CA12

  • Official Full Name

    carbonic anhydrase XII

  • Overview

    Carbonic anhydrases (CA) are a family of ancient zinc metalloenzymes found in almost all living organisms. All CA can be divided into 3 distinct classes (alpha, beta, and gamma) that evolved independently and have no significant homology in sequence and o
  • Synonyms

    CA12; carbonic anhydrase XII; carbonic anhydrase 12; HsT18816; CA-XII; carbonic dehydratase; carbonate dehydratase XII; tumor antigen HOM-RCC-3.1.3; CAXII; FLJ20151; CAR12; carbonic anyhydrase 12; CA XII; AI314958; 2310047E01Rik;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Antibody
  • Protein Pre-coupled Magnetic Beads
  • Human
  • Mouse
  • Rat
  • Rhesus Macaque
  • E.coli
  • HEK293
  • HEK293T
  • Human Cell
  • In Vitro Cell Free System
  • Insect Cell
  • Mammalian Cell
  • Mammalian cells
  • Mouse
  • Wheat Germ
  • Yeast
  • C
  • His
  • Flag
  • GST
  • Avi
  • His (Fc)
  • SUMO
  • Myc
  • DDK
  • Myc|DDK
  • N/A
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human CA12-971H Active Recombinant Human CA12 Protein, His-tagged Mammalian cells His Ala25-Gln291
Human CA12-26248TH Recombinant Human CA12 Wheat Germ N/A 100 amino acids
Human CA12-7846H Recombinant Human CA12 protein, His-tagged E.coli His Ala25~Leu302 (Accession # O43570)
Human CA12-10615H Recombinant Human CA12, GST-tagged E.coli GST 27-293a.a.
Human CA12-261H Recombinant Human CA12 protein(Met1-Gln291), His-tagged HEK293 C-His Met1-Gln291
Human CA12-104H Recombinant Human CA12, His-tagged Insect Cell His
Human CA12-805H Recombinant Human CA12 Protein Insect Cell N/A
Human CA12-0233H Recombinant Human CA12 Protein, GST-Tagged Wheat Germ GST
Human CA12-3061HCL Recombinant Human CA12 cell lysate Human Cell N/A
Human CA12-2032H Recombinant Human CA12 Protein, MYC/DDK-tagged HEK293 Myc/DDK
Human CA12-262HB Recombinant Human CA12, His & Avi-tagged, Biotinylated HEK293 His & Avi Ala 25 - Gln 291
Human CAB11484MH Mouse Anti-Human Carbonic Anhydrase XII Monoclonal Antibody Mouse N/A
Human CA12-478H-B Recombinant Human CA12 Protein Pre-coupled Magnetic Beads HEK293
Human CA12-3407H Recombinant Human CA12 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human CA12-5357H Recombinant Human CA12 protein, His-tagged Yeast His 25-301aa
Human CA12-262H Recombinant Human CA12, His & Avi-tagged HEK293 His & Avi Ala 25 - Gln 291
Human CA12-2733HF Recombinant Full Length Human CA12 Protein, GST-tagged In Vitro Cell Free System GST 354 amino acids
Human CA12-2616H Recombinant Human CA12 protein, His-SUMO-tagged E.coli His-SUMO 25-301aa
Human CA12-2169HFL Recombinant Full Length Human CA12 Protein, C-Flag-tagged Mammalian cells Flag
Human CA12-478H Recombinant Human CA12 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse CAR12-2714M Recombinant Mouse CAR12 Protein Mammalian Cell His
Mouse Car12-7847M Recombinant Mouse Car12 protein, His-tagged E.coli His Ala161~Ile318 (Accession # Q8CI85)
Mouse CA12-260M Active Recombinant Mouse CA12 protein(Met1-Ser301), His-tagged HEK293 C-His Met1-Ser301
Mouse CA12-3067MCL Recombinant Mouse CA12 cell lysate Human Cell N/A
Mouse CA12-1154M Recombinant Mouse CA12 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse Car12-1958M Recombinant Mouse Car12 Protein, Myc/DDK-tagged HEK293T Myc/DDK
Mouse CA12-1154M-B Recombinant Mouse CA12 Protein Pre-coupled Magnetic Beads HEK293
Mouse CA12-5491M Recombinant Mouse CA12 Protein (Ala25-Ser301), C-His tagged Mammalian cells C-His Ala25-Ser301
Rat Car12-7848R Recombinant Rat Car12 protein, His-tagged E.coli His Leu154~Ser307 (Accession # A2IBE2)
Rhesus Macaque CA12-595R Recombinant Rhesus monkey CA12 Protein, His-tagged Mammalian Cell His
Rhesus Macaque CA12-423R-B Recombinant Rhesus Macaque CA12 Protein Pre-coupled Magnetic Beads HEK293
Rhesus Macaque CA12-423R Recombinant Rhesus Macaque CA12 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • Other Resource

CA12 involved in several pathways and played different roles in them. We selected most pathways CA12 participated on our site, such as Nitrogen metabolism, which may be useful for your reference. Also, other proteins which involved in the same pathway with CA12 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Nitrogen metabolismCAR7;Car2;GLULB;CA5;CA7;CAR13;CA12;CA5A;Car12

CA12 has several biochemical functions, for example, carbonate dehydratase activity, zinc ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by CA12 itself. We selected most functions CA12 had, and list some proteins which have the same functions with CA12. You can find most of the proteins on our site.

Function Related Protein
carbonate dehydratase activityCA6;CA4B;CAHZ;CAR7;CAR13;CAR3;CA5;Car14;CA12
zinc ion bindingKDM4C;RUFY1;MORC2B;CYLD;CHORDC1;NSMCE1;FBXO30A;ANAPC11;GLI2

CA12 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CA12 here. Most of them are supplied by our site. Hope this information will be useful for your research of CA12.

SGSM2; ATP5C1; CUX1; LGALS7B; MAPK6; RDH11; TOE1; MRPL9; KATNBL1; DAXX

Research Area

Related articles

Pogue-Geile, KL; Kim, C; et al. Predicting Degree of Benefit From Adjuvant Trastuzumab in NSABP Trial B-31. JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE 105:1782-1788(2013).
Wilbur, DS; Chyan, MK; et al. Reagents for Astatination of Biomolecules. 6. An Intact Antibody Conjugated with a Maleimido-closo-Decaborate(2-) Reagent via Sulfhydryl Groups Had Considerably Higher Kidney Concentrations than the Same Antibody Conjugated with an Isothiocyanato-closo-Decaborate(2-) Reagent via Lysine Amines. BIOCONJUGATE CHEMISTRY 23:409-420(2012).
  • Q&As
  • Reviews

Q&As (7)

Ask a question
Are there any known inhibitors specific to CA12, and how do they impact its enzymatic function? 07/13/2021

Known inhibitors can be identified through drug screening assays, and their impact on CA12 can be studied using kinetic studies and cell-based assays.

In which specific cellular compartments is CA12 predominantly localized, and how does this localization influence its role? 06/12/2020

Cellular localization can be identified using immunofluorescence, subcellular fractionation, or electron microscopy.

What role does CA12 play in tumorigenesis, especially in hypoxic tumor environments? 08/29/2019

CA12 has been implicated in tumor progression, particularly in hypoxic environments, by modulating pH and thus influencing tumor cell survival and metastasis. This can be assessed using cellular assays and tumor models.

What downstream signaling pathways are activated or inhibited by CA12? 07/28/2019

Downstream pathways can be identified using pathway analysis tools, phosphoproteomics, and specific signal transduction assays.

How does CA12 activity get modulated under varying pH conditions? 04/08/2018

The activity modulation under different pH conditions can be determined using enzymatic assays and pH shift experiments.

How does CA12 expression vary in response to different cellular stressors or stimuli? 03/08/2018

Expression changes in response to stressors can be analyzed using techniques like qPCR, Western blotting, or proteomics following cellular treatment with specific agents.

How do genetic variants of the CA12 gene influence its protein structure and function? 10/18/2017

Genetic variants and their impact can be determined using structural models and functional assays comparing wild-type and mutant proteins.

Customer Reviews (3)

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Reviews
12/20/2022

    Professional assistance, invaluable for complex protein experiments.

    05/09/2021

      Cost-effective quantitation, ideal for budget-conscious labs.

      11/21/2020

        Impressive expertise, accelerates our research progress.

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