CCNE2
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Official Full Name
cyclin E2
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Overview
The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin forms a complex with and functions as a regulatory subunit of CDK2. This cyclin has been shown to specifically interact with CIP/KIP family of CDK inhibitors, and plays a role in cell cycle G1/S transition. The expression of this gene peaks at the G1-S phase and exhibits a pattern of tissue specificity distinct from that of cyclin E1. A significantly increased expression level of this gene was observed in tumor-derived cells. -
Synonyms
CCNE2; cyclin E2; G1/S-specific cyclin-E2; CYCE2;
- Recombinant Proteins
- Cell & Tissue Lysates
- Chicken
- Human
- Zebrafish
- E.coli
- HEK293
- In Vitro Cell Free System
- Insect Cell
- Mammalian Cell
- Wheat Germ
- GST
- His
- N/A
- T7
Species | Cat.# | Product name | Source (Host) | Tag | Protein Length | Price |
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Human | CCNE2-10864H | Recombinant Human CCNE2, GST-tagged | E.coli | GST | 1-374a.a. | |
Human | CCNE2-0667H | Recombinant Human CCNE2 Protein, GST-Tagged | Wheat Germ | GST | ||
Human | CCNE2-2918H | Recombinant Human Cyclin E2, T7-tagged | E.coli | T7 | ||
Human | CCNE2-180H | Recombinant Human CCNE2 protein, GST-tagged | Insect Cell | GST | ||
Human | CCNE2-7709HCL | Recombinant Human CCNE2 293 Cell Lysate | HEK293 | N/A | ||
Human | CCNE2-2774H | Recombinant Human CCNE2 protein, His-tagged | E.coli | His | 1-141 aa | |
Human | CCNE2-2972HF | Recombinant Full Length Human CCNE2 Protein, GST-tagged | In Vitro Cell Free System | GST | 374 amino acids | |
Human | CCNE2-3047H | Recombinant Human CCNE2 protein, His-tagged | E.coli | His | 1-374 aa | |
Zebrafish | CCNE2-307Z | Recombinant Zebrafish CCNE2 | Mammalian Cell | His | ||
Chicken | CCNE2-2634C | Recombinant Chicken CCNE2 | Mammalian Cell | His |
- Involved Pathway
- Protein Function
- Interacting Protein
- CCNE2 Related Articles
- CCNE2 Related Research Area
- CCNE2 Related Signal Pathway
CCNE2 involved in several pathways and played different roles in them. We selected most pathways CCNE2 participated on our site, such as Cell cycle, Oocyte meiosis, p signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with CCNE2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name | Pathway Related Protein |
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Cell cycle | DYRK1A;YWHAQ;SYNE1;ARF1;E2F2;ORC6;INCENP;HTATIP;SKA2 |
Oocyte meiosis | SMC3;CCNE1;CPEB1B;CALM;CPEB1A;ITPR1;CAMK2G1;CDC26;INSB |
p signaling pathway | TNFRSF10B;CYCS;BIDA;LRDD;Casp3;SHISA5;PTENA;CASP9;CCNG1 |
PIK-Akt signaling pathway | G6PC;IL6R;Fgf15;HSP90B1;PKN2;IL2RG;ITGA5;IFNA17;PDGFC |
Hepatitis B | IFNA8;CCNA2;IFNA12;PIK3R2;IKBKG;SRC;RAF1;BIRC5;FADD |
Measles | EIF3H;NFKBIA;IFIH1;PIK3R1;EIF2AK3;RAB9A;HSPA1A;RAB9B;CCNE2 |
Pathways in cancer | PLCB4;BID;MMP1A;AXIN1;LPAR3;FGF19;WNT2B;CDH1;LPAR6 |
Viral carcinogenesis | HIST1H4J;HIST2H4;CREB3L1;HLA-C;DLG1;TP53;MAPKAPK2;HIST1H2BD;GTF2A1L |
MicroRNAs in cancer | Abcb1b;NOTCH4;CYP24A1;STMN1;PDGFRB;PIM1;TRP53;APC;ERBB2 |
Prostate cancer | MAPK3;NRAS;PTEN;PIK3CG;SMARCD1;RELA;HSP90AA1;INS2;AKT1 |
Small cell lung cancer | RARB;ITGA6;PIK3CG;IKBKB;PIK3R5;PIK3CB;TP53;ITGA2B;BIRC8 |
CCNE2 has several biochemical functions, for example, cyclin-dependent protein serine/threonine kinase regulator activity, protein binding, protein kinase binding. Some of the functions are cooperated with other proteins, some of the functions could acted by CCNE2 itself. We selected most functions CCNE2 had, and list some proteins which have the same functions with CCNE2. You can find most of the proteins on our site.
Function | Related Protein |
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cyclin-dependent protein serine/threonine kinase regulator activity | CCNL1;CCNK;CCND1;CCNE2;PSTPIP2;CCNT2;CCNC;CCNE1;CCNY |
protein binding | BIN1;CLIP4;SBNO2;KIF1B;UQCC2;STOML2;ZNHIT1;GAN;CCDC9 |
protein kinase binding | FGR;PLK1S1;CDK5R1;YWHAZ;DUSP3;MAML1;TRAF6;ELAVL1;FER |
CCNE2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CCNE2 here. Most of them are supplied by our site. Hope this information will be useful for your research of CCNE2.
CDK2; CDKN1A; CDKN1B; RBL2; ORC3; E7; CDKN1C; CDK3
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