CA12
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Official Full Name
carbonic anhydrase XII
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Overview
Carbonic anhydrases (CA) are a family of ancient zinc metalloenzymes found in almost all living organisms. All CA can be divided into 3 distinct classes (alpha, beta, and gamma) that evolved independently and have no significant homology in sequence and o -
Synonyms
CA12; carbonic anhydrase XII; carbonic anhydrase 12; HsT18816; CA-XII; carbonic dehydratase; carbonate dehydratase XII; tumor antigen HOM-RCC-3.1.3; CAXII; FLJ20151; CAR12; carbonic anyhydrase 12; CA XII; AI314958; 2310047E01Rik;
- Recombinant Proteins
- Cell & Tissue Lysates
- Antibody
- Protein Pre-coupled Magnetic Beads
- Ala25-Gly299
- Ala25-Ser301
- Human
- Mouse
- Rat
- Rhesus Macaque
- C-His
- E.coli
- HEK293
- HEK293T
- Human Cell
- In Vitro Cell Free System
- Insect Cell
- Mammalian Cell
- Mammalian cells
- Mouse
- Wheat Germ
- Yeast
- Flag
- GST
- His
- Avi
- Fc
- SUMO
- Myc
- DDK
- Non
- Involved Pathway
- Protein Function
- Interacting Protein
- Other Resource
CA12 involved in several pathways and played different roles in them. We selected most pathways CA12 participated on our site, such as Nitrogen metabolism, which may be useful for your reference. Also, other proteins which involved in the same pathway with CA12 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name | Pathway Related Protein |
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Nitrogen metabolism | CA1;Car8;CAR7;CA4;CAR15;GLUL;CPS1;CA5;GLUD2 |
CA12 has several biochemical functions, for example, carbonate dehydratase activity, zinc ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by CA12 itself. We selected most functions CA12 had, and list some proteins which have the same functions with CA12. You can find most of the proteins on our site.
Function | Related Protein |
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carbonate dehydratase activity | Car14;CA15A;CA6;Car4;CAR13;CAR6;CA7;CAR7;CAR5A |
zinc ion binding | MICAL2B;LMO7;PDLIM1;TRIM25;RNF44;WHSC1L1;ADAM17A;BFAR;MGRN1 |
CA12 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CA12 here. Most of them are supplied by our site. Hope this information will be useful for your research of CA12.
SGSM2; ATP5C1; CUX1; LGALS7B; MAPK6; RDH11; TOE1; MRPL9; KATNBL1; DAXX
Research Area
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Q&As (7)
Ask a questionKnown inhibitors can be identified through drug screening assays, and their impact on CA12 can be studied using kinetic studies and cell-based assays.
Cellular localization can be identified using immunofluorescence, subcellular fractionation, or electron microscopy.
CA12 has been implicated in tumor progression, particularly in hypoxic environments, by modulating pH and thus influencing tumor cell survival and metastasis. This can be assessed using cellular assays and tumor models.
Downstream pathways can be identified using pathway analysis tools, phosphoproteomics, and specific signal transduction assays.
The activity modulation under different pH conditions can be determined using enzymatic assays and pH shift experiments.
Expression changes in response to stressors can be analyzed using techniques like qPCR, Western blotting, or proteomics following cellular treatment with specific agents.
Genetic variants and their impact can be determined using structural models and functional assays comparing wild-type and mutant proteins.
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