Active Recombinant Human Cell Adhesion Molecule 2, His-tagged

• Cat.No.: CADM2-5605H
• Product Overview: Recombinant Human CADM2protein was expressed in Murine myeloma cell line with a C-terminal 6-His tag.Ala21-Asp335.

Specification

• Species: Human
• Source: Mammalian Cells
• Tag: His
• Protein Length: 21-335 a.a.
• Description: CADM2 is animmunoglobulin super family member that is also designated as synaptic celladhesion molecule 2 and nectin-like protein 3. The four CADM2 proteins,designated A, B, C and D, are type I transmembrane glycoproteins expressedmainly in epithelial cells that contain one V-type Ig-like and two C2-typeIg-like domains in their extracellular regions. These domains arecharacteristically responsible for Ca2+ independent homophilic andheterophilic interactions in the brain, lung, kidney, bladder, prostate andtestis.
• Form: Lyophilized from a0.2 μm filtered solution in PBS.
• N-terminalSequence: Ala21
• Molecular Weight: 35.5 kDa
• Activity: Measuredby its ability to enhance neurite outgrowth of E16-E18 rat embryonic corticalneurons. Able to significantly enhance neurite outgrowth when immobilized asa 3 μL droplet containing 50 ng on a nitrocellulose-coated microplate.
• Endotoxin Level: <1.0 EUper 1 μg of the protein by the LAL method.
• SDS-PAGE: 36-55kDa, reducing conditions
• Purity: >95%,by SDS-PAGE under reducing conditions and visualized by silver stain.
• Reconstitution: Reconstituteat 100 μg/mL in sterile PBS
• Storage: Use a manualdefrost freezer and avoid repeated freeze-thaw cycles. 12 months from date ofreceipt, -20 to -70°C as supplied. 1 month, 2 to 8 °C under sterile conditionsafter reconstitution. 3 months, -20 to -70°C under sterile conditions after reconstitution.

Gene Information

• Gene Name: CADM2 cell adhesion molecule 2[ Homo sapiens ]
• Official Symbol: CADM2
• Synonyms: CADM2; cell adhesionmolecule 2; NECL3; IGSF4D; Necl-3; synCAM2; nectin-like 3; nectin-likeprotein 3; immunoglobulin superfamily member 4D; immunoglobulin superfamily,member 4D; MGC104534; MGC138341; MGC138343; OTTHUMP00000213814;OTTHUMP00000213815; OTTHUMP00000213816; SYNCAM2
• Gene ID: 253559
• mRNA Refseq: NM_001167674
• Protein Refseq: NP_001161146
• MIM: 609938
• UniProt ID: Q8N3J6
• Chromosome Location: 3p12.2
• Pathway: Adherens junctionsinteractions; Cell junction organization; Cell-Cell communication; Cell-celljunction organization
• Function: adherens junctionorganization; cell junction assembly; cell-cell junction organization