|Official Full Name||carbonyl reductase 1|
|Background||Carbonyl reductase is one of several monomeric, NADPH-dependent oxidoreductases having wide specificity for carbonyl compounds. This enzyme is widely distributed in human tissues. Another carbonyl reductase gene, CRB3, lies close to this gene on chromosome 21q.|
|Synonyms||CBR1; carbonyl reductase 1; CBR; carbonyl reductase [NADPH] 1; SDR21C1; short chain dehydrogenase/reductase family 21C; member 1; carbonyl reductase (NADPH) 1; prostaglandin 9-ketoreductase; prostaglandin-E(2) 9-reductase; NADPH-dependent carbonyl reducta|
|Species||Cat.#||Product name||Source (Host)||Tag||Protein Length||Price|
cbr1 involved in several pathways and played different roles in them. We selected most pathways cbr1 participated on our site, such as Arachidonic acid metabolism, Metabolism of xenobiotics by cytochrome P, Metabolic pathways, which may be useful for your reference. Also, other proteins which involved in the same pathway with cbr1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
|Pathway Name||Pathway Related Protein|
|Arachidonic acid metabolism||PLA2G2A; CYP4F18; ALOX5AP; ALOX5; CYP4F14; ALOX8; PLA2G4C; PLA2G5; PTGS1; CYP4F2|
|Metabolism of xenobiotics by cytochrome P||UGT1A6B; UGT1A9; UGT2B15; CYP1A; ALDH3A1; GSTM1; MGST2; UGT2A3; GSTA3; MGST1.2|
|Metabolic pathways||ABP1; NADK2; GAPDH; SORD; TKTB; PGAM1; GRHPRB; DGAT2; CKMT2; CRLS1|
|Chemical carcinogenesis||CYP3A43; CYP3A5; UGT2A2; CCBL1; ADH2-1; UGT1A4; UGT2B7; GSTA3; ADH1A; EPHX1|
cbr1 has several biochemical functions, for example, 15-hydroxyprostaglandin dehydrogenase (NADP+) activity, carbonyl reductase (NADPH) activity, oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor. Some of the functions are cooperated with other proteins, some of the functions could acted by cbr1 itself. We selected most functions cbr1 had, and list some proteins which have the same functions with cbr1. You can find most of the proteins on our site.
|15-hydroxyprostaglandin dehydrogenase (NADP+) activity||CBR1|
|carbonyl reductase (NADPH) activity||CBR2; DHRS2; CBR3; DHRS4; CBR1|
|oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor||DCXR; AKR1C21; AKR1C6; NDUFS7; DHRS4; CBR1; AKR1C4; AKR1C2; AKR1C3|
|prostaglandin-E2 9-reductase activity||CBR1|
cbr1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with cbr1 here. Most of them are supplied by our site. Hope this information will be useful for your research of cbr1.
PRKAB1; EIF1B; EPB41; VDAC1; NME2; MCC; HLA-B; HLA-C; EIF6; GABARAPL2; IKBKE; ATG101; DDA1; UBA5; FTSJ1; TNIK; TRAF6; EGFR; ERCC8