CCK involved in several pathways and played different roles in them. We selected most pathways CCK participated on our site, such as Class A/1 (Rhodopsin-like receptors), G alpha (q) signalling events, GPCR downstream signaling, which may be useful for your reference. Also, other proteins which involved in the same pathway with CCK were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name |
Pathway Related Protein |
| Class A/1 (Rhodopsin-like receptors) |
NMUR1; ZFPM2B; PRLH; PMCH; NMS; CHRM4; HRH3; CNR2; NMU; AGTR1 |
| G alpha (q) signalling events |
NPFF; PMCH; NMB; LPAR5A; FPR-RS6; OXTRL; GRP; CHRM5; DGKQ; RGS21 |
| GPCR downstream signaling |
CCL27; LPAR2B; LPAR5A; RGS14; OPN4; INSL5; CRHR1; SSTR3; CALCB; ADORA2A |
| GPCR ligand binding |
OXTRL; CXCR6; QRFP; LPAR1; CRHB; RAMP1; PTH2; TAAR1; SSTR2; NTS |
| Gastrin-CREB signalling pathway via PKC and MAPK |
GPR65; DGKQ; CASR; TAC1; PROK1; NPS; TAE1; GPR132; LPAR2A; HCRT |
| Peptide ligand-binding receptors |
HEBP1; OXTRL; QRFP; ZFPM2B; CCRL2; APLN; AMCF-II; GPR37L1; GPR77; NMS |
| Signal Transduction |
AES; FSTL1B; LGR4; TAGAP1; ARHGAP29; SCT; IGF2BP1; CDC42EP1B; RAMP2; PRLH |
| Signaling by GPCR |
OR2AP1; RGS1; PROK1; ARHGEF3; PROKR1; S1PR5B; SST1.1; GPRC6A; GPR31; RGS6 |
CCK has several biochemical functions, for example, hormone activity, neuropeptide hormone activity, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by CCK itself. We selected most functions CCK had, and list some proteins which have the same functions with CCK. You can find most of the proteins on our site.
| Function |
Related Protein |
| hormone activity |
STC1L; PPY; PTHLH; PTH; FNDC5B; CRHB; UCN3; INHBAB; INSB; GALP |
| neuropeptide hormone activity |
AGRP; NPY; VIP; CORT; QRFP; HCRT; PYYA; NTS; GRP; GAL |
| protein binding |
PLIN5; RBMX; KIF18A; YWHAH; THOP1; GBP2; RPA2; HIST4H4; DVL3; ZNF703 |
CCK has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CCK here. Most of them are supplied by our site. Hope this information will be useful for your research of CCK.
Czeh, B; Varga, ZKK; et al. Chronic Stress Reduces the Number of GABAergic Interneurons in the Adult Rat Hippocampus, Dorsal-Ventral and Region-Specific Differences. HIPPOCAMPUS 25:393-405(2015).
Liu, GH; Du, PJ; et al. Myeloid Differentiation Factor 88 Promotes Cisplatin Chemoresistance in Ovarian Cancer. CELL BIOCHEMISTRY AND BIOPHYSICS 71:963-969(2015).
