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Official Full Name chromobox homolog 3
Background At the nuclear envelope, the nuclear lamina and heterochromatin are adjacent to the inner nuclear membrane. The protein encoded by this gene binds DNA and is a component of heterochromatin. This protein also can bind lamin B receptor, an integral membrane protein found in the inner nuclear membrane. The dual binding functions of the encoded protein may explain the association of heterochromatin with the inner nuclear membrane. This protein binds histone H3 tails methylated at Lys-9 sites. This protein is also recruited to sites of ultraviolet-induced DNA damage and double-strand breaks. Two transcript variants encoding the same protein but differing in the 5 UTR, have been found for this gene.[provided by RefSeq, Mar 2011]
Synonyms CBX3; chromobox homolog 3; HECH; HP1-GAMMA; HP1Hs-gamma; chromobox protein homolog 3; HP1 gamma homolog; modifier 2 protein; heterochromatin-like protein 1; heterochromatin protein HP1 gamma; heterochromatin protein 1 homolog gamma; chromobox homolog 3 (HP1 gamma homolog, Drosophila);
    • Species :
    • Chicken
    • Human
    • Mouse
    • Rhesus Macaque
    • Source :
    • E.coli
    • HEK293
    • HEK293T
    • Mammalian Cell
    • Wheat Germ
    • Tag :
    • GST
    • His
    • MYC/DDK
    • Myc
    • DDK
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human CBX3-10768H Recombinant Human CBX3, His-tagged E.coli His
    Human CBX3-268H Recombinant Human CBX3 protein, GST-tagged Wheat Germ GST
    Human CBX3-269H Recombinant Human CBX3 protein, His-tagged E.coli His
    Human CBX3-270H Recombinant Human CBX3 protein, MYC/DDK-tagged HEK293 Myc/DDK
    Human CBX3-27362TH Recombinant Human CBX3 N/A
    Human CBX3-6522H Recombinant Human CBX3 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
    Human CBX3-7804HCL Recombinant Human CBX3 293 Cell Lysate HEK293 N/A
    Human CBX3-7805HCL Recombinant Human CBX3 293 Cell Lysate HEK293 N/A
    Mouse Cbx3-595M Recombinant Mouse Cbx3 Protein, His-tagged E.coli His
    Mouse Cbx3-793M Recombinant Mouse Cbx3 Protein, MYC/DDK-tagged HEK293T MYC/DDK
    Rhesus Macaque CBX3-647R Recombinant Rhesus monkey CBX3 Protein, His-tagged Mammalian Cell His
    Chicken CBX3-6211C Recombinant Chicken CBX3 Mammalian Cell His

    cbx3 involved in several pathways and played different roles in them. We selected most pathways cbx3 participated on our site, such as Diurnally regulated genes with circadian orthologs, Gene Expression, RNA Polymerase I Chain Elongation, which may be useful for your reference. Also, other proteins which involved in the same pathway with cbx3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Diurnally regulated genes with circadian orthologs NCKAP1; QK; RBPMS; TOB1; CEBPB; NR1D2; STBD1; PURA; G0S2; ZFR
    Gene Expression HNRNPA2B1; TH1L; SF3B2; EEF1E1; EED; ZNF75A; ZKSCAN5; MAPKAPK2B; ZNF143A; ZNF222
    RNA Polymerase I Chain Elongation TAF1C; TAF1A; CD3EAP; CBX3; TAF1B; UBTF; EFCAB11; TAF1D; CBX3A
    RNA Polymerase I Transcription MTA1; GATAD2B; GATAD2AB; EFCAB11; TAF1C; TAF1A; CD3EAP; MTA2; CBX3A; TAF1D
    RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription CBX3; BRF1; NFIC; CRCP; ZNF143; GATAD2AB; GATAD2B; TFB2M; ZNF143A; GATAD2A

    cbx3 has several biochemical functions, for example, enzyme binding, histone methyltransferase binding, identical protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by cbx3 itself. We selected most functions cbx3 had, and list some proteins which have the same functions with cbx3. You can find most of the proteins on our site.

    Function Related Protein
    enzyme binding HIST1H2AE; RPS19BP1; DNM2; DIS3L; TULP3; MAPT; PARK2; AKIRIN2; HIF1A; CALU
    histone methyltransferase binding CBX1; NOP56; PRDM4; CBX3
    identical protein binding CHMP4A; CDC42BPA; MVK; B2M; TRAF2; S100B; MBIP; GOT2B; NOD1; KIRRELA
    protein binding TTK; SCGB2A2; SMURF1; DCDC2B; DYM; ARF1; ARHGAP4; HPRT1; DVL1; SGOL2
    protein domain specific binding KCTD13; ARFIP2B; SCN5A; UNC13A; YWHAE2; PPP3R1; SHROOM2; NFASC; IKBKG; RAPGEF3

    cbx3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with cbx3 here. Most of them are supplied by our site. Hope this information will be useful for your research of cbx3.

    TRIM28; HIST1H3D; LBR; Mis12; Mad2l2

    Ren, CY; Morohashi, K; et al. Small-Molecule Modulators of Methyl-Lysine Binding for the CBX7 Chromodomain. CHEMISTRY & BIOLOGY 22:161-168(2015).
    Tsui, KH; Lin, LT; et al. Gene expression of cumulus cells in women with poor ovarian response after dehydroepiandrosterone supplementation. Taiwanese Journal of Obstetrics & Gynecology 53:559-565(2014).

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