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Official Full Name breast cancer 1, early onset
Background Breast Cancer Gene 1 (BRCA1) is phosphorylated at Ser1524, and occurs in response to ionizing and ultraviolet radiation.
Synonyms BRCA1; breast cancer 1, early onset; breast cancer type 1 susceptibility protein; BRCA1/BRCA2 containing complex; subunit 1; BRCC1; PPP1R53; protein phosphatase 1; regulatory subunit 53; RNF53; RING finger protein 53; BRCA1/BRCA2-containing complex, subunit 1; protein phosphatase 1, regulatory subunit 53; breast and ovarian cancer susceptibility protein 1; breast and ovarian cancer sususceptibility protein 1; IRIS; PSCP; BRCAI; PNCA4; BROVCA1
    • Species :
    • Chicken
    • Cynomolgus Monkey
    • Human
    • Mouse
    • Rat
    • Rhesus Macaque
    • Source :
    • E.coli
    • Mammalian Cell
    • Sf21 Insect Cell
    • Sf9 Insect Cell
    • Wheat Germ
    • Tag :
    • GST
    • His
    • T7
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human BRCA1-1018H Recombinant Human Breast Cancer 1, Early Onset Sf9 Insect Cell N/A
    Human BRCA1-10279H Recombinant Human BRCA1, GST-tagged E.coli GST
    Human BRCA1-325H Recombinant Human BRCA1 Protein, GST-tagged Wheat Germ GST
    Human BRCA1-42H Recombinant Human BRCA1 protein, GST-tagged E.coli GST
    Human BRCA1-6881H Recombinant Human BRCA1 protein, His-tagged E.coli His
    Human BRCA1-8497H Recombinant Human BRCA1, His-tagged Sf21 Insect Cell His
    Mouse BRCA1-2479M Recombinant Mouse BRCA1 Protein Mammalian Cell His
    Mouse Brca1-6882M Recombinant Mouse Brca1 protein, His & T7-tagged E.coli His/T7
    Rat BRCA1-1010R Recombinant Rat BRCA1 Protein Mammalian Cell His
    Rat Brca1-6883R Recombinant Rat Brca1 protein, His & GST-tagged E.coli His/GST
    Cynomolgus Monkey BRCA1-349C Recombinant Cynomolgus BRCA1 Protein, His-tagged Mammalian Cell His
    Rhesus Macaque BRCA1-562R Recombinant Rhesus monkey BRCA1 Protein, His-tagged Mammalian Cell His
    Chicken BRCA1-5743C Recombinant Chicken BRCA1 Mammalian Cell His

    brca1 involved in several pathways and played different roles in them. We selected most pathways brca1 participated on our site, such as Fanconi anemia pathway, Ubiquitin mediated proteolysis, PIK-Akt signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with brca1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Fanconi anemia pathway TELO2; SLX4; FANCB; FANCA; POLN; TOP3B; FANCL; FANCG; MUS81; REV1
    Ubiquitin mediated proteolysis UBE2W; FANCL; ANAPC11; UBE2E2; SIAH1A; KEAP1B; ANAPC2; NEDD4L; SAE1; UBE2NA
    PIK-Akt signaling pathway IL6R; SYK; LAMB3; IFNA12; EPO; THBS2; PIK3CD; HSP90B1; ITGA7; PKN3
    MicroRNAs in cancer NOTCH3; MTOR; PDGFA; ROCK1; CDC25B; ZFPM2; FZD3; DNMT3A; PLCG1; SPRY2

    brca1 has several biochemical functions, for example, DNA binding, RNA binding, androgen receptor binding. Some of the functions are cooperated with other proteins, some of the functions could acted by brca1 itself. We selected most functions brca1 had, and list some proteins which have the same functions with brca1. You can find most of the proteins on our site.

    Function Related Protein
    androgen receptor binding FOXH1; DAXX; NSD1; CALR; PRKCBB; BRCA1; RAN; Ar; EP300; WIPI1
    damaged DNA binding HMGB1; OGG1; APTX; APEX1; TDG; CREBBP; ERCC1; RAD23B; POLI; FANCG
    enzyme binding HIST1H2AN; PLSCR1; CBX1; Slc4a2; PARK7; LAMP1; CALU; TOP2A; CSF3; HSPA1A
    ligase activity TRAIP; BRAP; PRPF19; NSMCE2; LNX1; NSMCE1; MKRN1; MARCH5L; BTR22; MID2
    protein binding LRRC4C; RRAGA; SLC30A1; CDK16; C3; TACR1; ZW10; NSG1; FAM3C; EED
    transcription coactivator activity SUB1B; MED26; ASXL1; ZEB1; NPM1; SUB1A; MED21; NFATC4; CITED2; TAF12
    transcription regulatory region DNA binding KLF11; BASP1; TCF7; GABPB1; NR1D1; SREBF1; NR1H3; ATF4; FOXC2; KLF17
    tubulin binding GPAA1; NCALD; STMN3; VBP1; STMN1; STMN4L; LRRK2; STMN1A; RPS3; STMN4
    ubiquitin protein ligase binding RAD18; TCEB2; C10orf46; UBE2G1; YWHAZ; MFN2; CDC34; ARRB2; USP25; NDUFS2
    ubiquitin-protein transferase activity MUL1; RNF152; RNF187; HECTD3; FBXO30B; SMURF2; UBE2G1; RNF217; UBE2D4; FBXO21
    zinc ion binding FTR54; MBD1B; NR1H5; MICAL2B; TRIM35-19; BTY; PDLIM7; RORB; ADH1A; ZDHHC24

    brca1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with brca1 here. Most of them are supplied by our site. Hope this information will be useful for your research of brca1.

    BRIP1; BARD1

    Seksenyan, A; Kadavallore, A; et al. TOX3 is expressed in mammary ER+ epithelial cells and regulates ER target genes in luminal breast cancer. BMC CANCER 15:-(2015).
    Kast, K; Rhiem, K; et al. Familial Breast Cancer - Targeted Therapy in Secondary and Tertiary Prevention. BREAST CARE 10:27-31(2015).

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