Recombinant Human CBR1 Protein (2-277 aa), His-tagged

• Cat.No.: CBR1-1351H
• Product Overview: Recombinant Human CBR1 Protein (2-277 aa) is produced by Yeast expression system. This protein is fused with a 6xHis tag at the N-terminal. Research Area: Metabolism. Protein Description: Full Length of Mature Protein.

Specification

• Description: NADPH-dependent reductase with broad substrate specificity. Catalyzes the reduction of a wide variety of carbonyl compounds including quinones, prostaglandins, menadione, plus various xenobiotics. Catalyzes the reduction of the antitumor anthracyclines doxorubicin and daunorubicin to the cardiotoxic compounds doxorubicinol and daunorubicinol. Can convert prostaglandin E2 to prostaglandin F2-alpha. Can bind glutathione, which explains its higher affinity for glutathione-conjugated substrates. Catalyzes the reduction of S-nitrosoglutathione.
• Source: Yeast
• Species: Human
• Tag: His
• Form: Tris-based buffer,50% glycerol
• Molecular Mass: 32.2 kDa
• Protein length: 2-277 aa
• AA Sequence: SSGIHVALVTGGNKGIGLAIVRDLC RLFSGDVVLTARDVTRGQAAVQQLQ AEGLSPRFHQLDIDDLQSIRALRDF LRKEYGGLDVLVNNAGIAFKVADPT PFHIQAEVTMKTNFFGTRDVCTELL PLIKPQGRVVNVSSIMSVRALKSCS PELQQKFRSETITEEELVGLMNKFV EDTKKGVHQKEGWPSSAYGVTKIGV TVLSRIHARKLSEQRKGDKILLNAC CPGWVRTDMAGPKATKSPEEGAETP VYLALLPPDAEGPHGQFVSEKRVEQ W
• Purity: > 90% as determined by SDS-PAGE.
• Notes: Repeated freezing and thawing is not recommended. Store working aliquots at 4 centigrade for up to one week.
• Storage: The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself. Generally, the shelf life of liquid form is 6 months at -20 centigrade/-80 centigrade. The shelf life of lyophilized form is 12 months at -20 centigrade/-80 centigrade.
• Concentration: A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.

Gene Information

• Gene Name: CBR1 carbonyl reductase 1 [ Homo sapiens ]
• Official Symbol: CBR1
• Synonyms: CBR1; CBR; SDR21C1; hCBR1
• Gene ID: 873
• mRNA Refseq: NM_001757
• Protein Refseq: NP_001748
• MIM: 114830
• UniProt ID: P16152