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BLM

  • Official Full Name

    Bloom syndrome, RecQ helicase-like

  • Overview

    The Bloom syndrome gene product is related to the RecQ subset of DExH box-containing DNA helicases and has both DNA-stimulated ATPase and ATP-dependent DNA helicase activities. Mutations causing Bloom syndrome delete or alter helicase motifs and may disable the 3-5 helicase activity.The normal protein may act to suppress inappropriate recombination.
  • Synonyms

    BLM; Bloom syndrome, RecQ helicase-like; Bloom syndrome; Bloom syndrome protein; BS; RECQ2; RECQL3; recQ protein-like 3; DNA helicase, RecQ-like type 2; RECQL2; MGC126616; MGC131618; MGC131620;

  • Recombinant Proteins
  • Protein Pre-coupled Magnetic Beads
  • Chicken
  • Human
  • Mouse
  • E.coli
  • HEK293
  • Mammalian Cell
  • Wheat Germ
  • GST
  • His
  • His (Fc)
  • Avi
  • His|Myc
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human BLM-241H Recombinant Human BLM Protein, GST-tagged Wheat Germ GST
Human BLM-34H Recombinant Human BLM Protein E.coli
Mouse BLM-2415M Recombinant Mouse BLM Protein Mammalian Cell His
Mouse BLM-2206M Recombinant Mouse BLM Protein (684-859 aa), His-Myc-tagged E.coli His/Myc 684-859 aa
Mouse BLM-1040M-B Recombinant Mouse BLM Protein Pre-coupled Magnetic Beads HEK293
Mouse BLM-1040M Recombinant Mouse BLM Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Chicken BLM-1738C Recombinant Chicken BLM Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • BLM Related Articles

BLM involved in several pathways and played different roles in them. We selected most pathways BLM participated on our site, such as Homologous recombination, Fanconi anemia pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with BLM were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Homologous recombinationBLM;RAD54L;SSBP1;SYCP3;RPA2;RAD51L3;RAD51L1;POLD1;POLD4
Fanconi anemia pathwayRAD51C;RPA1;CDK5R2;MLH1;FANCI;POLI;DCLRE1A;ERCC1;FAN1

BLM has several biochemical functions, for example, ATP binding, ATP-dependent 3-5 DNA helicase activity, ATP-dependent DNA helicase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by BLM itself. We selected most functions BLM had, and list some proteins which have the same functions with BLM. You can find most of the proteins on our site.

Function Related Protein
ATP bindingMAPK3;ASS1;NUAK2;YARS2;EHD4;ATP6V1BA;PTK6;GSK3AB;RPS6KA3
ATP-dependent 3-5 DNA helicase activityASCC3;RECQL4;WRN;BLM
ATP-dependent DNA helicase activityFBXO18;XRCC5;G3BP1;DDX11;CHD1;BRIP1;CHD4;CHST13;GTF2H4
ATP-dependent helicase activityRECQL5;CHD4A;DHX36;ERCC6L2;TTF2;BLM;CHD6;SNRNP200;RTEL1
ATPase activityTOR1B;ATF7IP;HSPA1A;ABCE1;HSP90AA1;ABCC1;ABCG3;DNAH6;PICK1
DNA bindingEGR3;KLF14;SIX2B;HLFA;ENG2B;ADAR;HOXB8B;FOXO6;IRX2A
G-quadruplex DNA bindingWRN;LONP1;DHX36;BLM
annealing helicase activityRECQL4;RAD54L;ANXA1;ZRANB3;BLM;SMARCAL1;RECQL
bubble DNA bindingBLM;HMGB1;ERCC5;NEIL3;WRN;RECQL4
catalytic activityECI2;ISOC2;HOGA1;AGLA;LYZ2;TM9SF1;EML5;ALDOAA;CKBB
four-way junction helicase activityBLM;WRN
helicase activityFANCM;SHPRH;EIF4A1;HELQ;UPF1;DHX32A;CHD9;DDX58;PIF1
hydrolase activityHDAC9B;ABHD8;PPM1AA;ST14A;PRSS28;ANG4;C1rb;KLK1B11;ATP1A3A
hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydridesRTEL1;CHD4A;BLM
nucleic acid bindingSNRNP27;Akap17b;HNRNPA0L;GPATCH1;EIF2S1A;FAM90A1;EXOG;ZBTB46;ZFP536
nucleotide bindingAPOA1BP;GSPT1L;EPHA4A;HNRNPH1L;PFKMB;RHOU;ATP1A3A;SETX;CAMK2G1
p53 bindingTRP63;STK11;ZFP346;MSX1;KDM1A;TP53;TRP53;TRIAP1;BRD4
protein bindingRPA3;C1QTNF9B-AS1;MVP;NUP107;FOXP1;RNF216;MBD4;GGA3;TXN2
single-stranded DNA bindingHNRNPK;CDAN1;RAD51AP1;MCM6;BRCA2;RBMS1;TTC6;TDP1;LRPPRC

BLM has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with BLM here. Most of them are supplied by our site. Hope this information will be useful for your research of BLM.

Aono, Y; Kishi, M; et al. Role of Platelet-Derived Growth Factor/Platelet-Derived Growth Factor Receptor Axis in the Trafficking of Circulating Fibrocytes in Pulmonary Fibrosis. AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY 51:793-801(2014).
Li, J; Wang, G; et al. Transforming growth factor beta regulates beta-catenin expression in lung fibroblast through NF-kappa B dependent pathway. INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE 34:1219-1224(2014).
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