Active Recombinant Human CADM2, Fc-tagged, Biotinylated

• Cat.No.: CADM2-648H
• Product Overview: The recombinant human NECL3-Fc fusion protein is expressed as a 572-amino acid protein consisting of Gln25 - His367 region of NECL3 (UniProt accession #Q8N3J6) and a C-terminal Fc from human IgG1, which exists as a dimer under non-reducing conditions.

Specification

• Source: Human cells
• Species: Human
• Tag: Fc
• Form: Supplied at 0.5 mg/ml in sterile PBS pH7.4 (carrier & preservative free). The purified recombinant protein was labeled with Biotin (3-5 Biotin per molecule).
• Bio-activity: Enhances neurite outgrowth of E16-E18 rat embryonic cortical neurons
• Molecular Mass: Calculated molecular mass (kDa): 63.2; Estimated by SDS-PAGE under reducing condition (kDa): 80-65
• AA Sequence: QFPLTQNVTVVEGGTAILTCRVDQN DNTSLQWSNPAQQTLYFDDKKALRD NRIELVRASWHELSISVSDVSLSD EGQYTCSLFTMPVKTSKAYLTVLGV PEKPQISGFSSPVMEGDLMQLTCKT SGSKPAADIRWFKNDKEIKDVKYL KEEDANRKTFTVSSTLDFRVDRSDD GVAVICRVDHESLNATPQVAMQVLE IHYTPSVKIIPSTPFPQEGQPLIL TCESKGKPLPEPVLWTKDGGELPDP DRMVVSGRELNILFLNKTDNGTYRC EATNTIGQSSAEYVLIVHDVPNTL LPTTIIPSLTTATVTTTVAITTSPT TSATTSSIRDPNALAGQNGPDHGST GTHTCPPCPAPELLGGPSVFLFPP KPKDTLMISRTPEVTCVVVDVSHED PEVKFNWYVDGVEVHNAKTKPREEQ YNSTYRVVSVLTVLHQDWLNGKEY KCKVSNKALPAPIEKTISKAKGQPR EPQVYTLPPSREEMTKNQVSLTCLV KGFYPSDIAVEWESNGQPENNYKT TPPVLDSDGSFFLYSKLTVDKSRWQ QGNVFSCSVMHEALHNHYTQKSLSL SPGK
• Endotoxin: <0.1 eu per 1 μg of purified recombinant protein determined by the lal>
• Purity: >95% judged by SDS-PAGE under reducing condition
• Storage: The product is shipped at 4°C. Upon receipt, centrifuge the product briefly before opening the vial. It is recommended to store small aliquots at the temperature below –20°C for long-term storage and the product is stable for 3 months. The undiluted protein can be stored at 4°C for no more than 2 weeks. Avoid repeated freeze-thaw cycles.
• Protein length: Gln25-His367

Gene Information

• Gene Name: CADM2 cell adhesion molecule 2 [ Homo sapiens ]
• Official Symbol: CADM2
• Synonyms: CADM2; cell adhesion molecule 2; IGSF4D, immunoglobulin superfamily, member 4D; Necl 3; NECL3; nectin like 3; SynCAM2; nectin-like 3; nectin-like protein 3; immunoglobulin superfamily member 4D; immunoglobulin superfamily, member 4D; IGSF4D; Necl-3; synCAM2; MGC104534; MGC138341; MGC138343
• Gene ID: 253559
• mRNA Refseq: NM_001167674
• Protein Refseq: NP_001161146
• MIM: 609938
• UniProt ID: Q8N3J6
• Chromosome Location: 3p12.2
• Pathway: Adherens junctions interactions, organism-specific biosystem; Cell junction organization, organism-specific biosystem; Cell-Cell communication, organism-specific biosystem; Cell-cell junction organization, organism-specific biosystem

Reviews

11/09/2021

This is hands down the best product I've ever tried.

06/29/2020

It's made a significant difference in my workouts and recovery time.

04/17/2019

I've been using the product for a few months now, and it has exceeded my expectations.

Q&As

How does CADM2 contribute to tissue-specific adhesion and recognition in the immune system, and what implications does this have for vaccine development or immunotherapy?

CADM2's role in immune cell adhesion and recognition is relevant to vaccine development and immunotherapy strategies, as it influences immune cell interactions and responses.

How does CADM2's expression change during development, and what are its roles in tissue development and differentiation?

CADM2 expression varies during development and contributes to tissue development and cellular differentiation, particularly in the nervous system

Can you explain the significance of CADM2 in neural cell adhesion and synaptic plasticity, particularly in the context of neurological disorders?

CADM2 is essential for neural cell adhesion and synaptic plasticity, contributing to the formation and maintenance of neural connections. Dysregulation of CADM2 has been linked to neurological disorders like schizophrenia and autism spectrum disorders.

How does CADM2 contribute to immune responses, and what is its role in autoimmune diseases or cancer immunology?

CADM2 plays a role in immune cell interactions and modulates immune responses. Its involvement in autoimmune diseases and cancer immunology is an area of ongoing research.

What are the known post-translational modifications of CADM2, and how do they influence its function in cellular adhesion and signaling pathways?

Post-translational modifications, such as phosphorylation and glycosylation, modulate CADM2's interactions and functions, affecting cellular adhesion and signaling pathways.