Recombinant Human CA12 Protein
Cat.No. : | CA12-805H |
Product Overview : | Recombinant Human Carbonic Anhydrase XII, Variant 2 was expressed in Sf9 insect cells. |
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Description : | Carbonic anhydrases (CAs) are enzymes which catalyze the reversible hydration of carbon dioxide according to the following reaction: CO2 + H2O ↔ HCO3- + H+. The main function of this protein family is to regulate the acid-base balance, which is of a considerable biological importance. In addition, they participate in several other physiological functions including CO2 and HCO3- transport, bone resorption, production of biological fluids, ureagenesis, gluconeogenesis and lipogenesis. Carbonic anhydrases are metalloenzymes containing a zinc-atom in their active site. The expanding CA gene family includes at least 13 enzymatically active members with different structural and catalytic properties. His-tag removed. |
Source : | Insect cell |
Species : | Human |
Form : | 50 mM Tris-HCl pH 7.5 and 0.05 M NaN3, pH 7.5 |
Molecular Mass : | 30 kDa |
AASequence : | GS (residues remained after His-tag removal) APVNGSKWTYFGPDGENSWSKKYPS CGGLLQSPIDLHSDILQYDASLTPL EFQGYNLSANKQFLLTNNGHSVKLN LPSDMHIQGLQSRYSATQLHLHWGN PNDPHGSEHTVSGQHFAAELHIVHY NSDLYPDASTASNKSEGLAVLAVLI EMGSFNPSYDKIFSHLQHVKYKGQE AFVPGFNIEELLPERTAEYYRYRGS LTTPPCNPTVLWTVFRNPVQISQEQ LLALETALYCTHMDDPSPREMINNF RQVQKFDERLVYTSFSQ |
Purity : | > 95 % (SDS-PAGE under reducing conditions) |
Storage : | Store at -80 centigrade, avoid freeze/thaw cycles. |
Tag : | Non |
Gene Name : | CA12 carbonic anhydrase XII [ Homo sapiens ] |
Official Symbol : | CA12 |
Synonyms : | CAXII; CA-XII; T18816; HsT18816 |
Gene ID : | 771 |
mRNA Refseq : | NM_001218.4 |
Protein Refseq : | NP_001209.1 |
MIM : | 603263 |
UniProt ID : | O43570 |
Products Types
◆ Recombinant Protein | ||
CA12-1154M | Recombinant Mouse CA12 Protein, His (Fc)-Avi-tagged | +Inquiry |
CA12-423R | Recombinant Rhesus Macaque CA12 Protein, His (Fc)-Avi-tagged | +Inquiry |
CA12-0233H | Recombinant Human CA12 Protein, GST-Tagged | +Inquiry |
CA12-260M | Active Recombinant Mouse CA12 protein(Met1-Ser301), His-tagged | +Inquiry |
CA12-1456C | Recombinant Cynomolgus CA12 protein, His-tagged | +Inquiry |
◆ Lysates | ||
CA12-3067MCL | Recombinant Mouse CA12 cell lysate | +Inquiry |
CA12-3061HCL | Recombinant Human CA12 cell lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Customer Reviews (3)
Write a reviewProfessional assistance, invaluable for complex protein experiments.
Cost-effective quantitation, ideal for budget-conscious labs.
Impressive expertise, accelerates our research progress.
Q&As (7)
Ask a questionKnown inhibitors can be identified through drug screening assays, and their impact on CA12 can be studied using kinetic studies and cell-based assays.
Cellular localization can be identified using immunofluorescence, subcellular fractionation, or electron microscopy.
CA12 has been implicated in tumor progression, particularly in hypoxic environments, by modulating pH and thus influencing tumor cell survival and metastasis. This can be assessed using cellular assays and tumor models.
Downstream pathways can be identified using pathway analysis tools, phosphoproteomics, and specific signal transduction assays.
The activity modulation under different pH conditions can be determined using enzymatic assays and pH shift experiments.
Expression changes in response to stressors can be analyzed using techniques like qPCR, Western blotting, or proteomics following cellular treatment with specific agents.
Genetic variants and their impact can be determined using structural models and functional assays comparing wild-type and mutant proteins.
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