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Official Full Name Bloom syndrome, RecQ helicase-like
Background The Bloom syndrome gene product is related to the RecQ subset of DExH box-containing DNA helicases and has both DNA-stimulated ATPase and ATP-dependent DNA helicase activities. Mutations causing Bloom syndrome delete or alter helicase motifs and may disable the 3-5 helicase activity.The normal protein may act to suppress inappropriate recombination.
Synonyms BLM; Bloom syndrome, RecQ helicase-like; Bloom syndrome; Bloom syndrome protein; BS; RECQ2; RECQL3; recQ protein-like 3; DNA helicase, RecQ-like type 2; RECQL2; MGC126616; MGC131618; MGC131620
    • Species :
    • Chicken
    • Human
    • Mouse
    • Source :
    • E.coli
    • Mammalian Cell
    • Wheat Germ
    • Tag :
    • GST
    • His
    • Myc
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human BLM-241H Recombinant Human BLM Protein, GST-tagged Wheat Germ GST
    Mouse BLM-2206M Recombinant Mouse BLM Protein (684-859 aa), His-Myc-tagged E.coli His/Myc
    Mouse BLM-2415M Recombinant Mouse BLM Protein Mammalian Cell His
    Chicken BLM-1738C Recombinant Chicken BLM Mammalian Cell His

    blm involved in several pathways and played different roles in them. We selected most pathways blm participated on our site, such as Homologous recombination, Fanconi anemia pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with blm were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Homologous recombination BLM; RPA2; RPA1; MRE11A; BRCA2; RAD51D; MUS81; FUZ; XRCC2; POLD1
    Fanconi anemia pathway RAD51; TOP3B; CDK5R2; BRCA1; RPA2; PMS2; USP1; DCLRE1A; ATRIP; USP36

    blm has several biochemical functions, for example, ATP binding, ATP-dependent 3-5 DNA helicase activity, ATP-dependent DNA helicase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by blm itself. We selected most functions blm had, and list some proteins which have the same functions with blm. You can find most of the proteins on our site.

    Function Related Protein
    ATP-dependent 3-5 DNA helicase activity BLM; RECQL4; ASCC3; WRN
    ATP-dependent DNA helicase activity DHX9; CHD2; CHD4; XRCC6; ERCC2; RUVBL2; FBXO18; DDX11; DDX3X; RECQL
    ATP-dependent helicase activity BLM; ERCC6L2; TTF2; RTEL1; DHX37; CHD4A; SNRNP200; RECQL5; DHX36; CHD6
    ATPase activity ATAD2B; PSMD6; KIF22; PMS2; DNAHC8; EIF4A1B; KIF20A; ABCF1; SMARCA5; KIF21A
    DNA binding TRIM33; TEAD2; RFX1A; FOXC1A; PCBP4; ZNF48; ZFP423; ZNF212; POLR2EB; HER8A
    G-quadruplex DNA binding DHX36; WRN; BLM; LONP1
    annealing helicase activity RECQL; RAD54L; ANXA1; SMARCAL1; ZRANB3; RECQL4; BLM
    bubble DNA binding RECQL4; ERCC5; HMGB1; NEIL3; BLM; WRN
    catalytic activity ETNPPL; ALDOCB; EML5; HSD17B1; RDH7; SULF2B; FH1; ACSL4B; YDJC; PPTC7A
    four-way junction helicase activity BLM; WRN
    helicase activity DHX57; ZRANB3; MOV10B.1; RTEL1; IFIH1; TDRD12; SHPRH; EIF4A1B; DNA2; ERCC6L
    hydrolase activity TMPRSS13A; SPACA5; WRNIP1; DDX3; IRGC; PPM1DA; ATP1A1A.1; MCPT2; CES1C; PTPN23A
    hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides BLM; CHD4A; RTEL1
    nucleic acid binding BLF; EIF2C3; RNASE13; ZNFL1; ZIC5; REXO2; ZFP879; PRDM7; RNASE9; FAM90A1
    nucleotide binding CLPXA; ZRANB3; SRPK1B; SF3B14; GSK3AA; RABL6; SFPQ; TUBB5; PABPC1B; PRKG1A
    p53 binding MDM2; CDK5; TRP53; PSME3; EHMT1; TP63; EHMT2; TP53BP1; BANP; TRIAP1
    protein binding DICER1; ITGB1BP1; TUBA3E; NPLOC4; IQCE; RPLP1; C16orf48; YTHDF3; TMEM185A; STRAP
    single-stranded DNA binding HNRPDL; TDP2; NUP35; MCM4; RBMS1; CDAN1; SUB1; RAD51; OBFC2B; TSNAX

    blm has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with blm here. Most of them are supplied by our site. Hope this information will be useful for your research of blm.

    Aono, Y; Kishi, M; et al. Role of Platelet-Derived Growth Factor/Platelet-Derived Growth Factor Receptor Axis in the Trafficking of Circulating Fibrocytes in Pulmonary Fibrosis. AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY 51:793-801(2014).
    Li, J; Wang, G; et al. Transforming growth factor beta regulates beta-catenin expression in lung fibroblast through NF-kappa B dependent pathway. INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE 34:1219-1224(2014).

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