cbr1
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  • Official Full Name
  • carbonyl reductase 1
  • Background
  • Carbonyl reductase is one of several monomeric, NADPH-dependent oxidoreductases having wide specificity for carbonyl compounds. This enzyme is widely distributed in human tissues. Another carbonyl reductase gene, CRB3, lies close to this gene on chromosome 21q.
  • Synonyms
  • CBR1; carbonyl reductase 1; CBR; carbonyl reductase [NADPH] 1; SDR21C1; short chain dehydrogenase/reductase family 21C; member 1; carbonyl reductase (NADPH) 1; prostaglandin 9-ketoreductase; prostaglandin-E(2) 9-reductase; NADPH-dependent carbonyl reducta
Cat.#:CBR1-0467HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human CBR1 Protein, GST-Tagged
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Cat.#:CBR1-591HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human CBR1 Protein, His-tagged
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Cat.#:Cbr1-592MTag:His
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Cbr1 Protein, His-tagged
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Cat.#:Cbr1-593RTag:His
Source (Host):E. coliSpecies:Rat
Product nameRecombinant Rat Cbr1 Protein, His-tagged
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Cat.#:CBR1-143HTag:MYC/DDK
Source (Host):HEK293Species:Human
Product nameRecombinant Human CBR1, MYC/DDK-tagged
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Cat.#:CBR1-26326THTag:
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human CBR1 protein
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Cat.#:CBR1-26327THTag:
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human CBR1
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Cat.#:CBR1-1159RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat CBR1 Protein
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Cat.#:CBR1-2494CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken CBR1
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Cat.#:CBR1-9756ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish CBR1
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Cat.#:CBR1-142HTag:N/A
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human Carbonyl Reductase 1
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Cat.#:CBR1-288HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human CBR1 cell lysate
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Involved Pathway

CBR1 involved in several pathways and played different roles in them. We selected most pathways CBR1 participated on our site, such as Arachidonic acid metabolism, Metabolism of xenobiotics by cytochrome P, Metabolic pathways, which may be useful for your reference. Also, other proteins which involved in the same pathway with CBR1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Arachidonic acid metabolism
CBR1; FAM213B; CYP2C50; GPX5; CYP4F22; ALOX5; PTGIS; GPX8; EPHX2; CYP2J5
Metabolism of xenobiotics by cytochrome P
GSTM2; UGT2B15; GSTA5; GSTM5; CYP1A; UGT1A2; UGT1A6B; GSTAL; ALDH3B1; UGT1A3
Metabolic pathways
UGT2B7; HLCS; PLB1; SC5D; ST6GALNAC4; ATP6V1B1; POLR2J; NAGLU; CDIPT; GGT7
Chemical carcinogenesis
SULT1A1; CYP2C70; UGT1A6A; ADH4; SULT1A4; AHA-1; CYP2A13; UGT1A7; UGT1A9; FAM84B

Protein Function

CBR1 has several biochemical functions, for example, 15-hydroxyprostaglandin dehydrogenase (NADP+) activity, carbonyl reductase (NADPH) activity, oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor. Some of the functions are cooperated with other proteins, some of the functions could acted by CBR1 itself. We selected most functions CBR1 had, and list some proteins which have the same functions with CBR1. You can find most of the proteins on our site.
Function
Related Protein
Function 15-hydroxyprostaglandin dehydrogenase (NADP+) activity
Related Protein CBR1
Function carbonyl reductase (NADPH) activity
Related Protein DHRS2; CBR2; CBR1; DHRS4; CBR3
Function oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor
Related Protein AKR1C21; DCXR; AKR1C3; AKR1C2; AKR1C4; NDUFS7; AKR1C6; DHRS4; CBR1
Function prostaglandin-E2 9-reductase activity
Related Protein CBR1

Interacting Protein

CBR1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CBR1 here. Most of them are supplied by our site. Hope this information will be useful for your research of CBR1.
PRKAB1; EIF1B; EPB41; VDAC1; NME2; MCC; HLA-B; HLA-C; EIF6; GABARAPL2; IKBKE; ATG101; DDA1; UBA5; FTSJ1; TNIK; TRAF6; EGFR; ERCC8