Recombinant Human CCNE2 protein, GST-tagged

• Cat.No.: CCNE2-180H
• Product Overview: Recombinant Human CCNE2 fused with GST tag at N-terminal was expressed in Insect cells.

Specification

• Description: CCNE2 is belongs to the cyclin family, Cyclin E subfamily. It is encoded by a separate gene from Cyclin E1, but shows substantial amino acid sequence similarity. Like Cyclin E1, it binds and activates the cyclin-dependent kinase 2 (Cdk2), which in turn phosphorylates proteins involved in cell cycle progression such as pRB, p107, NPM1, MCMs, thereby driving cell proliferation. A defect in spermatogenesis is the only phenotype observed in cyclin E2-deficient mice, suggesting its role in male fertility.
• Source: Insect cells
• Species: Human
• Tag: GST
• Form: 50mM Tris-HCl, pH 7.5, 150mM NaCl, 10mM glutathione, 0.1mM EDTA, 0.25mM DTT, 0.1mM PMSF, 25% glycerol.
• Molecular Mass: 72 kDa
• Purity: >70%
• Applications: Western Blot
• Stability: 1 year at -70 centigrade from the date of shipment.
• Storage: Store product at –70 centigrade. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
• Concentration: 0.05μg/μl

Gene Information

• Gene Name: CCNE2 cyclin E2 [ Homo sapiens ]
• Official Symbol: CCNE2
• Synonyms: CCNE2; cyclin E2; G1/S-specific cyclin-E2; CYCE2
• Gene ID: 9134
• mRNA Refseq: NM_057749
• Protein Refseq: NP_477097
• MIM: 603775
• UniProt ID: O96020
• Chromosome Location: 8q22.1
• Pathway: Cell Cycle, organism-specific biosystem; Cell Cycle Checkpoints, organism-specific biosystem; Cell Cycle, Mitotic, organism-specific biosystem; Cell cycle, organism-specific biosystem; Cell cycle, organism-specific biosystem; Cell cycle, conserved biosystem; Cyclin A:Cdk2-associated events at S phase entry, organism-specific biosystem
• Function: protein binding; protein kinase binding