| Official Full Name | coactivator-associated arginine methyltransferase 1 |
| Background | Protein arginine N-methyltransferases, such as CARM1, catalyze the transfer of a methyl group from;S-adenosyl-L-methionine to the side chain nitrogens of arginine residues within proteins to form methylated arginine;derivatives and S-adenosyl-L-homocysteine. Protein arginine methylation has been implicated in signal transduction,;metabolism of nascent pre-RNA, and transcriptional activation (Frankel et al., 2002 (PubMed 11724789)). |
| Synonyms | CARM1; coactivator-associated arginine methyltransferase 1; histone-arginine methyltransferase CARM1; PRMT4; protein arginine N-methyltransferase 4 |
| Species | Cat.# | Product name | Source (Host) | Tag | Protein Length | Price |
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carm1 involved in several pathways and played different roles in them. We selected most pathways carm1 participated on our site, such as Activation of gene expression by SREBF (SREBP), Androgen receptor signaling pathway, BMAL1:CLOCK,NPAS2 activates circadian gene expression, which may be useful for your reference. Also, other proteins which involved in the same pathway with carm1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Activation of gene expression by SREBF (SREBP) | NFYBB; SREBF2; CREBBP; PMVK; CYP51A1; MTF1; DHCR7; NFYBA; HELZ2; CARM1 |
| Androgen receptor signaling pathway | RUNX2A; KAT7B; GNB2L1; RNF14; TGFB1I1; POU2F1B; SVILA; RNF6; DAXX; RNF4 |
| BMAL1:CLOCK,NPAS2 activates circadian gene expression | DBP; NAMPT; CRY1; HELZ2; CRY2; NRIP1; NCOA2; CREBBP; CARM1 |
| Chromatin modifying enzymes | SMARCD3B; GATAD2A; KDM5D; SMYD3; MBD3; SETD3; DR1; SUZ12A; PADI2; MORF4L1 |
| Chromatin organization | ANO9A; BRD1; PHF15; PADI2; ARID4A; CHD4; PBRM1; YEATS4; PADI1; JHDM1D |
| Circadian Clock | CPT1A; CARM1; DBP; CRY2; RAI1; NAMPT; CSNK1E; HELZ2; NRIP1; CRY1 |
| Coregulation of Androgen receptor activity | CTDSP2; CARM1; CMTM2A; NRIP1; TMF1; TGFB1I1; PA2G4; KDM3A; SVIL; TCF4 |
| Developmental Biology | SALL4; DNM1; SHB; SDCBP; FRS2A; COL6A3; COL9A1B; DLG3; CDK19; UNC5D |
carm1 has several biochemical functions, for example, beta-catenin binding, histone methyltransferase activity, histone methyltransferase activity (H3-R17 specific). Some of the functions are cooperated with other proteins, some of the functions could acted by carm1 itself. We selected most functions carm1 had, and list some proteins which have the same functions with carm1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| beta-catenin binding | PXN; GLI3; BTRC; MED12; SHROOM2; PTBP3; KDM6B; TCF7L2; NUMB; CDH1 |
| histone methyltransferase activity | EED; PRDM13; PRMT1; CARM1; SUZ12; SUV39H1; PRMT2; EZH2; PRMT6 |
| histone methyltransferase activity (H3-R17 specific) | CARM1 |
| histone-arginine N-methyltransferase activity | PRMT3; PRMT2; PRMT5; PRMT8; CARM1; PRMT6; PRMT7 |
| ligand-dependent nuclear receptor transcription coactivator activity | SFR1; DCAF6; MED24; PSMC3IP; LRP2BP; ACTN4; PPARG; TSG101; ZCCHC18; PRKCBB |
| lysine-acetylated histone binding | TRIM24; PSME4; BAZ2A; ATAD2B; BRD3; PSME4B; MLL1; BAZ1B; TAF1; CARM1 |
| protein binding | GFM1; PCK2; VSNL1; ACAN; CACNG1; RTN4R; CNEP1R1; TMEM119; TLX1; RSPH3 |
| protein homodimerization activity | RQCD1; CREB3; Fzd4; IL6ST; PLEKHB1; PDE2A; MID2; PEX7; STC2; GZMA |
| protein methyltransferase activity | PRMT1; CARM1; NDUFAF5; NTMT1; METTL21A; METTL8; TRMT10B; DIMT1; RNMTL1A; TRMT10C |
| protein-arginine N-methyltransferase activity | METTL21A; PRMT8B; FAM86; METTL23; TRMT10C; FBXO11; METTL7B; PRDM11; METTL8; CARM1 |
| protein-arginine omega-N asymmetric methyltransferase activity | PRMT6; CARM1; PRMT1; PRMT2; PRMT3; PRMT8B; PRMT8; PRMT7 |
| transcription coactivator activity | SNW1; RB1; TRIM32; Ankar; MED26; ING4; TFAP2A; SCAND1; CITED2; TCERG1 |
| transcription regulatory region DNA binding | ZNF831; NKX3-1; NKX2; PPARG; ZNF821; ZBTB14; TOMM20A; FOS; DLX5; MTERF3 |
carm1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with carm1 here. Most of them are supplied by our site. Hope this information will be useful for your research of carm1.
SMARCC1; CEBPB; CEBPB; NUDT21; DNAJA3; QKI; ORF; NRIP1; HNRNPK; UBE2I
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