression system
  • HEK293
  • HEK293T
  • In Vitro Cell Free System
  • Mammalian Cell
  • Mammalian cells
  • Wheat Germ
  • Flag
  • GST
  • His
  • His (Fc)
  • Avi
  • Myc
  • DDK
  • Myc|DDK
  • N/A
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human BEST1-196H Recombinant Human BEST1 Protein, GST-tagged Wheat Germ GST
Human BEST1-503H Recombinant Human bestrophin 1, His-tagged E.coli His
Human BEST1-10208H Recombinant Human BEST1, GST-tagged E.coli GST C-term-180a.a.
Human BEST1-5104H Recombinant Human BEST1, His-tagged E.coli His
Human BEST1-1910HCL Recombinant Human BEST1 cell lysate N/A
Human BEST1-2597H Recombinant Human BEST1 Protein, MYC/DDK-tagged HEK293 Myc/DDK
Human BEST1-1573HF Recombinant Full Length Human BEST1 Protein, GST-tagged In Vitro Cell Free System GST 604 amino acids
Human BEST1-1857HFL Recombinant Full Length Human BEST1 Protein, C-Flag-tagged Mammalian cells Flag
Human BEST1-447H Recombinant Human BEST1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Human BEST1-447H-B Recombinant Human BEST1 Protein Pre-coupled Magnetic Beads HEK293
Mouse BEST1-2376M Recombinant Mouse BEST1 Protein Mammalian Cell His
Mouse BEST1-1012M Recombinant Mouse BEST1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse BEST1-1012M-B Recombinant Mouse BEST1 Protein Pre-coupled Magnetic Beads HEK293
Mouse Best1-1859M Recombinant Mouse Best1 Protein, Myc/DDK-tagged HEK293T Myc/DDK
Cynomolgus Monkey BEST1-342C Recombinant Cynomolgus BEST1 Protein, His-tagged Mammalian Cell His
Cynomolgus Monkey BEST1-90C-B Recombinant Cynomolgus Monkey BEST1 Protein Pre-coupled Magnetic Beads HEK293
Cynomolgus Monkey BEST1-90C Recombinant Cynomolgus Monkey BEST1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Homo sapiens (Human) RFL2382HF Recombinant Full Length Human Bestrophin-1(Best1) Protein, His-Tagged E.coli expression system His Full Length (1-585)
Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey) RFL30674MF Recombinant Full Length Macaca Fascicularis Bestrophin-1(Best1) Protein, His-Tagged E.coli expression system His Full Length (1-585)
Mus musculus (Mouse) RFL18265MF Recombinant Full Length Mouse Bestrophin-1(Best1) Protein, His-Tagged E.coli expression system His Full Length (1-551)
Sus scrofa (Pig) RFL31245SF Recombinant Full Length Pig Bestrophin-1(Best1) Protein, His-Tagged E.coli expression system His Full Length (1-428)
  • Involved Pathway
  • Protein Function
  • Interacting Protein

BEST1 involved in several pathways and played different roles in them. We selected most pathways BEST1 participated on our site, such as Ion channel transport, Stimuli-sensing channels, Transmembrane transport of small molecules, which may be useful for your reference. Also, other proteins which involved in the same pathway with BEST1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Ion channel transportCLCN4;CUTC;ASIC1A;TRPM4C;TPCN1;ATP13A1;WWP1;FXYD3;ANO7
Stimuli-sensing channelsUNC79;SCNN1D;ANO10A;ANO9;ASPH;CLCNK;WNK1;TRPC4AP;CLCN1
Transmembrane transport of small moleculesSLC7A3A;SLC26A6L;SLC22A7;BEST1;SLC4A1A;WNK2;TRPC4AP;BSND;SRI

BEST1 has several biochemical functions, for example, chloride channel activity, contributes_to chloride channel activity. Some of the functions are cooperated with other proteins, some of the functions could acted by BEST1 itself. We selected most functions BEST1 had, and list some proteins which have the same functions with BEST1. You can find most of the proteins on our site.

Function Related Protein
chloride channel activityGABRD;SLC26A11;GRAP2;GABRA5;FXYD1;TTYH3B;SLC26A4;GABRP;GABRB2
contributes_to chloride channel activityGABRB2;GABRB1;BEST4;BEST3;GABRR3A;GABRR2;BEST2;GABRR2A;GABRQ

BEST1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with BEST1 here. Most of them are supplied by our site. Hope this information will be useful for your research of BEST1.

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