Recombinant Human CBR1 Protein, GST-Tagged

• Cat.No.: CBR1-0467H
• Product Overview: Human CBR1 full-length ORF (AAH02511.1, 1 a.a. - 277 a.a.) recombinant protein with GST-tag at N-terminal.

Specification

• Description: The protein encoded by this gene acts as a homotetramer to catalyze the conversion of homocysteine to cystathionine, the first step in the transsulfuration pathway. The encoded protein is allosterically activated by adenosyl-methionine and uses pyridoxal phosphate as a cofactor. Defects in this gene can cause cystathionine beta-synthase deficiency (CBSD), which can lead to homocystinuria. This gene is a major contributor to cellular hydrogen sulfide production. Multiple alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Feb 2016]
• Source: Wheat Germ
• Species: Human
• Tag: GST
• Molecular Mass: 56.21 kDa
• AA Sequence: MSSGIHVALVTGGNKGIGLAIVRDL CRLFSGDVVLTARDVTRGQAAVQQL QAEGLSPRFHQLDIDDLQSIRALRD FLRKEYGGLDVLVNNAGIAFKVADP TPFHIQAEVTMKTNFFGTRDVCTEL LPLIKPQGRVVNVSSIMSVRALKSC SPELQQKFRSETITEEELVGLMNKF VEDTKKGVHQKEGWPSSAYGVTKIG VTVLSRIHARKLSEQRKGDKILLNA CCPGWVRTDMAGPKATKSPEEGAET PVYLALLPPDAEGPHGQFVSEKRVE QW
• Applications: Enzyme-linked Immunoabsorbent Assay
  Western Blot (Recombinant protein)
  Antibody Production
  Protein Array
• Storage: Store at -80 centigrade. Aliquot to avoid repeated freezing and thawing.
• Storage Buffer: 50 mM Tris-HCI, 10 mM reduced Glutathione, pH=8.0 in the elution buffer.

Gene Information

• Gene Name: CBR1 carbonyl reductase 1 [ Homo sapiens ]
• Official Symbol: CBR1
• Synonyms: CBR1; carbonyl reductase 1; CBR; carbonyl reductase [NADPH] 1; SDR21C1; short chain dehydrogenase/reductase family 21C; member 1; carbonyl reductase (NADPH) 1; prostaglandin 9-ketoreductase; prostaglandin-E(2) 9-reductase; NADPH-dependent carbonyl reductase 1; 15-hydroxyprostaglandin dehydrogenase; short chain dehydrogenase/reductase family 21C, member 1; hCBR1
• Gene ID: 873
• mRNA Refseq: NM_001757
• Protein Refseq: NP_001748
• MIM: 114830
• UniProt ID: P16152