• Official Full Name

    cell adhesion molecule 2

  • Overview

    This gene encodes a member of the synaptic cell adhesion molecule 1 (SynCAM) family which belongs to the immunoglobulin;(Ig) superfamily. The encoded protein has three Ig-like domains and a cytosolic protein 4.1 binding site near the;C-terminus. Proteins belonging to the protein 4.1 family crosslink spectrin and interact with other cytoskeletal;proteins. Multiple transcript variants encoding different isoforms have been found for this gene.
  • Synonyms

    CADM2; cell adhesion molecule 2; IGSF4D, immunoglobulin superfamily, member 4D; Necl 3; NECL3; nectin like 3; SynCAM2; nectin-like 3; nectin-like protein 3; immunoglobulin superfamily member 4D; immunoglobulin superfamily, member 4D; IGSF4D; Necl-3; synC;

  • Recombinant Proteins
  • Protein Pre-coupled Magnetic Beads
  • Human
  • Mouse
  • Rat
  • E.coli
  • HEK293
  • Human Cell
  • Mammalian Cell
  • Mammalian cells
  • Fc
  • His
  • His (Fc)
  • Avi
  • N/A
  • N
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human CADM2-357H Active Recombinant Human CADM2 Mammalian cells N/A
Human CADM2-5605H Active Recombinant Human Cell Adhesion Molecule 2, His-tagged Mammalian cells His
Human CADM2-648H Active Recombinant Human CADM2, Fc-tagged, Biotinylated Human Cell Fc
Human CADM2-649H Active Recombinant Human CADM2, Fc-tagged Human Cell Fc
Human CADM2-10652H Recombinant Human CADM2, His-tagged E.coli His 28-404a.a.
Human CADM2-714H Recombinant Human CADM2 Protein, His-tagged HEK293 His
Human CADM2-354H Recombinant Human CADM2 Protein, His-tagged E.coli N-His Gln25-Ile435
Human CADM2-2583H Recombinant Human CADM2 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Human CADM2-2583H-B Recombinant Human CADM2 Protein Pre-coupled Magnetic Beads HEK293
Mouse CADM2-2636M Recombinant Mouse CADM2 Protein Mammalian Cell His
Mouse CADM2-1183M Recombinant Mouse CADM2 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse CADM2-1183M-B Recombinant Mouse CADM2 Protein Pre-coupled Magnetic Beads HEK293
Rat CADM2-1080R Recombinant Rat CADM2 Protein Mammalian Cell His
Rat CADM2-744R-B Recombinant Rat CADM2 Protein Pre-coupled Magnetic Beads HEK293
Rat CADM2-744R Recombinant Rat CADM2 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • Other Resource

CADM2 involved in several pathways and played different roles in them. We selected most pathways CADM2 participated on our site, such as Adherens junctions interactions, Cell junction organization, Cell-Cell communication, which may be useful for your reference. Also, other proteins which involved in the same pathway with CADM2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Adherens junctions interactionsCDH13;PVRL1A;CDH10A;CDH6;CDH24;CTNNB2;CADM2B;PTBP3;JUPA
Cell junction organizationCDH18A;CLDN23;CADM2A;CDH12A;CDH18;PLECA;FERMT2;FBLIM1;CDH10
Cell-Cell communicationCLDN16;CDH12A;CD151;TESK1;CDH9;KIRREL2;CDH6;CLDN20;CDH10
Cell-cell junction organizationCDH18;CDH10;CLDN23;CDH10A;INADL;ANG;CLDN20;CLDN4;CDH9

CADM2 has several biochemical functions, for example, cell adhesion molecule binding, protein homodimerization activity, receptor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by CADM2 itself. We selected most functions CADM2 had, and list some proteins which have the same functions with CADM2. You can find most of the proteins on our site.

Function Related Protein
cell adhesion molecule bindingPTPRD;NLGN2;CADM1;NPTN;PVRL4;PVRL3B;ITGB2;POSTN;POSTNB
protein homodimerization activityKLHL7;BAXB;MGLL;OXA1L;TYW5;GSTM7;GNPTG;FAM109A;PTPRE
receptor bindingDRD1A;ARPP19;H2-Q10;GDNF;MSTN;F2R;TDGF1;STOML2;CADM4

CADM2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CADM2 here. Most of them are supplied by our site. Hope this information will be useful for your research of CADM2.

  • Q&As
  • Reviews

Q&As (5)

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How does CADM2 contribute to tissue-specific adhesion and recognition in the immune system, and what implications does this have for vaccine development or immunotherapy? 08/31/2022

CADM2's role in immune cell adhesion and recognition is relevant to vaccine development and immunotherapy strategies, as it influences immune cell interactions and responses.

How does CADM2's expression change during development, and what are its roles in tissue development and differentiation? 10/02/2021

CADM2 expression varies during development and contributes to tissue development and cellular differentiation, particularly in the nervous system

Can you explain the significance of CADM2 in neural cell adhesion and synaptic plasticity, particularly in the context of neurological disorders? 07/15/2020

CADM2 is essential for neural cell adhesion and synaptic plasticity, contributing to the formation and maintenance of neural connections. Dysregulation of CADM2 has been linked to neurological disorders like schizophrenia and autism spectrum disorders.

How does CADM2 contribute to immune responses, and what is its role in autoimmune diseases or cancer immunology? 04/23/2019

CADM2 plays a role in immune cell interactions and modulates immune responses. Its involvement in autoimmune diseases and cancer immunology is an area of ongoing research.

What are the known post-translational modifications of CADM2, and how do they influence its function in cellular adhesion and signaling pathways? 12/06/2018

Post-translational modifications, such as phosphorylation and glycosylation, modulate CADM2's interactions and functions, affecting cellular adhesion and signaling pathways.

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