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Recombinant Cynomolgus CA12 protein, His-tagged

Cat.No. : CA12-1456C
Product Overview : Recombinant Cynomolgus CA12 protein(A0A2K5TSB2)(Ala25-Gly299), fused with C-terminal His tag, was expressed in HEK293.
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Source : HEK293
Species : Cynomolgus
Tag : C-His
Protein length : Ala25-Gly299
Form : Lyophilized from 0.22μm filtered solution in PBS (pH 7.4). Normally 8% trehalose is added as protectant before lyophilization.
Bio-activity : Measured by its esterase activity. The specific activity is > 50 pmol/min/μg.
Molecular Mass : The protein has a predicted MW of 32.04 kDa. Due to glycosylation, the protein migrates to 40-50 kDa based on Tris-Bis PAGE result.
Endotoxin : Less than 1EU per μg by the LAL method.
Purity : > 95% as determined by Tris-Bis PAGE; > 95% as determined by HPLC.
Storage : Reconstituted protein stable at -80°C for 12 months, 4°C for 1 week. Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
Reconstitution : Centrifuge tubes before opening. Reconstituting to a concentration more than 100 μg/ml is recommended. Dissolve the lyophilized protein in distilled water.

Not For Human Consumption!

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Customer Reviews (3)

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12/20/2022

    Professional assistance, invaluable for complex protein experiments.

    05/09/2021

      Cost-effective quantitation, ideal for budget-conscious labs.

      11/21/2020

        Impressive expertise, accelerates our research progress.

        Q&As (7)

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        Are there any known inhibitors specific to CA12, and how do they impact its enzymatic function? 07/13/2021

        Known inhibitors can be identified through drug screening assays, and their impact on CA12 can be studied using kinetic studies and cell-based assays.

        In which specific cellular compartments is CA12 predominantly localized, and how does this localization influence its role? 06/12/2020

        Cellular localization can be identified using immunofluorescence, subcellular fractionation, or electron microscopy.

        What role does CA12 play in tumorigenesis, especially in hypoxic tumor environments? 08/29/2019

        CA12 has been implicated in tumor progression, particularly in hypoxic environments, by modulating pH and thus influencing tumor cell survival and metastasis. This can be assessed using cellular assays and tumor models.

        What downstream signaling pathways are activated or inhibited by CA12? 07/28/2019

        Downstream pathways can be identified using pathway analysis tools, phosphoproteomics, and specific signal transduction assays.

        How does CA12 activity get modulated under varying pH conditions? 04/08/2018

        The activity modulation under different pH conditions can be determined using enzymatic assays and pH shift experiments.

        How does CA12 expression vary in response to different cellular stressors or stimuli? 03/08/2018

        Expression changes in response to stressors can be analyzed using techniques like qPCR, Western blotting, or proteomics following cellular treatment with specific agents.

        How do genetic variants of the CA12 gene influence its protein structure and function? 10/18/2017

        Genetic variants and their impact can be determined using structural models and functional assays comparing wild-type and mutant proteins.

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