brca1
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  • Official Full Name
  • breast cancer 1, early onset
  • Background
  • Breast Cancer Gene 1 (BRCA1) is phosphorylated at Ser1524, and occurs in response to ionizing and ultraviolet radiation.
  • Synonyms
  • BRCA1; breast cancer 1, early onset; breast cancer type 1 susceptibility protein; BRCA1/BRCA2 containing complex; subunit 1; BRCC1; PPP1R53; protein phosphatase 1; regulatory subunit 53; RNF53; RING finger protein 53; BRCA1/BRCA2-containing complex, subunit 1; protein phosphatase 1, regulatory subunit 53; breast and ovarian cancer susceptibility protein 1; breast and ovarian cancer sususceptibility protein 1; IRIS; PSCP; BRCAI; PNCA4; BROVCA1
Cat.#:BRCA1-1018HTag:N/A
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human Breast Cancer 1, Early Onset
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Cat.#:BRCA1-10279HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human BRCA1, GST-tagged
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Cat.#:BRCA1-325HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human BRCA1 Protein, GST-tagged
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Cat.#:BRCA1-42HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human BRCA1 protein, GST-tagged
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Cat.#:BRCA1-6881HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human BRCA1 protein, His-tagged
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Cat.#:BRCA1-8497HTag:His
Source (Host):Sf 21 Insect cellsSpecies:Human
Product nameRecombinant Human BRCA1, His-tagged
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Cat.#:BRCA1-2479MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse BRCA1 Protein
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Cat.#:Brca1-6882MTag:His|T7
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Brca1 protein, His & T7-tagged
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Cat.#:BRCA1-1010RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat BRCA1 Protein
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Cat.#:Brca1-6883RTag:His|GST
Source (Host):E. coliSpecies:Rat
Product nameRecombinant Rat Brca1 protein, His & GST-tagged
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Cat.#:BRCA1-349CTag:His
Source (Host):Mammalian CellsSpecies:Cynomolgus Monkey
Product nameRecombinant Cynomolgus BRCA1 Protein, His-tagged
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Cat.#:BRCA1-562RTag:His
Source (Host):Mammalian CellsSpecies:Rhesus Macaque
Product nameRecombinant Rhesus monkey BRCA1 Protein, His-tagged
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Cat.#:BRCA1-5743CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken BRCA1
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Involved Pathway

BRCA1 involved in several pathways and played different roles in them. We selected most pathways BRCA1 participated on our site, such as Fanconi anemia pathway, Ubiquitin mediated proteolysis, PIK-Akt signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with BRCA1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Fanconi anemia pathway
CDK5R2; RPA4; FANCI; FANCC; RAD51C; RMI2; USP1; BRCA1; FUZ; ERCC4
Ubiquitin mediated proteolysis
CUL2; UBE2M; CUL5; UBE2KA; UBE2E3; UBE2D2L; CDC26; ANAPC7; BIRC2; PPIL2
PIK-Akt signaling pathway
NRAS; GYS1; FGF12; HRAS; PDGFC; IFNA8; IL7R; INS1; IFNA17; NGF
MicroRNAs in cancer
PIK3CA; MARCKS; RAF1; EZR; TTC6; WNT3A; CYP24A1; NFKB1; RPS6KA5; TP53

Protein Function

BRCA1 has several biochemical functions, for example, DNA binding, RNA binding, androgen receptor binding. Some of the functions are cooperated with other proteins, some of the functions could acted by BRCA1 itself. We selected most functions BRCA1 had, and list some proteins which have the same functions with BRCA1. You can find most of the proteins on our site.
Function
Related Protein
Function DNA binding
Related Protein MIER2; NKX2-1; GTF2F1; VEPH1; POU3F3; MIER3; ZBED1; TFB1M; PCGF6; ZNF468
Function RNA binding
Related Protein RPL6; BXDC2; UNC50; TRIM32; HUG; KHDC1C; METTL14; ZFML; RPL22; RPS5
Function androgen receptor binding
Related Protein RB1; PRKCBB; DDX5; BRCA1; Ar; PIAS1; CTNNB1; FOXH1; KDM4C; NCOA1
Function damaged DNA binding
Related Protein CRY2; RPS3; NEIL1; TP63; RBBP8; ERCC4; UNG; RPA2; NEIL2; TDG
Function enzyme binding
Related Protein ITGB3; CCND1; PRKCA; HSPA1A; CSF3; BIRC7; PTPN1; CYP3A4; PLSCR4; GOLPH3
Function ligase activity
Related Protein HECTD2; CBLL1; TRIM38; UBE2G1B; RNF146; ARIH2; PDZRN3; UBOX5; HERC6; BIRC2
Function protein binding
Related Protein SLMAP; KIF1C; MAGEH1; KRT18; ZNF502; SCRN1; MINOS1; PDIK1L; ZFAND2B; MTCH1
Function transcription coactivator activity
Related Protein NFATC4; USP22; MED16; NACA; FHL2; UTF1; WWTR1; GRIP1; JUNB; GTF2F1
Function transcription regulatory region DNA binding
Related Protein H2AFY; ERBB4; KCNA3; HDAC1; KLF17; PROX1; EGR2; ZNF649; ZBTB14; ZFP513
Function tubulin binding
Related Protein STMN4; BIRC5; TPR; BRCA1; AGBL1; EML2; STMN1B; EML1; AGBL5; STMN3
Function ubiquitin protein ligase binding
Related Protein ACTG1; PACRG; HSPA9; ZFP746; AXIN1; CUL9; MAP1LC3C; CCT2; LC3; SMC6
Function ubiquitin-protein transferase activity
Related Protein RNF20; BARD1; WWP2; RNF141; RNF10; UBE2M; CDC23; UBA1; CBL; SMURF2
Function zinc ion binding
Related Protein PGLYRP3; PHF20B; IRGF4; CAHZ; MSL2B; TRIM16; ADAMTSL3; SP140L; KAT7; BAZ1A

Interacting Protein

BRCA1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with BRCA1 here. Most of them are supplied by our site. Hope this information will be useful for your research of BRCA1.
BRIP1; BARD1

BRCA1 Related Articles

Seksenyan, A; Kadavallore, A; et al. TOX3 is expressed in mammary ER+ epithelial cells and regulates ER target genes in luminal breast cancer. BMC CANCER 15:-(2015).
Kast, K; Rhiem, K; et al. Familial Breast Cancer - Targeted Therapy in Secondary and Tertiary Prevention. BREAST CARE 10:27-31(2015).